Transcatheter aortic valve durability, predictors of bioprosthetic valve dysfunction, longer-term outcomes - a review
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review
- Keywords
- Aortic stenosis, bioprosthetic valve dysfunction, calcification, durability, predictors, prevention, structural valve deterioration, transcatheter aortic valve implantation,
- MeSH
- Aortic Valve surgery MeSH
- Aortic Valve Stenosis * surgery MeSH
- Bioprosthesis * MeSH
- Humans MeSH
- Prosthesis Failure MeSH
- Heart Valve Prosthesis * MeSH
- Transcatheter Aortic Valve Replacement * adverse effects methods MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) is one of the most significant inventions in cardiology, as it provides a viable minimally invasive treatment option for patients with aortic stenosis, the most common valvular disease in the developed world and one with a poor prognosis when left untreated. Using data available to date, this review aims to discuss and identify possible predictors of TAVI valve durability - an essential requirement for the device's wide-spread use, especially in younger patients. AREAS COVERED: This article explores the main causes of bioprosthetic valve dysfunction (BVD) based on pathophysiology and available data, and reviews possible predictors of BVD including prosthesis-related, procedure-related, and patient-related factors. An emphasis is made on affectable predictors, which could potentially be targeted with prevention management and improve valve durability. A literature search of online medical databases was conducted using relevant key words and dates; significant clinical trials were identified. A brief overview of important randomized controlled trials with mid to long-term follow-up is included in this article. EXPERT OPINION: Identifying modifiable predictors of valve dysfunction presents an opportunity to enhance and predict valve durability - a necessity as patients with longer life-expectancies are being considered for the procedure.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Cardiology University Hospital Kralovské Vinohrady Prague Czech Republic
References provided by Crossref.org
