Metabolically healthy obesity and health risks - a review of meta-analyses
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
38669161
DOI
10.21101/cejph.a7806
Knihovny.cz E-zdroje
- Klíčová slova
- body fat percentage, fit and fat phenomenon, meta-analysis, metabolically healthy obesity, pathogenesis of obesity, visceral fat,
- MeSH
- diabetes mellitus 2. typu epidemiologie MeSH
- kardiovaskulární nemoci epidemiologie etiologie MeSH
- lidé MeSH
- metaanalýza jako téma MeSH
- metabolicky zdravá obezita * MeSH
- obezita epidemiologie MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
OBJECTIVE: This article briefly summarizes the results of existing research on metabolically healthy obesity in the context of health risks. METHODS: The PubMed database was searched for relevant meta-analyses addressing metabolically healthy obesity in the context of health risks. RESULTS: We included a total of 17 relevant meta-analyses in this review. The results of the studied meta-analyses showed that metabolically healthy obesity may be only a transient condition associated with an increased risk of developing metabolic abnormalities in the future. People with obesity without metabolic abnormalities have an increased risk of type 2 diabetes, cardiovascular disease, cancer, chronic kidney disease, and depressive syndrome. In addition, all people with obesity are at risk of pathogenesis resulting from the mechanical stress caused by presence of abnormal adipose tissue, such as sleep apnoea syndrome or skin problems. CONCLUSION: Based on the results of meta-analyses, we recommend motivating all obese patients to change their lifestyle regardless of the presence of metabolic defects.
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World Health Organization. Obesity and overweight [Internet]. Geneva: WHO; 2023 [cited 2022 Sep 30]. Available from: https://www.who.int/health-topics/obesity.
Oliveros E, Somers VK, Sochor O, Goel K, Lopez-Jimenez F. The Concept of normal weight obesity. Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):426-33. PubMed DOI
World Health Organization. Waist circumference and waist-hip ratio: report of a WHO expert consultation, Geneva, 8-11 December 2008 [Internet]. Geneva: WHO; 2011 [cited 2022 Oct 13]. Available from: https://apps.who.int/iris/bitstream/handle/10665/44583/?sequence=1.
Blüher M. Metabolically healthy obesity. Endocr Rev. 2020 May 1;41(3):bnaa004. doi: 10.1210/endrev/bnaa004. PubMed DOI
Smith GI, Mittendorfer B, Klein S. Metabolically healthy obesity: facts and fantasies. J Clin Invest. 2019 Oct 1;129(10):3978-89. PubMed DOI
Ogorodnikova AD, Kim M, McGinn AP, Muntner P, Khan U, Wildman RP. Incident cardiovascular disease events in metabolically benign obese individuals. Obesity (Silver Spring). 2012 Mar;20(3):651-9. PubMed DOI
Mongraw-Chaffin M, Foster MC, Anderson CAM, Burke GL, Haq N, Kalyani RR, et al. Metabolically healthy obesity, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 2018 May 1;71(17):1857-65. PubMed DOI
Lin H, Zhang L, Zheng R, Zheng Y. The prevalence, metabolic risk and effects of lifestyle intervention for metabolically healthy obesity: a systematic review and meta-analysis: a PRISMA-compliant article. Medicine (Baltimore). 2017 Nov;96(47):e8838. doi: 10.1097/MD.0000000000008838. PubMed DOI
Eckel N, Meidtner K, Kalle-Uhlmann T, Stefan N, Schulze MB. Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis. Eur J Prev Cardiol. 2016 Jun;23(9):956-66. PubMed DOI
Huang MY, Wang MY, Lin YS, Lin CJ, Lo K, Chang IJ, et al. The Association between metabolically healthy obesity, cardiovascular disease, and all-cause mortality risk in Asia: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020 Feb 19;17(4):1320. doi: 10.3390/ijerph17041320. PubMed DOI
Zheng R, Zhou D, Zhu Y. The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis. J Epidemiol Community Health. 2016 Oct;70(10):1024-31. PubMed DOI
Yeh TL, Chen HH, Tsai SY, Lin CY, Liu SJ, Chien KL. The Relationship between metabolically healthy obesity and the risk of cardiovascular disease: a systematic review and meta-analysis. J Clin Med. 2019 Aug 15;8(8):1228. doi: 10.3390/jcm8081228. PubMed DOI
Abiri B, Koohi F, Ebadinejad A, Valizadeh M, Hosseinpanah F. Transition from metabolically healthy to unhealthy overweight/obesity and risk of cardiovascular disease incidence: a systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2022 Sep;32(9):2041-51. PubMed DOI
Opio J, Croker E, Odongo GS, Attia J, Wynne K, McEvoy M. Metabolically healthy overweight/obesity are associated with increased risk of cardiovascular disease in adults, even in the absence of metabolic risk factors: a systematic review and meta-analysis of prospective cohort studies. Obes Rev. 2020 Dec;21(12):e13127. doi: 10.1111/obr.13127. PubMed DOI
Ma LZ, Sun FR, Wang ZT, Tan L, Hou XH, Ou YN, et al. Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies. Ann Transl Med. 2021 Feb;9(3):197. doi: 10.21037/atm-20-4387. PubMed DOI
Hsueh YW, Yeh TL, Lin CY, Tsai SY, Liu SJ, Lin CM, et al. Association of metabolically healthy obesity and elevated risk of coronary artery calcification: a systematic review and meta-analysis. PeerJ. 2020 Mar 26;8:e8815. doi: 10.7717/peerj.8815. PubMed DOI
Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies. Obes Rev. 2014 Jun;15(6):504-15. PubMed DOI
Hashimoto Y, Hamaguchi M, Tanaka M, Obora A, Kojima T, Fukui M. Metabolically healthy obesity without fatty liver and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies. Obes Res Clin Pract. 2018 Jan-Feb;12(1):4-15. PubMed DOI
Lin CJ, Chang YC, Cheng TY, Lo K, Liu SJ, Yeh TL. The association between metabolically healthy obesity and risk of cancer: a systematic review and meta-analysis of prospective cohort studies. Obes Rev. 2020 Oct;21(10):e13049. doi: 10.1111/obr.13049. PubMed DOI
Goodarzi G, Mozaffari H, Raeisi T, Mehravar F, Razi B, Ghazi ML, et al. Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies. BMC Cancer. 2022 Jan 21;22(1):89. doi: 10.1186/s12885-021-09149-w. PubMed DOI
Zheng X, Peng R, Xu H, Lin T, Qiu S, Wei Q, et al. The Association between metabolic status and risk of cancer among patients with obesity: metabolically healthy obesity vs. metabolically unhealthy obesity. Front Nutr. 2022 Feb 25;9:783660. doi: 10.3389/fnut.2022.783660. PubMed DOI
Kanbay M, Copur S, Siriopol D, Yildiz AB, Berkkan M, Tuttle KR, et al. The risk for chronic kidney disease in metabolically healthy obese patients: a systematic review and meta-analysis. Eur J Clin Invest. 2023 Jan;53(1):e13878. doi: 10.1111/eci.13878. PubMed DOI
Chen YY, Fang WH, Wang CC, Kao TW, Chang YW, Wu CJ, et al. Body fat has stronger associations with bone mass density than body mass index in metabolically healthy obesity. PLoS One. 2018 Nov 8;13(11):e0206812. doi: 10.1371/journal.pone.0206812. PubMed DOI
Migliaccio S, Greco EA, Fornari R, Donini LM, Lenzi A. Is obesity in women protective against osteoporosis? Diabetes Metab Syndr Obes. 2011;4:273-82. PubMed DOI
Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res. 2011 Jun 15;6:30. doi: 10.1186/1749-799X-6-30. PubMed DOI
Jokela M, Hamer M, Singh-Manoux A, Batty GD, Kivimäki M. Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies. Mol Psychiatry. 2014 Aug;19(8):910-4. PubMed DOI
Hart SM, Keirns BH, Sciarrillo CM, Malin SK, Kurti SP, Emerson SR. Cardiorespiratory fitness and submaximal exercise dynamics in normal-weight obesity and metabolically healthy obesity. Eur J Appl Physiol. 2023 Nov 2. doi: 10.1007/s00421-023-05344-8. PubMed DOI
Ortega FB, Cadenas-Sanchez C, Migueles JH, Labayen I, Ruiz JR, Sui X, et al. Role of physical activity and fitness in the characterization and prognosis of the metabolically healthy obesity phenotype: a systematic review and meta-analysis. Prog Cardiovasc Dis. 2018 Jul-Aug;61(2):190-205. PubMed DOI
Jinks C, Jordan K, Croft P. Disabling knee pain - another consequence of obesity: results from a prospective cohort study. BMC Public Health. 2006 Oct 19;6:258. doi: 10.1186/1471-2458-6-258. PubMed DOI
Shiri R, Karppinen J, Leino-Arjas P, Solovieva S, Viikari-Juntura E. The Association between obesity and low back pain: a meta-analysis. Am J Epidemiol. 2010 Jan 15;171(2):135-54. PubMed DOI
Silverwood V, Blagojevic-Bucknall M, Jinks C, Jordan JL, Protheroe J, Jordan KP. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015 Apr;23(4):507-15. PubMed DOI
Darlenski R, Mihaylova V, Handjieva-Darlenska T. The Link between obesity and the skin. Front Nutr. 2022 Mar 10;9:855573. doi: 10.3389/fnut.2022.855573. PubMed DOI
Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet. 2014 Feb 22;383(9918):736-47. PubMed DOI