Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, a class of naturally occurring compounds, are immensely beneficial for the treatment or management of various disorders and illnesses. Naturally occurring sources of polyphenols include plants and plant-based foods, such as fruits, herbs, tea, vegetables, coffee, red wine, and dark chocolate. Polyphenols have unique properties, such as being the major source of anti-oxidants and possessing anti-aging and anti-cancerous properties. Currently, dietary polyphenols have become a potential therapeutic approach for the management of AD, depending on various research findings. Dietary polyphenols can be an effective strategy to tackle multifactorial events that occur with AD. For instance, naturally occurring polyphenols have been reported to exhibit neuroprotection by modulating the Aβ biogenesis pathway in AD. Many nanoformulations have been established to enhance the bioavailability of polyphenols, with nanonization being the most promising. This review comprehensively provides mechanistic insights into the neuroprotective potential of dietary polyphenols in treating AD. It also reviews the usability of dietary polyphenol as nanoformulation for AD treatment.

Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical Technology Jadavpur University Kolkata 700032 India

Centre for Global Health Research Saveetha Medical College Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India; Centre of Research Impact and Outcome Chitkara University Rajpura 140401 Punjab India ; School of Bioengineering and Biosciences Lovely Professional University Phagwara 144411 India; Department of Biotechnology School of Applied and Life Sciences Uttaranchal University Dehradun India

Department of Animal Morphology Physiology and Genetics Faculty of AgriSciences Mendel University in Brno Brno Czech Republic

Department of Biomedical Sciences College of Health Sciences Abu Dhabi University Abu Dhabi United Arab Emirates

Department of Clinical Laboratory Sciences College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Dammam Eastern Province 34212 Saudi Arabia

Department of Health Information Management College of Applied Medical Sciences Buraydah Private Colleges Buraydah 51418 Saudi Arabia

Department of Medical Laboratory Sciences College of Applied Medical Sciences Majmaah University Al Majmaah 11952 Saudi Arabia

Department of Medical Laboratory Sciences College of Applied Medical Sciences University of Bisha Bisha 61922 Saudi Arabia

Department of Pathology Faculty of Medicine Umm Al Qura University Makkah 21955 Saudi Arabia

Department of Pharmaceutical Chemistry College of Pharmacy Prince Sattam Bin Abdulaziz University Al Kharj 11942 Saudi Arabia

Department of Pharmaceutical Sciences Bengal College of Pharmaceutical Sciences and Research Durgapur 713212 West Bengal India

Department of Pharmaceutical Sciences Maharshi Dayanad University Rohtak Haryana 124001 India

Department of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra Coimbra Portugal; REQUIMTE LAQV Group of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra Coimbra Portugal

Department of Pharmacology and Therapeutics College of Medicine and Health Sciences United Arab Emirates University P O Box 15551 Al Ain United Arab Emirates

Department of Zoology Kalindi College University of Delhi 110008 India

GloNeuro Noida India

Institute of Pharmaceutical Research GLA University Mathura India

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