Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu systematický přehled, časopisecké články, přehledy
Grantová podpora
APVV-20-0447
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
APVV-19-0585
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
MULTI-MEMO
EU Joint Programme - Neurodegenerative Disease Research
2/0127/22
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
873127
HORIZON EUROPE Marie Sklodowska-Curie Actions
PubMed
38576010
PubMed Central
PMC10993623
DOI
10.1186/s40478-024-01748-5
PII: 10.1186/s40478-024-01748-5
Knihovny.cz E-zdroje
- Klíčová slova
- Aggregation, Animal models, Neurofibrillary tangles, Propagation, Spreading, Tau protein,
- MeSH
- Alzheimerova nemoc * patologie MeSH
- modely nemocí na zvířatech MeSH
- mozek patologie MeSH
- neurofibrilární klubka patologie MeSH
- proteiny tau metabolismus MeSH
- tauopatie * patologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- systematický přehled MeSH
- Názvy látek
- proteiny tau MeSH
The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
AXON Neuroscience R and D Services SE Dubravska Cesta 9 845 10 Bratislava Slovakia
Biomedical Research Institute BIOMED Hasselt University 3500 Hasselt Belgium
CEITEC Masaryk University Kamenice 5 625 00 Brno Czech Republic
CNRS EMR9002 BSI Integrative Structural Biology 59000 Lille France
Department of Chemistry Faculty of Science Masaryk University Kamenice 5 62500 Brno Czech Republic
Einstein Center for Neurosciences Berlin Charité Universitätsmedizin Berlin Berlin Germany
German Center for Neurodegenerative Diseases Charitéplatz 1 10117 Berlin Germany
Institute of Neuroimmunology Slovak Academy of Sciences Dubravska Cesta 9 845 10 Bratislava Slovakia
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