Biological processes involving immune response exhibit nonlinearity due to complex interactions between different cells. The presented mathematical model considers the temporal development of immune reactions, and corresponding kinetic processes, including the interaction of cells/soluble immune factors in vitro. According to the M1/M2 paradigm of macrophage polarization, unbalanced macrophage activation in the human body can cause an excessive response to an antigen and associated long-term deleterious processes. Therefore, our simulation is based on the evaluation of parameters that describe the interaction of diverse immune factors interconnected within the framework of the M1/M2 paradigm, and taking into account the kinetics of expression of immune factors. A specific program and related web tool to assess the intensity of immune reactions in cell system in vitro were developed. AVAILABILITY: It is accessible through a web-link: https://www.biodevicesystems.com/immunology. CONTACT: Users can get information and apply for the service at info@biodevicesystems.com.

BioDevice Systems SME Praha 10 Vršovice Bulharská 996 20 Czech Republic

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