Influence of fentanyl, medetomidine-fentanyl or acepromazine-fentanyl premedication on oesophageal and rectal temperature in dogs under anaesthesia
Language English Country United States Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Veterinary
PubMed
38772852
DOI
10.1016/j.vaa.2024.04.003
PII: S1467-2987(24)00045-X
Knihovny.cz E-resources
- Keywords
- heat loss, hypothermia, neuroleptic, opioid, temperature, α(2)-adrenoceptor agonist,
- MeSH
- Acepromazine * pharmacology administration & dosage MeSH
- Anesthetics, Intravenous pharmacology administration & dosage MeSH
- Anesthesia, General veterinary MeSH
- Esophagus drug effects MeSH
- Fentanyl * pharmacology administration & dosage MeSH
- Anesthetics, Combined administration & dosage pharmacology MeSH
- Medetomidine * pharmacology administration & dosage MeSH
- Preanesthetic Medication veterinary MeSH
- Prospective Studies MeSH
- Dogs MeSH
- Rectum MeSH
- Body Temperature * drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Dogs MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Randomized Controlled Trial, Veterinary MeSH
- Names of Substances
- Acepromazine * MeSH
- Anesthetics, Intravenous MeSH
- Fentanyl * MeSH
- Anesthetics, Combined MeSH
- Medetomidine * MeSH
OBJECTIVE: To compare changes in oesophageal (T-Oeso) and rectal (T-Rec) temperature in dogs during general anaesthesia and premedicated with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl. STUDY DESIGN: Prospective, randomized, blind clinical study. ANIMALS: A total of 120 healthy dogs, aged 2-10 years and weighing 5-20 kg. METHODS: Dogs were randomly allocated to one of three groups. Animals of F group were premedicated with fentanyl (0.01 mg kg-1), MF group with medetomidine (0.005 mg kg-1) and fentanyl (0.01 mg kg-1) and AF group with acepromazine (0.01 mg kg-1) and fentanyl (0.01 mg kg-1). Anaesthesia was induced with propofol and maintained with isoflurane in oxygen-air mixture. Fentanyl was administered continuously (0.01 mg kg-1 hour-1). The T-Oeso, T-Rec and ambient temperatures were recorded after induction (T0) and subsequently at 10 minute intervals for 60 minutes (T10-T60). Data were analysed using anova or their non-parametric equivalents (p < 0.05). RESULTS: Median T-Oeso was significantly higher in MF group between T0-T20 compared with other groups. Median T-Oeso significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T30), 37.1 °C (T40), 36.9 °C (T50) and 36.6 °C (T60), in MF group from 38.3 °C (T0) to 37.7 °C (T30), 37.5 °C (T40), 37.2 °C (T50) and 37.1 °C (T60) and in AF group from 37.7 °C (T0) to 37.3 °C (T40), 37.2 °C (T50) and 37.1 °C (T60). The T-Rec significantly decreased in F group from 38.0 °C (T0) to 37.4 °C (T40), 37.2 °C (T50) and 36.9 °C (T60), in MF group from 38.3 °C (T0) to 37.5 °C (T50) and 37.4 °C (T60) and in AF group from 38.2 °C (T0) to 37.6 °C (T40), 37.5 °C (T50) and 37.4 °C (T60). CONCLUSIONS AND CLINICAL RELEVANCE: Premedication with fentanyl, medetomidine-fentanyl or acepromazine-fentanyl in the doses used decreased the T-Oeso and T-Rec. The T-Oeso at the beginning of anaesthesia was higher after premedication with medetomidine-fentanyl. However, this difference was not clinically significant.
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