Entropy in scalp EEG can be used as a preimplantation marker for VNS efficacy
Language English Country Great Britain, England Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
37914788
PubMed Central
PMC10620210
DOI
10.1038/s41598-023-46113-z
PII: 10.1038/s41598-023-46113-z
Knihovny.cz E-resources
- MeSH
- Electroencephalography MeSH
- Entropy MeSH
- Hyperventilation MeSH
- Humans MeSH
- Vagus Nerve MeSH
- Drug Resistant Epilepsy * therapy MeSH
- Scalp MeSH
- Vagus Nerve Stimulation * methods MeSH
- Treatment Outcome MeSH
- Seizures MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Vagus nerve stimulation (VNS) is a therapeutic option in drug-resistant epilepsy. VNS leads to ≥ 50% seizure reduction in 50 to 60% of patients, termed "responders". The remaining 40 to 50% of patients, "non-responders", exhibit seizure reduction < 50%. Our work aims to differentiate between these two patient groups in preimplantation EEG analysis by employing several Entropy methods. We identified 59 drug-resistant epilepsy patients treated with VNS. We established their response to VNS in terms of responders and non-responders. A preimplantation EEG with eyes open/closed, photic stimulation, and hyperventilation was found for each patient. The EEG was segmented into eight time intervals within four standard frequency bands. In all, 32 EEG segments were obtained. Seven Entropy methods were calculated for all segments. Subsequently, VNS responders and non-responders were compared using individual Entropy methods. VNS responders and non-responders differed significantly in all Entropy methods except Approximate Entropy. Spectral Entropy revealed the highest number of EEG segments differentiating between responders and non-responders. The most useful frequency band distinguishing responders and non-responders was the alpha frequency, and the most helpful time interval was hyperventilation and rest 4 (the end of EEG recording).
Department of Health Sciences Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Scientific Instruments Czech Academy of Sciences Brno Czech Republic
International Clinical Research Center St Anne's University Hospital Brno Czech Republic
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