Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future.

Department of Chemistry Faculty of Science Humanities and Education Technical University of Liberec Liberec Czech Republic

Department of Heart Surgery East Slovak Institute of Cardiovascular Diseases Inc Košice Slovak Republic

Department of Orthopaedics University J E Purkině and Masaryk Hospital Ústí nad Labem Czech Republic; Department of Histology and Embryology 2nd Faculty of Medicine Charles University Prague Czech Republic; Department of Orthopaedic Surgery Faculty of Medicine in Hradec Králové Charles University Hradec Králové Czech Republic

Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University Košice Slovak Republic

Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University Košice Slovak Republic; Department of Biomedical Research East Slovak Institute of Cardiovascular Diseases Inc Košice Slovak Republic

Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czech Republic

Laboratory of Biomaterials and Tissue Engineering Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic

Prague Burn Center 3rd Faculty of Medicine Charles University and Královské Vinohrady University Hospital Prague Czech Republic

Prague Burn Center 3rd Faculty of Medicine Charles University and Královské Vinohrady University Hospital Prague Czech Republic; Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University Košice Slovak Republic; Department of Biomedical Research East Slovak Institute of Cardiovascular Diseases Inc Košice Slovak Republic; Department of Pharmacognosy and Botany Faculty of Pharmacy Comenius University Bratislava Slovak Republic; Biomedical Research Center of the Slovak Academy of Sciences Košice Slovak Republic

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