Ready-to-use therapeutic/supplementary foods from local food resources: Technology accessibility, program effectiveness, and sustainability, a review

. 2023 Dec ; 9 (12) : e22478. [epub] 20231119

Status PubMed-not-MEDLINE Jazyk angličtina Země Velká Británie, Anglie Médium electronic-ecollection

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid38046154
Odkazy

PubMed 38046154
PubMed Central PMC10686882
DOI 10.1016/j.heliyon.2023.e22478
PII: S2405-8440(23)09686-X
Knihovny.cz E-zdroje

Ready-to-Use Therapeutic Food (RUTF) or Ready-to-Use Supplementary Food (RUSF) has been widely used in home-based treatment for severely and moderately acute malnourished children. These programs showed positive results in short term nutritional recovery in children, which were reported in some research settings. Nowadays, the RUTF/RUSF formulation has been improved using a variety of RUTF/RUSF from locally available food ingredients. This paper aims to review the essential aspects of the development and provision of RUTF/RUSF made from local food resources and monitor program effectiveness that warrants the program's sustainability. The modified recipes of RUTF/RUSF were developed following the international dietary guidelines for the rehabilitation of severely and moderately acute malnourished children. The local production of RUTF/RUSF provided some benefits that include empowering the local community, consideration of the common eating pattern, promoting the diversification of food consumption, strengthening food security, as well as supporting the sustainability of RUTF/RUSF production. Results of the PRISMA-based systematic literature review revealed various ingredient developments and processing techniques which could improve the product characteristics and sensory evaluation. RUTF/RUSF in local food production provided different food carriers (e.g., biscuits, wafers) and seemed to be more readily accepted by the children. Furthermore, the program sustainability of RUTF/RUSF depends on a continuous ingredients supply and support from the local government. The findings presented the importance of development of such food supplements based on the local food resources and with improved technology for prevention and rehabilitation of malnourished children.

Zobrazit více v PubMed

World Health Organization . World Health Organization; 1999. Management of Severe Malnutrition: a Manual for Physicians and Other Senior Health Workers.

Briend A., Lacsala R., Prudhon C., Mounier B., Grellety Y., Golden M.H. Ready-to-use therapeutic food for treatment of marasmus. Lancet. 1999;353(9166):1767–1768. PubMed

Briend A. Highly nutrient-dense spreads: a new approach to delivering multiple micronutrients to high-risk groups. Br. J. Nutr. 2001;85(S2):S175–S179. PubMed

Collins S., Dent N., Binns P., Bahwere P., Sadler K., Hallam A. Management of severe acute malnutrition in children. Lancet. 2006;368(9551):1992–2000. PubMed

Wold Health Organization . World Health Organization; Geneva, Switzerland: 2013. Guideline: Updates on the Management of Severe Acute Malnutrition in Infants and Children.https://www.who.int/publications/i/item/9789241506328 [cited 2023 Aug 15] p. 115. Available from: PubMed

World Food Programme (WFP) World Food Programme; Rome, Italy: 2012. Nutrition at the World Food Programme. Programming for Nutrition-specific Interventions.https://documents.wfp.org/stellent/groups/public/documents/communications/wfp258650.pdf [cited 2023 Aug 15] p. 38. Available from:

Diop E.H.I., Dossou N.I., Ndour M.M., Briend A., Wade S. Comparison of the efficacy of a solid ready-to-use food and a liquid, milk-based diet for the rehabilitation of severely malnourished children: a randomized trial. Am. J. Clin. Nutr. 2003;78(2):302–307. PubMed

Manary M.J., Ndkeha M.J., Ashorn P., Maleta K., Briend A. Home based therapy for severe malnutrition with ready-to-use food. Arch. Dis. Child. 2004 Jun 1;89(6):557–561. PubMed PMC

WHO/WFP/UNSSCN/UNICEF . World Health Organization; 2007. Community-Based Management of Severe Acute Malnutrition : a Joint Statement by the World Health Organization, the World Food Programme, the United Nations System Standing Committee on Nutrition and the United Nations Children’s Fund [Internet]https://apps.who.int/iris/handle/10665/44295 [cited 2021 Sep 25] p. 7. Available from:

Ciliberto M.A., Sandige H., Ndekha M.J., Ashorn P., Briend A., Ciliberto H.M., et al. Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial. Am. J. Clin. Nutr. 2005;81(4):864–870. PubMed

Patel M.P., Sandige H.L., Ndekha M.J., Briend A., Ashorn P., Manary M.J. Supplemental feeding with ready-to-use therapeutic food in Malawian children at risk of malnutrition. J. Health Popul. Nutr. 2005;23(4):351–357. PubMed

Ciliberto M.A., Manary M.J., Ndekha M.J., Briend A., Ashorn P. Home-based therapy for oedematous malnutrition with ready-to-use therapeutic food. Acta Paediatr. 2006;95(8):1012–1015. PubMed

Isanaka S., Roederer T., Djibo A., Luquero F.J., Nombela N., Guerin P.J., et al. Reducing wasting in young children with preventive supplementation: a cohort study in Niger. Pediatrics. 2010 Aug 1;126(2):e442–e450. PubMed PMC

Golden M.H. Proposed recommended nutrient densities for moderately malnourished children. Food Nutr. Bull. 2009 Sep 1;30(3_suppl3):S267–S342. PubMed

Sandige H., Ndekha M.J., Briend A., Ashorn P., Manary M.J. Home-based treatment of malnourished Malawian children with locally produced or imported ready-to-use food. J. Pediatr. Gastroenterol. Nutr. 2004 Aug;39(2):141–146. PubMed

Scherbaum V., Srour M.L. Milk products in the dietary management of childhood undernutrition – a historical review. Nutr. Res. Rev. 2018 Jun;31(1):71–84. PubMed

Brenna J.T., Akomo P., Bahwere P., Berkley J.A., Calder P.C., Jones K.D., et al. Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) BMC Med. 2015 Dec;13(1):117. PubMed PMC

Briend A., Akomo P., Bahwere P., de Pee S., Dibari F., Golden M.H., et al. Developing food supplements for moderately malnourished children: lessons learned from ready-to-use therapeutic foods. Food Nutr. Bull. 2015;36(1S):S53–S58. PubMed

The Sphere Project. Humanitarian Charter and Minimum Standards in Disaster Response [Internet] The Sphere Project; Geneva, Switzerland: 2004. https://www.ifrc.org/docs/idrl/I283EN.pdf [cited 2021 Sep 30] p. 344. Available from: PubMed

Scherbaum V., Purwestri R.C., Stuetz W., MPhil D.A.I., Suryantan J., Bloem M.A., et al. Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? Asia Pac. J. Clin. Nutr. 2015;24(1):152–161. PubMed

Manary M., Callaghan M., Singh L., Briend A. Protein quality and growth in malnourished children. Food Nutr. Bull. 2016;37(1_suppl):S29–S36. PubMed

Liberati A., Altman D.G., Tetzlaff J., Mulrow C., Gøtzsche P.C., Ioannidis J.P.A., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009 Jul 21;6(7) PubMed PMC

Linneman Z., Matilsky D., Ndekha M., Manary M.J., Maleta K., Manary M.J. A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi. Matern. Child Nutr. 2007 Jul;3(3):206–215. PubMed PMC

Purwestri R.C., Scherbaum V., Wirawan N.N., Suryantan J., Bloem M.A., Pangaribuan R.V., et al. Supplementary feeding with locally-produced Ready-to- Use Food (RUF) for mildly wasted children on Nias Island, Indonesia: comparison of daily and weekly program outcomes. Asia Pac. J. Clin. Nutr. 2012;21(3):374–379. PubMed

Fetriyuna F., Purwestri R.C., Susandy M., Köhler R., Jati I.R.A.P., Wirawan N.N., et al. Composite flour from Indonesian local food resources to develop cereal/tuber nut/bean-based ready-to-use supplementary foods for prevention and rehabilitation of moderate acute malnutrition in children. Foods. 2021 Dec 5;10(12):3013. PubMed PMC

Owino V.O., Irena A.H., Dibari F., Collins S. Development and acceptability of a novel milk‐free soybean–maize–sorghum ready‐to‐use therapeutic food (SMS‐RUTF) based on industrial extrusion cooking process. Matern. Child Nutr. 2012;10(1):126–134. PubMed PMC

Bahwere P., Balaluka B., Wells J.C., Mbiribindi C.N., Sadler K., Akomo P., et al. Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste–based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial. Am. J. Clin. Nutr. 2016 Apr 1;103(4):1145–1161. PubMed

Ahmed T., Choudhury N., Hossain M.I., Tangsuphoom N., Islam M.M., de Pee S., et al. Development and acceptability testing of ready-to-use supplementary food made from locally available food ingredients in Bangladesh. BMC Pediatr. 2014 Dec;14(1):164. PubMed PMC

Choudhury N., Ahmed T., Hossain M.I., Islam M.M., Sarker S.A., Zeilani M., et al. Ready-to-Use therapeutic food made from locally available food ingredients is well accepted by children having severe acute malnutrition in Bangladesh. Food Nutr. Bull. 2018 Mar;39(1):116–126. PubMed

Hsieh J.C., Liu L., Zeilani M., Ickes S., Trehan I., Maleta K., et al. High-oleic ready-to-use therapeutic food maintains docosahexaenoic acid status in severe malnutrition. J. Pediatr. Gastroenterol. Nutr. 2015 Jul;61(1):138–143. PubMed PMC

Stobaugh H.C., Ryan K.N., Kennedy J.A., Grise J.B., Crocker A.H., Thakwalakwa C., et al. Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial. Am. J. Clin. Nutr. 2016 Mar 1;103(3):926–933. PubMed

Weber J.M., Ryan K.N., Tandon R., Mathur M., Girma T., Steiner-Asiedu M., et al. Acceptability of locally produced ready-to-use therapeutic foods in Ethiopia, Ghana, Pakistan and India: acceptability of local RUTF. Matern. Child Nutr. 2017 Apr;13(2) PubMed PMC

Nga T.T., Nguyen M., Mathisen R., Hoa D.T., Minh N.H., Berger J., et al. Acceptability and impact on anthropometry of a locally developed Ready-to-use therapeutic food in pre-school children in Vietnam. Nutr. J. 2013 Dec;12(1):120. PubMed PMC

Borg B., Mihrshahi S., Griffin M., Chamnan C., Laillou A., Wieringa F.T. Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol. BMJ Open. 2017 Sep;7(9) PubMed PMC

Borg B., Mihrshahi S., Griffin M., Sok D., Chhoun C., Laillou A., et al. Randomised controlled trial to test the effectiveness of a locally-produced ready-to-use supplementary food (RUSF) in preventing growth faltering and improving micronutrient status for children under two years in Cambodia: a study protocol. Nutr. J. 2018 Dec;17(1):39. PubMed PMC

Borg B., Mihrshahi S., Griffin M., Sok D., Chhoun C., Laillou A., et al. Acceptability of locally‐produced Ready‐to‐Use Supplementary Food (RUSF) for children under two years in Cambodia: a cluster randomised trial. Matern. Child Nutr. 2019 Jul;15(3) PubMed PMC

Sigh S., Roos N., Sok D., Borg B., Chamnan C., Laillou A., et al. Development and acceptability of locally made fish-based, ready-to-use products for the prevention and treatment of malnutrition in Cambodia. Food Nutr. Bull. 2018 Sep;39(3):420–434. PubMed

Sigh S., Roos N., Chamnan C., Laillou A., Prak S., Wieringa F. Effectiveness of a locally produced, fish-based food product on weight gain among Cambodian children in the treatment of acute malnutrition: a randomized controlled trial. Nutrients. 2018 Jul 16;10(7):909. PubMed PMC

Armini V., Miele N.A., Albero M., Sacchi R., Cavella S. Formula optimization approach for an alternative ready-to-use therapeutic food. Food Sci. Technol. 2018;6

Miele N.A., Armini V., Troccoli A.M., Puleo S., Paduano A., Sacchi R., et al. Sensory evaluation and volatile compounds of an alternative ready‐to‐use therapeutic food for malnourished children. J. Food Sci. 2020 Apr;85(4):1265–1273. PubMed

Azimi F. Effect of a newly developed ready-to-use supplementary food on growth indicators in children with mild to moderate malnutrition. Publ. Health. 2020;8 PubMed

Hossain MdI., Huq S., Islam M.M., Ahmed T. Acceptability and efficacy of ready-to-use therapeutic food using soy protein isolate in under-5 children suffering from severe acute malnutrition in Bangladesh: a double-blind randomized non-inferiority trial. Eur. J. Nutr. 2020 Apr;59(3):1149–1161. PubMed

Javed F., Jabeen S., Sharif M.K., Riaz A., Manzoor M.F., Sahar A., et al. Development and storage stability of chickpea, mung bean, and peanut‐based ready‐to‐use therapeutic food to tackle protein‐energy malnutrition. Food Sci. Nutr. 2021 Jul 19 fsn3.2479. PubMed PMC

Manary M.J. Local production and provision of ready-to-use therapeutic food (rutf) spread for the treatment of severe childhood malnutrition. Food Nutr. Bull. 2006 Sep;27(3_suppl3):S83–S89. PubMed

Sato W., Furuta C., Matsunaga K., Bahwere P., Collins S., Sadler K., et al. Amino-acid-enriched cereals ready-to-use therapeutic foods (RUTF) are as effective as milk-based RUTF in recovering essential amino acid during the treatment of severe acute malnutrition in children: an individually randomized control trial in Malawi. van Wouwe JP. PLoS One. 2018 Aug 10;13(8) PubMed PMC

Sato W., Furuta C., Akomo P., Bahwere P., Collins S., Sadler K., et al. Amino acid-enriched plant-based RUTF treatment was not inferior to peanut-milk RUTF treatment in restoring plasma amino acid levels among patients with oedematous or non-oedematous malnutrition. Sci. Rep. 2021 Dec;11(1) PubMed PMC

Chalupa-Krebzdak S., Long C.J., Bohrer B.M. Nutrient density and nutritional value of milk and plant-based milk alternatives. Int. Dairy J. 2018 Dec;87:84–92.

Tenyang N., Ponka R., Tiencheu B., Djikeng F.T., Womeni H.M. Effect of traditional drying methods on proximate composition, fatty acid profile, and oil oxidation of fish species consumed in the far‐north of Cameroon. Glob. Chall. 2020 Aug;4(8) PubMed PMC

Agume A., Njintang N., Mbofung C. Effect of soaking and roasting on the physicochemical and pasting properties of soybean flour. Foods. 2017 Feb 10;6(2):12. PubMed PMC

Cummings J.H., Stephen A.M. Carbohydrate terminology and classification. Eur. J. Clin. Nutr. 2007 Dec;61(S1):S5–S18. PubMed

Bandsma R.H.J., Voskuijl W., Chimwezi E., Fegan G., Briend A., Thitiri J., et al. A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: a double-blind, randomized controlled trial. Persson LÅ. PLoS Med. 2019 Feb 26;16(2) PubMed PMC

Iddrisu I., Monteagudo-Mera A., Poveda C., Pyle S., Shahzad M., Andrews S., et al. Malnutrition and gut microbiota in children. Nutrients. 2021 Aug 8;13(8):2727. PubMed PMC

Gillison F., Grey E., Verplanken B., Barnett J., Baber F. Food Standards Agency; 2022. A Rapid Review of the Acceptability and Impact of Approaches to Reduce the Salt, Fat and Sugar Content of People’s Diets on Consumers and Industry.https://www.food.gov.uk/research/behaviour-and-perception/a-rapid-review-of-the-acceptability-and-impact-of-approaches-to-reduce-the-salt-fat-and-sugar-content-of-peoples-diets-on Mar [cited 2022 Jun 29]. Available from:

Ashwath Kumar K., Sudha M.L. Effect of fat and sugar replacement on rheological, textural and nutritional characteristics of multigrain cookies. J. Food Sci. Technol. 2021 Jul;58(7):2630–2640. PubMed PMC

Shang Y., Cao H., Wei C., Thakur K., Liao A., Huang J., et al. Effect of sugar types on structural and flavor properties of peony seed derived Maillard reaction products. J. Food Process. Preserv. 2020 Mar;44(3)

Bobade H., Singh A., Sharma S., Gupta A., Singh B. Effect of extrusion conditions and honey on functionality and bioactive composition of whole wheat flour‐based expanded snacks. Food Process. Preserv. 2022 Jan;46(1)

Bousi C., Sismanidou O.X., Marinopoulou A., Raphaelides S. Effect of sugar addition on the elongational and shearing deformation behavior of sesame paste systems. LWT. 2022 Jan;153

Bertelsen A.S., Mielby L.A., Byrne D.V., Kidmose U. Ternary cross-modal interactions between sweetness, aroma, and viscosity in different beverage matrices. Foods. 2020 Mar 30;9(4):395. PubMed PMC

Forouhi N.G., Krauss R.M., Taubes G., Willett W. Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance. BMJ. 2018 Jun 13 PubMed PMC

Das J.K., Hoodbhoy Z., Salam R.A., Bhutta A.Z., Valenzuela-Rubio N.G., Weise Prinzo Z., et al. Cochrane Developmental, Psychosocial and Learning Problems Group. Cochrane Database of Systematic Reviews; 2018 Aug 31. Lipid-based nutrient supplements for maternal, birth, and infant developmental outcomes. [cited 2022 Jun 29];2018(8). Available from. PubMed PMC

Huybregts L., Le Port A., Becquey E., Zongrone A., Barba F.M., Rawat R., et al. Impact on child acute malnutrition of integrating small-quantity lipid-based nutrient supplements into community-level screening for acute malnutrition: a cluster-randomized controlled trial in Mali. Persson LÅ, editor. PLoS Med. 2019 Aug 27;16(8) PubMed PMC

Smit E.N., Muskiet F.A.J., Boersma E.R. The possible role of essential fatty acids in the pathophysiology of malnutrition: a review. Prostagl. Leukot. Essent. Fat. Acids. 2004 Oct;71(4):241–250. PubMed

Zuzarte A., Mui M., Ordiz M.I., Weber J., Ryan K., Manary M.J. Reducing oil separation in ready-to-use therapeutic food. Foods. 2020 Jun 1;9(6):706. PubMed PMC

Tzompa-Sosa D.A., Dewettinck K., Gellynck X., Schouteten J.J. Replacing vegetable oil by insect oil in food products: effect of deodorization on the sensory evaluation. Food Res. Int. 2021 Mar;141 PubMed

Gutiérrez-Luna K., Astiasarán I., Ansorena D. Gels as fat replacers in bakery products: a review. Crit. Rev. Food Sci. Nutr. 2022 Aug 6;62(14):3768–3781. PubMed

Evlogimenou A., Paraskevopoulou A., Kiosseoglou V. Exploitation of hazelnut, maize germ and sesame seed aqueous extraction residues in the stabilisation of sesame seed paste (tahini): physical stabilisation of sesame seed paste. J. Sci. Food Agric. 2017 Jan;97(1):215–221. PubMed

Kong X., Li X., Wang H., Hua Y., Huang Y. Effect of lipoxygenase activity in defatted soybean flour on the gelling properties of soybean protein isolate. Food Chem. 2008 Feb;106(3):1093–1099.

Speroni F., Milesi V., Añón M.C. Interactions between isoflavones and soybean proteins: applications in soybean-protein–isolate production. LWT - Food Sci. Technol. (Lebensmittel-Wissenschaft -Technol.) 2010 Oct;43(8):1265–1270.

Triyono A. Semarang, Indonesia. Universitas Diponegoro; 2010. Mempelajari pengaruh penambahan beberapa asam pada proses isolasi protein terhadap tepung protein isolat kacang Hijau (phaseolus radiatus L.) pp. 4–5.http://eprints.undip.ac.id/27996/1/C-10.pdf Available from:

Camargo L. da R., Doneda D., Oliveira V.R. Whey protein ingestion in elderly diet and the association with physical, performance and clinical outcomes. Exp. Gerontol. 2020 Aug;137 PubMed

Alimoradi F., Hojaji E., Jooyandeh H., Moghadam S.A.H.Z., Moludi J. Whey protein : health benefit and food applications whey protein. J. Int. Res. Med. Pharmaceut. Sci. 2016;9(2):63–73.

Andoyo R., Dianti Lestari V., Mardawati E., Nurhadi B. Fractal dimension analysis of texture formation of whey protein-based foods. Int. J. Food Sci. 2018;2018:17. PubMed PMC

Weindl I., Ost M., Wiedmer P., Schreiner M., Neugart S., Klopsch R., et al. Sustainable food protein supply reconciling human and ecosystem health: a Leibniz Position. Global Food Secur. 2020 Jun;25

Kabir I., Rahman M.M., Haider R., Mazumder R.N., Khaled M.A., Mahalanabis D. Increased height gain of children fed a high-protein diet during convalescence from shigellosis: a six-month follow-up study. J. Nutr. 1998 Oct 1;128(10):1688–1691. PubMed

Khairunnisa S., Andoyo R., Marta H., Saripudin G.L.U. Process optimization of emergency food originated from denatured whey protein concentrate and dried sweet potato puree. IOP Conf. Ser. Earth Environ. Sci. 2018 May;157

Andoyo R., Mahani M., Ain M.N., Wira D.W., Wilar G., Darwis R.S., et al. Pre-clinical study of the high protein food based on denaturized whey protein. Sys. Rev. Pharm. 2021;12(1):759–770.

Prabhakar K. Encyclopedia of Food Microbiology. Elsevier; 2014. Intermediate moisture foods.https://linkinghub.elsevier.com/retrieve/pii/B9780123847300001701 [cited 2022 Jun 29]. pp. 372–6. Available from:

Shenoy P., Viau M., Tammel K., Innings F., Fitzpatrick J., Ahrné L. Effect of powder densities, particle size and shape on mixture quality of binary food powder mixtures. Powder Technol. 2015 Mar;272:165–172.

Belorio M., Sahagún M., Gómez M. Influence of flour particle size distribution on the quality of maize gluten-free cookies. Foods. 2019 Feb 23;8(2):83. PubMed PMC

Bahwere P., Akomo P., Mwale M., Murakami H., Banda C., Kathumba S., et al. Soya, maize, and sorghum–based ready-to-use therapeutic food with amino acid is as efficacious as the standard milk and peanut paste–based formulation for the treatment of severe acute malnutrition in children: a noninferiority individually randomized controlled efficacy clinical trial in Malawi. Am. J. Clin. Nutr. 2017 Oct;106(4):1100–1112. PubMed

Akomo P., Bahwere P., Murakami H., Banda C., Maganga E., Kathumba S., et al. Soya, maize and sorghum ready-to-use therapeutic foods are more effective in correcting anaemia and iron deficiency than the standard ready-to-use therapeutic food: randomized controlled trial. BMC Publ. Health. 2019 Dec;19(1):806. PubMed PMC

Wagh V.D. Ready to use therapeutic food [RUTF] formulation and packaging for malnutrition. Nutr. Food Sci. Int. J. 2017;4(5)

Barrett J.R. National Institute of Environmental Health Sciences; 2005. Liver Cancer and Aflatoxin: New Information from the Kenyan Outbreak.

Wagh V.D., Deore B.R. Ready to use therapeutic food (RUTF): an overview. Adv. Life Sci. Health. 2015;2(1):15–30.

Centers for Disease Control and Prevention (CDC) Outbreak of aflatoxin poisoning--eastern and central provinces, Kenya, January-July 2004. MMWR Morb. Mortal. Weekly Rep. 2004 Sep 3;53(34):790–793. PubMed

Gong Y., Hounsa A., Egal S., Turner P.C., Sutcliffe A.E., Hall A.J., et al. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ. Health Perspect. 2004 Sep;112(13):1334–1338. PubMed PMC

Patterson G.T., Osorio E.Y., Peniche A., Dann S.M., Cordova E., Preidis G.A., et al. Pathologic inflammation in malnutrition is driven by proinflammatory intestinal microbiota, large intestine barrier dysfunction, and translocation of bacterial lipopolysaccharide. Front. Immunol. 2022 May 26;13 PubMed PMC

Hashimoto T., Perlot T., Rehman A., Trichereau J., Ishiguro H., Paolino M., et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 2012 Jul;487(7408):477–481. PubMed PMC

Tidjani Alou M., Lagier J.C., Raoult D. Diet influence on the gut microbiota and dysbiosis related to nutritional disorders. Human Microb. J. 2016 Sep;1:3–11.

Benjamin J., Makharia G., Ahuja V., Anand Rajan K.D., Kalaivani M., Gupta S.D., et al. Glutamine and whey protein improve intestinal permeability and morphology in patients with crohn’s disease: a randomized controlled trial. Dig. Dis. Sci. 2012 Apr;57(4):1000–1012. PubMed

Prokopidis K., Mazidi M., Sankaranarayanan R., Tajik B., McArdle A., Isanejad M. Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis. Br. J. Nutr. 2022 Jun 16:1–12. PubMed PMC

Ma N., Tian Y., Wu Y., Ma X. CPPS; 2017 Jun 2. Contributions of the Interaction between Dietary Protein and Gut Microbiota to Intestinal Health.http://www.eurekaselect.com/150179/article [cited 2023 Apr 10];18(8). Available from: PubMed

Jewell J.L., Russell R.C., Guan K.L. Amino acid signalling upstream of mTOR. Nat. Rev. Mol. Cell Biol. 2013 Mar;14(3):133–139. PubMed PMC

Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell. 2012 Apr;149(2):274–293. PubMed PMC

Biesalski H.K. Springer Science & Business Media; Heidelberg, Germany: 2013 Jan. Hidden Hunger; p. 265.

Hrubša M., Siatka T., Nejmanová I., Vopršalová M., Kujovská Krčmová L., Matoušová K., et al. Biological properties of vitamins of the B-complex, part 1: vitamins B1, B2, B3, and B5. Nutrients. 2022;14(3):484. PubMed PMC

Watzke H.J. Impact of processing on bioavailability examples of minerals in foods. Trends Food Sci. Technol. 1998 Aug;9(8–9):320–327.

de Almeida M.M.C., Francisco C.R.L., de Oliveira A., de Campos S.S., Bilck A.P., Fuchs R.H.B., et al. Textural, color, hygroscopic, lipid oxidation, and sensory properties of cookies containing free and microencapsulated chia oil. Food Bioprocess Technol. 2018 May;11(5):926–939.

Qiu L., Zhang M., Tang J., Adhikari B., Cao P. Innovative technologies for producing and preserving intermediate moisture foods: a review. Food Res. Int. 2019 Feb;116:90–102. PubMed

Gama T., Wallace H.M., Trueman S.J., Hosseini-Bai S. Quality and shelf life of tree nuts: a review. Sci. Hortic. 2018 Dec;242:116–126.

Yazew T. In: Therapeutic Food Development from Maize Grains, Pulses, and Cooking Banana Fruits for the Prevention of Severe Acute Malnutrition. Capurso C., editor. The Scientific World Journal; 2022 Jan 29. pp. 1–7. 2022. PubMed PMC

Hadi S., Amani R., Tehrani M.M., Hadi V., Hejri S., Askari G. Ready-to-Use therapeutic food (RUTF) formulations with functional food and nutrient density for the treatment of malnutrition in crisis. Int. J. Prev. Med. 2022;13:16. PubMed PMC

Adewumi O.O., Felix-Minnaar J.V., Jideani V.A. Physiochemical and nutritional characteristics of ready-to-use therapeutic food prepared using Bambara groundnut-moringa oleifera leaf protein complex. Foods. 2022 Jun 8;11(12):1680. PubMed PMC

Akande O.A., Oluwamukomi M., Osundahunsi O.F., Ijarotimi O.S., Mukisa I.M. Evaluating the potential for utilising migratory locust powder (Locusta migratoria) as an alternative protein source in peanut-based ready-to-use therapeutic foods. Food Sci. Technol. Int. 2023 Apr;29(3):204–216. PubMed

Bahwere P., Banda T., Sadler K., Nyirenda G., Owino V., Shaba B., et al. Effectiveness of milk whey protein‐based ready‐to‐use therapeutic food in treatment of severe acute malnutrition in M alawian under‐5 children: a randomised, double‐blind, controlled non‐inferiority clinical trial. Matern. Child Nutr. 2014 Jul;10(3):436–451. PubMed PMC

Fetriyuna F., Purwestri R.C., Susandy M., Köhler R., Jati I.R.A.P., Wirawan N.N., et al. Composite flour from Indonesian local food resources to develop cereal/tuber nut/bean-based ready-to-use supple-mentary foods for prevention and rehabilitation of mod-erate acute malnutrition in children. Foods. 2021 (not yet published) PubMed PMC

Dibari F., Bahwere P., Huerga H., Irena A.H., Owino V., Collins S., et al. Development of a cross-over randomized trial method to determine the acceptability and safety of novel ready-to-use therapeutic foods. Nutrition. 2013 Jan;29(1):107–112. PubMed

Borg B., Mihrshahi S., Laillou A., Sigh S., Sok D., Peters R., et al. Development and testing of locally-produced ready-to-use therapeutic and supplementary foods (RUTFs and RUSFs) in Cambodia: lessons learned. BMC Publ. Health. 2019;19(1):1–9. PubMed PMC

Kshirsagar R., Bach M., Forteza M.E. 2019. Expert Meeting on Ready-To-Use-Therapeutic Foods (RUTF) UNICEF, Supply Division | Report 1 | 2nd-3rd September.https://www.unicef.org/supply/media/3316/file/RUTF-technical-expert-meeting-report-02-03092019.pdf.pdf [Internet]. 2019 [cited 2021 Sep 10] p. 21. Available from:

Purwestri R.C., Scherbaum V., Inayati D.A., Wirawan N.N., Suryantan J., Bloem M.A., et al. Impact of daily versus weekly supply of locally produced ready-to-use food on growth of moderately wasted children on nias island, Indonesia. ISRN Nutr. 2013:1–10. 2013 Feb 27. PubMed PMC

Maleta K., Kuittinen J., Duggan M.B., Briend A., Manary M., Wales J., et al. Supplementary feeding of underweight, stunted Malawian children with a ready-to-use food. J. Pediatr. Gastroenterol. Nutr. 2004 Feb;38(2):152–158. PubMed

Matilsky D.K., Maleta K., Castleman T., Manary M.J. Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children. J. Nutr. 2009;139(4):773–778. PubMed PMC

Irena A.H., Bahwere P., Owino V.O., Diop E.I., Bachmann M.O., Mbwili-Muleya C., et al. Comparison of the effectiveness of a milk-free soy-maize-sorghum-based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non-blin: effectiveness of a soya-maize-sorghum RUTF. Matern. Child Nutr. 2015 Dec;11:105–119. PubMed PMC

Nguyen M., Berger J., Wieringa F., Tran T.N., Do T.B.H., Nguyen H.M., et al. Effectiveness of a locally produced RUTF for the treatment of acute malnutrition in Vietnam. IAEA. 2014 Jul 1;2014

Schoonees A., Lombard M.J., Musekiwa A., Nel E., Volmink J. Ready‐to‐use therapeutic food (RUTF) for home‐based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age. Cochrane Database Syst. Rev. 2019;5 PubMed PMC

Christian P., Shaikh S., Shamim A.A., Mehra S., Wu L., Mitra M., et al. Effect of fortified complementary food supplementation on child growth in rural Bangladesh: a cluster-randomized trial. Int. J. Epidemiol. 2015 Dec;44(6):1862–1876. PubMed PMC

Food and Nutrition Technical Assistance III Project (FANTA). Training Guide for Community-Based Management of Acute Malnutrition (CMAM) FHI 360/FANTA; Washington DC: 2018. https://www.fantaproject.org/focus-areas/nutrition-emergencies-mam/cmam-training 2018 [cited 2021 Oct 10] p. 175. Available from:

Republik Vietnam . Medical Publishing House; 2011. National Nutrition Strategy for 2011-2020, with A Vision toward 2030.https://extranet.who.int/nutrition/gina/sites/default/filesstore/VNM%202011%202.%20National%20Nutrition%20%20Strategy%202011-2020.pdf [cited 2023 Mar 4]. Available from:

FAO . Food and Agriculture Organization; United Nation: 2022. New Codex Alimentarius Guideline Means Ready-To-Use Therapeutic Foods Can Be Manufactured and Incorporated into More Countries’ Health Plans.https://www.fao.org/fao-stories/article/en/c/1619824/ [cited 2022 Mar 4]. Available from:

Phuong H., Nga T.T., Mathisen R., Nguyen M., Hop L.T., Hoa D.T.B., et al. Development and implementation of a locally produced ready-to-use therapeutic food (RUTF) in Vietnam. Food Nutr. Bull. 2014 Jun;35(2_suppl1):S52–S56. PubMed

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