PURPOSE: To develop a deep learning tool for the automatic segmentation of T2-weighted intramedullary lesions in spinal cord injury (SCI). MATERIAL AND METHODS: This retrospective study included a cohort of SCI patients from three sites enrolled between July 2002 and February 2023. A deep learning model, SCIseg, was trained in a three-phase process involving active learning for the automatic segmentation of intramedullary SCI lesions and the spinal cord. The data consisted of T2-weighted MRI acquired using different scanner manufacturers with heterogeneous image resolutions (isotropic/anisotropic), orientations (axial/sagittal), lesion etiologies (traumatic/ischemic/hemorrhagic) and lesions spread across the cervical, thoracic and lumbar spine. The segmentations from the proposed model were visually and quantitatively compared with other open-source baselines. Wilcoxon signed-rank test was used to compare quantitative MRI biomarkers (lesion volume, lesion length, and maximal axial damage ratio) computed from manual lesion masks and those obtained automatically with SCIseg predictions. RESULTS: MRI data from 191 SCI patients (mean age, 48.1 years ± 17.9 [SD]; 142 males) were used for model training and evaluation. SCIseg achieved the best segmentation performance for both the cord and lesions. There was no statistically significant difference between lesion length and maximal axial damage ratio computed from manually annotated lesions and those obtained using SCIseg. CONCLUSION: Automatic segmentation of intramedullary lesions commonly seen in SCI replaces the tedious manual annotation process and enables the extraction of relevant lesion morphometrics in large cohorts. The proposed model segments lesions across different etiologies, scanner manufacturers, and heterogeneous image resolutions. SCIseg is open-source and accessible through the Spinal Cord Toolbox.

Centre de Recherche du CHU Sainte Justine Université de Montréal Montreal QC Canada

Department of Anesthesiology Perioperative and Pain Medicine Stanford University School of Medicine Stanford California USA

Department of Neurology Faculty of Medicine and Dentistry Palacký University Olomouc Olomouc Czechia

Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany

Department of Neurosurgery Faculty of Medicine and Dentistry Palacký University Olomouc Olomouc Czechia

Department of Physical Medicine and Rehabilitation Physical Therapy Program University of Colorado School of Medicine Aurora Colorado USA

Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada

Mila Quebec AI Institute Montreal QC Canada

NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada

Spinal Cord Injury Center Balgrist University Hospital University of Zürich Zürich Switzerland

Radiol Artif Intell. 2025 Jan;7(1):e240005. doi: 10.1148/ryai.240005. PubMed

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