Global imperatives have recently shown a paradigm shift in the prevailing resource utilization model from a linear approach to a circular bioeconomy. The primary goal of the circular bioeconomy model is to minimize waste by effective re-usage of organic waste and efficient nutrient recycling. In essence, circular bioeconomy integrates the fundamental concept of circular economy, which strives to offer sustainable goods and services by leveraging biological resources and processes. Notably, the circular bioeconomy differs from conventional waste recycling by prioritizing the safeguarding and restoration of production ecosystems, focusing on harnessing renewable biological resources and their associated waste streams to produce value-added products like food, animal feed, and bioenergy. Amidst these sustainability efforts, fruit seeds are getting considerable attention, which were previously overlooked and commonly discarded but were known to comprise diverse chemicals with significant industrial applications, not limited to cosmetics and pharmaceutical industries. While, polyphenols in these seeds offer extensive health benefits, the inadequate conversion of fruit waste into valuable products poses substantial environmental challenges and resource wastage. This review aims to comprehend the known information about the application of non-edible fruit seeds for synthesising metallic nanoparticles, carbon dots, biochar, biosorbent, and biodiesel. Further, this review sheds light on the potential use of these seeds as functional foods and feed ingredients; it also comprehends the safety aspects associated with their utilization. Overall, this review aims to provide a roadmap for harnessing the potential of non-edible fruit seeds by adhering to the principles of a sustainable circular bioeconomy.

Amity Institute of Food Technology Amity University Noida 201313 India

Centre of Advanced Technologies Faculty of Science University of Hradec Kralove Rokitanskeho 62 50003 Hradec Kralove Czech Republic

Department of Ayurveda and Health Sciences Abhilashi University Mandi 175028 India

Department of Biotechnology Thapar Institute of Engineering and Technology Patiala 147001 India

Department of Biotechnology TIFAC Centre of Relevance and Excellence in Agro and Industrial Biotechnology Thapar Institute of Engineering and Technology Patiala 147001 India

Department of Chemistry Faculty of Science University of Hradec Kralove 50003 Hradec Kralove Czech Republic; Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic

Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar 143005 India

School of Bioengineering and Biosciences Lovely Professional University Phagwara Punjab 144411 India

School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management Sciences Solan 173229 India

Zoology Department College of Science King Saud University Riyadh 11451 Saudi Arabia

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