The demographic profile of patients transitioning from chronic kidney disease to kidney replacement therapy is changing, with a higher prevalence of aging patients with multiple comorbidities such as diabetes mellitus and heart failure. Cardiovascular disease remains the leading cause of mortality in this population, exacerbated by the cardiovascular stress imposed by the HD procedure. The first year after transitioning to hemodialysis is associated with increased risks of hospitalization and mortality, particularly within the first 90-120 days, with greater vulnerability observed among the elderly. Based on data from clinics in Fresenius Medical Care Europe, Middle East, and Africa NephroCare, this review aims to optimize hemodialysis procedures to reduce mortality risk in stable incident and prevalent patients. It addresses critical aspects such as treatment duration, frequency, choice of dialysis membrane, dialysate composition, blood and dialysate flow rates, electrolyte composition, temperature control, target weight management, dialysis adequacy, and additional protocols, with a focus on mitigating prevalent intradialytic complications, particularly intradialytic hypotension prevention.

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Jager K.J., Kovesdy C., Langham R., Rosenberg M., Jha V., Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int. 2019;96:1048–1050. doi: 10.1016/j.kint.2019.07.012. PubMed DOI

Bello A.K., Okpechi I.G., Levin A., Ye F., Damster S., Arruebo S., Donner J.A., Caskey F.J., Cho Y., Davids M.R., et al. An update on the global disparities in kidney disease burden and care across world countries and regions. Lancet Glob. Health. 2024;12:e382–e395. doi: 10.1016/S2214-109X(23)00570-3. PubMed DOI

Kuipers J., Verboom L.M., Ipema K.J.R., Paans W., Krijnen W.P., Gaillard C., Westerhuis R., Franssen C.F.M. The Prevalence of Intradialytic Hypotension in Patients on Conventional Hemodialysis: A Systematic Review with Meta-Analysis. Am. J. Nephrol. 2019;49:497–506. doi: 10.1159/000500877. PubMed DOI PMC

Ducharlet K., Weil J., Gock H., Philip J. Kidney Clinicians’ Perceptions of Challenges and Aspirations to Improve End-of-Life Care Provision. Kidney Int. Rep. 2023;8:1627–1637. doi: 10.1016/j.ekir.2023.04.031. PubMed DOI PMC

Lin E., Ginsburg P.B., Chertow G.M., Berns J.S. The “Advancing American Kidney Health” Executive Order: Challenges and Opportunities for the Large Dialysis Organizations. Am. J. Kidney Dis. 2020;76:731–734. doi: 10.1053/j.ajkd.2020.07.007. PubMed DOI PMC

Bleyer A.J., Russell G.B., Satko S.G. Sudden and cardiac death rates in hemodialysis patients. Kidney Int. 1999;55:1553–1559. doi: 10.1046/j.1523-1755.1999.00391.x. PubMed DOI

Foley R.N. Clinical epidemiology of cardiac disease in dialysis patients: Left ventricular hypertrophy, ischemic heart disease, and cardiac failure. Semin. Dial. 2003;16:111–117. doi: 10.1046/j.1525-139x.2003.160271.x. PubMed DOI

McIntyre C.W. Update on Hemodialysis-Induced Multiorgan Ischemia: Brains and Beyond. J. Am. Soc. Nephrol. 2024;35:653–664. doi: 10.1681/ASN.0000000000000299. PubMed DOI PMC

Tonelli M., Karumanchi S.A., Thadhani R. Epidemiology and Mechanisms of Uremia-Related Cardiovascular Disease. Circulation. 2016;133:518–536. doi: 10.1161/CIRCULATIONAHA.115.018713. PubMed DOI

Odudu A., McIntyre C.W. An Update on Intradialytic Cardiac Dysfunction. Semin. Dial. 2016;29:435–441. doi: 10.1111/sdi.12532. PubMed DOI

Broers N.J., Cuijpers A.C., van der Sande F.M., Leunissen K.M., Kooman J.P. The first year on haemodialysis: A critical transition. Clin. Kidney J. 2015;8:271–277. doi: 10.1093/ckj/sfv021. PubMed DOI PMC

Maddux D.W., Usvyat L.A., Ketchersid T., Jiao Y., Blanchard T.C., Kotanko P., van der Sande F.M., Kooman J.P., Maddux F.W. Clinical parameters before and after the transition to dialysis. Hemodial. Int. Int. Symp. Home Hemodial. 2018;22:235–244. doi: 10.1111/hdi.12603. PubMed DOI

Wong S.P., Kreuter W., O’Hare A.M. Healthcare intensity at initiation of chronic dialysis among older adults. J. Am. Soc. Nephrol. 2014;25:143–149. doi: 10.1681/asn.2013050491. PubMed DOI PMC

Dashtban A., Mizani M.A., Denaxas S., Nitsch D., Quint J., Corbett R., Mamza J.B., Morris T., Mamas M., Lawlor D.A., et al. A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease. Kidney Int. 2022;102:652–660. doi: 10.1016/j.kint.2022.05.015. PubMed DOI PMC

Garbelli M., Ion-Titapiccolo J., Bellocchio F., Stuard S., Brancaccio D., Neri L. Prolonged patient survival after implementation of a continuous quality improvement programme empowered by digital transformation in a large dialysis network. Nephrol. Dial. Transplant. 2022;37:469–476. doi: 10.1093/ndt/gfab160. PubMed DOI

Assimon M.M., Flythe J.E. Definitions of intradialytic hypotension. Semin. Dial. 2017;30:464–472. doi: 10.1111/sdi.12626. PubMed DOI PMC

Workgroup K.D. K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am. J. Kidney Dis. 2005;45:S1–S153. PubMed

Kooman J., Basci A., Pizzarelli F., Canaud B., Haage P., Fouque D., Konner K., Martin-Malo A., Pedrini L., Tattersall J., et al. EBPG guideline on haemodynamic instability. Nephrol. Dial. Transplant. 2007;22((Suppl. S2)):ii22–ii44. doi: 10.1093/ndt/gfm019. PubMed DOI

Mactier R., Hoenich N., Breen C. UK Renal Association Clinical Practice Guidelines: Haemodialysis 5th Edition. Guideline 8.1—HD: Symptomatic Dialysis-Related Hypotension Haemodialysis. 2009. [(accessed on 19 May 2024)]. Available online: https://ukkidney.org/sites/renal.org/files/haemodialysis-5th-edition.pdf.

Hirakata H., Nitta K., Inaba M., Shoji T., Fujii H., Kobayashi S., Tabei K., Joki N., Hase H., Nishimura M., et al. Japanese Society for Dialysis Therapy guidelines for management of cardiovascular diseases in patients on chronic hemodialysis. Ther. Apher. Dial. 2012;16:387–435. doi: 10.1111/j.1744-9987.2012.01088.x. PubMed DOI

Sands J.J., Usvyat L.A., Sullivan T., Segal J.H., Zabetakis P., Kotanko P., Maddux F.W., Diaz-Buxo J.A. Intradialytic hypotension: Frequency, sources of variation and correlation with clinical outcome. Hemodial. Int. Int. Symp. Home Hemodial. 2014;18:415–422. doi: 10.1111/hdi.12138. PubMed DOI

Reilly R.F. Attending rounds: A patient with intradialytic hypotension. Clin. J. Am. Soc. Nephrol. 2014;9:798–803. doi: 10.2215/CJN.09930913. PubMed DOI PMC

Davenport A. Why is Intradialytic Hypotension the Commonest Complication of Outpatient Dialysis Treatments? Kidney Int. Rep. 2023;8:405–418. doi: 10.1016/j.ekir.2022.10.031. PubMed DOI PMC

Daugirdas J.T. Pathophysiology of dialysis hypotension: An update. Am. J. Kidney Dis. 2001;38:S11–S17. doi: 10.1053/ajkd.2001.28090. PubMed DOI

Kanbay M., Ertuglu L.A., Afsar B., Ozdogan E., Siriopol D., Covic A., Basile C., Ortiz A. An update review of intradialytic hypotension: Concept, risk factors, clinical implications and management. Clin. Kidney J. 2020;13:981–993. doi: 10.1093/ckj/sfaa078. PubMed DOI PMC

Shoji T., Tsubakihara Y., Fujii M., Imai E. Hemodialysis-associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int. 2004;66:1212–1220. doi: 10.1111/j.1523-1755.2004.00812.x. PubMed DOI

Assa S., Hummel Y.M., Voors A.A., Kuipers J., Westerhuis R., de Jong P.E., Franssen C.F. Hemodialysis-induced regional left ventricular systolic dysfunction: Prevalence, patient and dialysis treatment-related factors, and prognostic significance. Clin. J. Am. Soc. Nephrol. 2012;7:1615–1623. doi: 10.2215/CJN.00850112. PubMed DOI PMC

Flythe J.E., Xue H., Lynch K.E., Curhan G.C., Brunelli S.M. Association of mortality risk with various definitions of intradialytic hypotension. J. Am. Soc. Nephrol. 2015;26:724–734. doi: 10.1681/ASN.2014020222. PubMed DOI PMC

Burton J.O., Jefferies H.J., Selby N.M., McIntyre C.W. Hemodialysis-induced repetitive myocardial injury results in global and segmental reduction in systolic cardiac function. Clin. J. Am. Soc. Nephrol. 2009;4:1925–1931. doi: 10.2215/CJN.04470709. PubMed DOI PMC

Tisler A., Akocsi K., Borbas B., Fazakas L., Ferenczi S., Gorogh S., Kulcsar I., Nagy L., Samik J., Szegedi J., et al. The effect of frequent or occasional dialysis-associated hypotension on survival of patients on maintenance haemodialysis. Nephrol. Dial. Transplant. 2003;18:2601–2605. doi: 10.1093/ndt/gfg450. PubMed DOI

van der Sande F.M., Dekker M.J., Leunissen K.M.L., Kooman J.P. Novel Insights into the Pathogenesis and Prevention of Intradialytic Hypotension. Blood Purif. 2018;45:230–235. doi: 10.1159/000485160. PubMed DOI PMC

Barth C., Boer W., Garzoni D., Kuenzi T., Ries W., Schaefer R., Schneditz D., Tsobanelis T., van der Sande F., Wojke R., et al. Characteristics of hypotension-prone haemodialysis patients: Is there a critical relative blood volume? Nephrol. Dial. Transplant. 2003;18:1353–1360. doi: 10.1093/ndt/gfg171. PubMed DOI

Worthley L.I. Shock: A review of pathophysiology and management. Part II. Crit. Care Resusc. 2000;2:66–84. doi: 10.1016/S1441-2772(23)02124-5. PubMed DOI

Funk D.J., Jacobsohn E., Kumar A. The role of venous return in critical illness and shock-part I: Physiology. Crit. Care Med. 2013;41:255–262. doi: 10.1097/CCM.0b013e3182772ab6. PubMed DOI

Montgomery L.D., Montgomery R.W., Gerth W.A., Lew S.Q., Klein M.D., Stewart J.M., Medow M.S., Velasquez M.T. Bioimpedance monitoring of cellular hydration during hemodialysis therapy. Hemodial. Int. Int. Symp. Home Hemodial. 2017;21:575–584. doi: 10.1111/hdi.12511. PubMed DOI PMC

Tattersall J., Martin-Malo A., Pedrini L., Basci A., Canaud B., Fouque D., Haage P., Konner K., Kooman J., Pizzarelli F., et al. EBPG guideline on dialysis strategies. Nephrol. Dial. Transplant. 2007;22((Suppl. S2)):ii5–ii21. doi: 10.1093/ndt/gfm022. PubMed DOI

Ashby D., Borman N., Burton J., Corbett R., Davenport A., Farrington K., Flowers K., Fotheringham J., Andrea Fox R.N., Franklin G., et al. Renal Association Clinical Practice Guideline on Haemodialysis. BMC Nephrol. 2019;20:379. doi: 10.1186/s12882-019-1527-3. PubMed DOI PMC

National Kidney Foundation KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update. Am. J. Kidney Dis. 2015;66:884–930. doi: 10.1053/j.ajkd.2015.07.015. PubMed DOI

Tentori F., Zhang J., Li Y., Karaboyas A., Kerr P., Saran R., Bommer J., Port F., Akiba T., Pisoni R., et al. Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS) Nephrol. Dial. Transplant. 2012;27:4180–4188. doi: 10.1093/ndt/gfs021. PubMed DOI PMC

Yamamoto M., Matsumoto T., Ohmori H., Takemoto M., Ikeda M., Sumimoto R., Kobayashi T., Kato A., Ohdan H. Effect of increased blood flow rate on renal anemia and hepcidin concentration in hemodialysis patients. BMC Nephrol. 2021;22:221. doi: 10.1186/s12882-021-02426-7. PubMed DOI PMC

Leypoldt J.K., Cheung A.K., Agodoa L.Y., Daugirdas J.T., Greene T., Keshaviah P.R. Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates. The Hemodialysis (HEMO) Study. Kidney Int. 1997;51:2013–2017. doi: 10.1038/ki.1997.274. PubMed DOI

Albalate M., Pérez-García R., de Sequera P., Corchete E., Alcazar R., Ortega M., Puerta M. Is it useful to increase dialysate flow rate to improve the delivered Kt? BMC Nephrol. 2015;16:20. doi: 10.1186/s12882-015-0013-9. PubMed DOI PMC

Mesic E., Bock A., Major L., Vaslaki L., Berta K., Wikstrom B., Canaud B., Wojke R. Dialysate saving by automated control of flow rates: Comparison between individualized online hemodiafiltration and standard hemodialysis. Hemodial. Int. Int. Symp. Home Hemodial. 2011;15:522–529. doi: 10.1111/j.1542-4758.2011.00577.x. PubMed DOI

Locatelli F., Covic A., Chazot C., Leunissen K., Luño J., Yaqoob M. Optimal composition of the dialysate, with emphasis on its influence on blood pressure. Nephrol. Dial. Transplant. 2004;19:785–796. doi: 10.1093/ndt/gfh102. PubMed DOI

Lindley E.J. Reducing sodium intake in hemodialysis patients. Semin. Dial. 2009;22:260–263. doi: 10.1111/j.1525-139X.2009.00570.x. PubMed DOI

Raimann J.G., Thijssen S., Usvyat L.A., Levin N.W., Kotanko P. Sodium alignment in clinical practice—Implementation and implications. Semin. Dial. 2011;24:587–592. doi: 10.1111/j.1525-139X.2011.00973.x. PubMed DOI

Canaud B., Kooman J., Selby N.M., Taal M., Francis S., Kopperschmidt P., Maierhofer A., Kotanko P., Titze J. Sodium and water handling during hemodialysis: New pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease. Kidney Int. 2019;95:296–309. doi: 10.1016/j.kint.2018.09.024. PubMed DOI

Hussein W.F., Schiller B. Dialysate sodium and intradialytic hypotension. Semin. Dial. 2017;30:492–500. doi: 10.1111/sdi.12634. PubMed DOI

Locatelli F., La Milia V., Violo L., Del Vecchio L., Di Filippo S. Optimizing haemodialysate composition. Clin. Kidney J. 2015;8:580–589. doi: 10.1093/ckj/sfv057. PubMed DOI PMC

Miskulin D.C., Tighiouart H., Hsu C.M., Weiner D.E. Dialysate Sodium Lowering in Maintenance Hemodialysis A Randomized Clinical Trial. Clin. J. Am. Soc. Nephrol. 2024 doi: 10.2215/cjn.0000000000000431. PubMed DOI PMC

Lindley E., Tattersall J. What Is the Optimal Dialysate Sodium Concentration? Kidney Dial. 2021;1:157–160. doi: 10.3390/kidneydial1020022. DOI

Hecking M., Karaboyas A., Rayner H., Saran R., Sen A., Inaba M., Bommer J., Hörl W.H., Pisoni R.L., Robinson B.M., et al. Dialysate sodium prescription and blood pressure in hemodialysis patients. Am. J. Hypertens. 2014;27:1160–1169. doi: 10.1093/ajh/hpu040. PubMed DOI

Canaud B. A Personal and Practical Answer From a Clinical Perspective. Kidney Dial. 2021;1:149–151. doi: 10.3390/kidneydial1020019. DOI

Canaud B., Kooman J., Maierhofer A., Raimann J., Titze J., Kotanko P. Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes. Front. Nephrol. 2022;2:935388. doi: 10.3389/fneph.2022.935388. PubMed DOI PMC

Raimann J.G., Ficociello L.H., Usvyat L.A., Zhang H., Pacelli L., Moore S., Sheppard P., Xiao Q., Wang Y., Mullon C., et al. Effects of dialysate to serum sodium (Na(+)) alignment in chronic hemodialysis (HD) patients: Retrospective cohort study from a quality improvement project. BMC Nephrol. 2018;19:75. doi: 10.1186/s12882-018-0870-0. PubMed DOI PMC

Kuhlmann U., Maierhofer A., Canaud B., Hoyer J., Gross M. Zero Diffusive Sodium Balance in Hemodialysis Provided by an Algorithm-Based Electrolyte Balancing Controller: A Proof of Principle Clinical Study. Artif. Organs. 2019;43:150–158. doi: 10.1111/aor.13328. PubMed DOI

Ponce P., Pinto B., Wojke R., Maierhofer A.P., Gauly A. Evaluation of intradialytic sodium shifts during sodium controlled hemodialysis. Int. J. Artif. Organs. 2020;43:620–624. doi: 10.1177/0391398820903055. PubMed DOI

Sagova M., Wojke R., Maierhofer A., Gross M., Canaud B., Gauly A. Automated individualization of dialysate sodium concentration reduces intradialytic plasma sodium changes in hemodialysis. Artif. Organs. 2019;43:1002–1013. doi: 10.1111/aor.13463. PubMed DOI PMC

Leunissen K.M., van den Berg B.W., van Hooff J.P. Ionized calcium plays a pivotal role in controlling blood pressure during haemodialysis. Blood Purif. 1989;7:233–239. doi: 10.1159/000169600. PubMed DOI

Tovbin D., Sherman R.A. Correcting Acidosis during Hemodialysis: Current Limitations and a Potential Solution. Semin. Dial. 2016;29:35–38. doi: 10.1111/sdi.12454. PubMed DOI

Abramowitz M.K. Bicarbonate Balance and Prescription in ESRD. J. Am. Soc. Nephrol. 2017;28:726–734. doi: 10.1681/ASN.2016070780. PubMed DOI PMC

Lomashvili K., Garg P., O’Neill W.C. Chemical and hormonal determinants of vascular calcification in vitro. Kidney Int. 2006;69:1464–1470. doi: 10.1038/sj.ki.5000297. PubMed DOI

Mendoza F.J., Lopez I., Montes de Oca A., Perez J., Rodriguez M., Aguilera-Tejero E. Metabolic acidosis inhibits soft tissue calcification in uremic rats. Kidney Int. 2008;73:407–414. doi: 10.1038/sj.ki.5002646. PubMed DOI

Mudunuru S.A., Navarrete J., O’Neill W.C. Metabolic alkalosis in hemodialysis patients. Semin. Dial. 2023;36:24–28. doi: 10.1111/sdi.13068. PubMed DOI

Qian Q. Acid-base alterations in ESRD and effects of hemodialysis. Semin. Dial. 2018;31:226–235. doi: 10.1111/sdi.12659. PubMed DOI

Bozikas A., Kiriakoutzik I., Petrou I., Touroutzis T., Kitoukidi E., Pisanidou P., Vakiani S., Georgilas N., Martika A., Pangidis P., et al. Aiming for the optimal bicarbonate prescription for maintenance hemodialysis therapy in end-stage renal disease. Hemodial. Int. Int. Symp. Home Hemodial. 2019;23:173–180. doi: 10.1111/hdi.12710. PubMed DOI

Yokoyama A., Kikuchi K., Kawamura Y. Heart rate variability, arrhythmia and magnesium in hemodialysis patients. Clin. Calcium. 2005;15:226–232. PubMed

Wieliczko M., Małyszko J. Acid-base balance in hemodialysis patients in everyday practice. Ren. Fail. 2022;44:1090–1097. doi: 10.1080/0886022x.2022.2094805. PubMed DOI PMC

Tentori F., Karaboyas A., Robinson B.M., Morgenstern H., Zhang J., Sen A., Ikizler T.A., Rayner H., Fissell R.B., Vanholder R., et al. Association of dialysate bicarbonate concentration with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS) Am. J. Kidney Dis. 2013;62:738–746. doi: 10.1053/j.ajkd.2013.03.035. PubMed DOI PMC

Gabutti L., Ferrari N., Giudici G., Mombelli G., Marone C. Unexpected haemodynamic instability associated with standard bicarbonate haemodialysis. Nephrol. Dial. Transplant. 2003;18:2369–2376. doi: 10.1093/ndt/gfg383. PubMed DOI

K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am. J. Kidney Dis. 2003;42:S1–S201. doi: 10.1016/S0272-6386(03)00905-3. PubMed DOI

Drüeke T.B., Touam M. Calcium balance in haemodialysis--do not lower the dialysate calcium concentration too much (con part) Nephrol. Dial. Transplant. 2009;24:2990–2993. doi: 10.1093/ndt/gfp365. PubMed DOI

Maynard J.C., Cruz C., Kleerekoper M., Levin N.W. Blood pressure response to changes in serum ionized calcium during hemodialysis. Ann. Intern. Med. 1986;104:358–361. doi: 10.7326/0003-4819-104-3-358. PubMed DOI

van der Sande F.M., Cheriex E.C., van Kuijk W.H., Leunissen K.M. Effect of dialysate calcium concentrations on intradialytic blood pressure course in cardiac-compromised patients. Am. J. Kidney Dis. 1998;32:125–131. doi: 10.1053/ajkd.1998.v32.pm9669433. PubMed DOI

Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Kidney Int. Suppl. 2017;7:1–59. doi: 10.1016/j.kisu.2017.10.001. Erratum in Kidney Int. Suppl. 2017, 7, e1. PubMed DOI PMC

Ketteler M., Block G.A., Evenepoel P., Fukagawa M., Herzog C.A., McCann L., Moe S.M., Shroff R., Tonelli M.A., Toussaint N.D., et al. Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: What’s changed and why it matters. Kidney Int. 2017;92:26–36. doi: 10.1016/j.kint.2017.04.006. PubMed DOI

McGill R.L., Weiner D.E. Dialysate Composition for Hemodialysis: Changes and Changing Risk. Semin. Dial. 2017;30:112–120. doi: 10.1111/sdi.12573. PubMed DOI PMC

Pun P.H., Horton J.R., Middleton J.P. Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2013;8:797–803. doi: 10.2215/CJN.10000912. PubMed DOI PMC

Jimenez Z.N., Silva B.C., Reis L.D., Castro M.C., Ramos C.D., Costa-Hong V., Bortolotto L.A., Consolim-Colombo F., Dominguez W.V., Oliveira I.B., et al. High Dialysate Calcium Concentration May Cause More Sympathetic Stimulus During Hemodialysis. Kidney Blood Press. Res. 2016;41:978–985. doi: 10.1159/000452601. PubMed DOI

Genovesi S., Rossi E., Nava M., Riva H., De Franceschi S., Fabbrini P., Viganò M.R., Pieruzzi F., Stella A., Valsecchi M.G., et al. A case series of chronic haemodialysis patients: Mortality, sudden death, and QT interval. Europace. 2013;15:1025–1033. doi: 10.1093/europace/eus412. PubMed DOI

Yoshikawa M., Takase O., Tsujimura T., Sano E., Hayashi M., Takato T., Hishikawa K. Long-term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-analysis. Sci. Rep. 2018;8:5310. doi: 10.1038/s41598-018-23658-y. PubMed DOI PMC

Garimella P.S., Malhotra R. Dialysate Calcium: A Lot More Than ‘Set It and Forget It’. Kidney Med. 2019;1:238–241. doi: 10.1016/j.xkme.2019.05.005. PubMed DOI PMC

Sakoh T., Taniguchi M., Yamada S., Ohnaka S., Arase H., Tokumoto M., Yanagida T., Mitsuiki K., Hirakata H., Nakano T., et al. Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients: The K4 Study. Kidney Med. 2019;1:296–306. doi: 10.1016/j.xkme.2019.08.002. PubMed DOI PMC

van der Sande F.M., Ter Meulen K.J.A., Kotanko P., Kooman J.P. Dialysate Calcium Levels: Do They Matter? Blood Purif. 2019;47:230–235. doi: 10.1159/000494584. PubMed DOI

Voroneanu L., Covic A. Arrhythmias in hemodialysis patients. J. Nephrol. 2009;22:716–725. PubMed

Basile C., Lomonte C. A neglected issue in dialysis practice: Haemodialysate. Clin. Kidney J. 2015;8:393–399. doi: 10.1093/ckj/sfv038. PubMed DOI PMC

Basile C., Libutti P., Lisi P., Teutonico A., Vernaglione L., Casucci F., Lomonte C. Ranking of factors determining potassium mass balance in bicarbonate haemodialysis. Nephrol. Dial. Transplant. 2015;30:505–513. doi: 10.1093/ndt/gfu376. PubMed DOI

Feig P.U., Shook A., Sterns R.H. Effect of potassium removal during hemodialysis on the plasma potassium concentration. Nephron. 1981;27:25–30. doi: 10.1159/000182015. PubMed DOI

Zehnder C., Gutzwiller J.P., Huber A., Schindler C., Schneditz D. Low-potassium and glucose-free dialysis maintains urea but enhances potassium removal. Nephrol. Dial. Transplant. 2001;16:78–84. doi: 10.1093/ndt/16.1.78. PubMed DOI

Buemi M., Aloisi E., Coppolino G., Loddo S., Crasci E., Aloisi C., Barilla A., Cosentini V., Nostro L., Caccamo C., et al. The effect of two different protocols of potassium haemodiafiltration on QT dispersion. Nephrol. Dial. Transplant. 2005;20:1148–1154. doi: 10.1093/ndt/gfh770. PubMed DOI

Ansari N., Manis T., Feinfeld D.A. Symptomatic atrial arrhythmias in hemodialysis patients. Ren. Fail. 2001;23:71–76. doi: 10.1081/jdi-100001285. PubMed DOI

Morrison G., Michelson E.L., Brown S., Morganroth J. Mechanism and prevention of cardiac arrhythmias in chronic hemodialysis patients. Kidney Int. 1980;17:811–819. doi: 10.1038/ki.1980.93. PubMed DOI

Korzets A., Ori Y., Herman M. Serum potassium levels and atrial fibrillation in haemodialysis patients. Nephrol. Dial. Transplant. 2001;16:1090. doi: 10.1093/ndt/16.5.1090. PubMed DOI

Khouri Y., Stephens T., Ayuba G., AlAmeri H., Juratli N., McCullough P.A. Understanding and Managing Atrial Fibrillation in Patients with Kidney Disease. J. Atr. Fibrillation. 2015;7:1069. doi: 10.4022/jafib.1069. PubMed DOI PMC

Pun P.H., Lehrich R.W., Honeycutt E.F., Herzog C.A., Middleton J.P. Modifiable risk factors associated with sudden cardiac arrest within hemodialysis clinics. Kidney Int. 2011;79:218–227. doi: 10.1038/ki.2010.315. PubMed DOI

Karnik J.A., Young B.S., Lew N.L., Herget M., Dubinsky C., Lazarus J.M., Chertow G.M. Cardiac arrest and sudden death in dialysis units. Kidney Int. 2001;60:350–357. doi: 10.1046/j.1523-1755.2001.00806.x. PubMed DOI

Karaboyas A., Zee J., Brunelli S.M., Usvyat L.A., Weiner D.E., Maddux F.W., Nissenson A.R., Jadoul M., Locatelli F., Winkelmayer W.C., et al. Dialysate Potassium, Serum Potassium, Mortality, and Arrhythmia Events in Hemodialysis: Results From the Dialysis Outcomes and Practice Patterns Study (DOPPS) Am. J. Kidney Dis. 2017;69:266–277. doi: 10.1053/j.ajkd.2016.09.015. PubMed DOI PMC

Ikizler T.A., Burrowes J.D., Byham-Gray L.D., Campbell K.L., Carrero J.J., Chan W., Fouque D., Friedman A.N., Ghaddar S., Goldstein-Fuchs D.J., et al. KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. Am. J. Kidney Dis. 2020;76:S1–S107. doi: 10.1053/j.ajkd.2020.05.006. PubMed DOI

Elsharkawy M.M., Youssef A.M., Zayoon M.Y. Intradialytic changes of serum magnesium and their relation to hypotensive episodes in hemodialysis patients on different dialysates. Hemodial. Int. Int. Symp. Home Hemodial. 2006;10((Suppl. S2)):S16–S23. doi: 10.1111/j.1542-4758.2006.00120.x. PubMed DOI

Kyriazis J., Kalogeropoulou K., Bilirakis L., Smirnioudis N., Pikounis V., Stamatiadis D., Liolia E. Dialysate magnesium level and blood pressure. Kidney Int. 2004;66:1221–1231. doi: 10.1111/j.1523-1755.2004.00875.x. PubMed DOI

Floege J. Magnesium Concentration in Dialysate: Is Higher Better? Clin. J. Am. Soc. Nephrol. 2018;13:1309–1310. doi: 10.2215/cjn.08380718. PubMed DOI PMC

Alhosaini M., Leehey D.J. Magnesium and Dialysis: The Neglected Cation. Am. J. Kidney Dis. 2015;66:523–531. doi: 10.1053/j.ajkd.2015.01.029. PubMed DOI

Takahashi A., Kubota T., Shibahara N., Terasaki J., Kagitani M., Ueda H., Inoue T., Katsuoka Y. The mechanism of hypoglycemia caused by hemodialysis. Clin. Nephrol. 2004;62:362–368. doi: 10.5414/cnp62362. PubMed DOI

Jackson M.A., Holland M.R., Nicholas J., Talbot M., Spencer H., Lodwick R., Fuhrmann C., Forster D., Macdonald I.A. Occult hypoglycemia caused by hemodialysis. Clin. Nephrol. 1999;51:242–247. PubMed

Pizzarelli F. From cold dialysis to isothermic dialysis: A twenty-five year voyage. Nephrol. Dial. Transplant. 2007;22:1007–1012. doi: 10.1093/ndt/gfl822. PubMed DOI

Levy F.L., Grayburn P.A., Foulks C.J., Brickner M.E., Henrich W.L. Improved left ventricular contractility with cool temperature hemodialysis. Kidney Int. 1992;41:961–965. doi: 10.1038/ki.1992.147. PubMed DOI

Coli U., Landini S., Lucatello S., Fracasso A., Morachiello P., Righetto F., Scanferla F., Onesti G., Bazzato G. Cold as cardiovascular stabilizing factor in hemodialysis: Hemodynamic evaluation. Trans. Am. Soc. Artif. Intern. Organs. 1983;29:71–75. PubMed

Mahida B.H., Dumler F., Zasuwa G., Fleig G., Levin N.W. Effect of cooled dialysate on serum catecholamines and blood pressure stability. Trans. Am. Soc. Artif. Intern. Organs. 1983;29:384–389. PubMed

Selby N.M., Burton J.O., Chesterton L.J., McIntyre C.W. Dialysis-induced regional left ventricular dysfunction is ameliorated by cooling the dialysate. Clin. J. Am. Soc. Nephrol. 2006;1:1216–1225. doi: 10.2215/cjn.02010606. PubMed DOI

Selby N.M., McIntyre C.W. A systematic review of the clinical effects of reducing dialysate fluid temperature. Nephrol. Dial. Transplant. 2006;21:1883–1898. doi: 10.1093/ndt/gfl126. PubMed DOI

van der Sande F.M., Rosales L.M., Brener Z., Kooman J.P., Kuhlmann M., Handelman G., Greenwood R.N., Carter M., Schneditz D., Leunissen K.M., et al. Effect of ultrafiltration on thermal variables, skin temperature, skin blood flow, and energy expenditure during ultrapure hemodialysis. J. Am. Soc. Nephrol. 2005;16:1824–1831. doi: 10.1681/ASN.2004080655. PubMed DOI

Rosales L.M., Schneditz D., Morris A.T., Rahmati S., Levin N.W. Isothermic hemodialysis and ultrafiltration. Am. J. Kidney Dis. 2000;36:353–361. doi: 10.1053/ajkd.2000.8986. PubMed DOI

Maggiore Q., Pizzarelli F., Santoro A., Panzetta G., Bonforte G., Hannedouche T., Alvarez de Lara M.A., Tsouras I., Loureiro A., Ponce P., et al. The effects of control of thermal balance on vascular stability in hemodialysis patients: Results of the European randomized clinical trial. Am. J. Kidney Dis. 2002;40:280–290. doi: 10.1053/ajkd.2002.34506. PubMed DOI

Eldehni M.T., Odudu A., McIntyre C.W. Randomized clinical trial of dialysate cooling and effects on brain white matter. J. Am. Soc. Nephrol. 2015;26:957–965. doi: 10.1681/ASN.2013101086. PubMed DOI PMC

Selby N.M., Taal M.W. Evaluating the results of MyTEMP, a cluster randomised trial of lower temperature haemodialysis: The end of a cool idea? Lancet. 2022;400:1657–1659. doi: 10.1016/S0140-6736(22)01988-2. PubMed DOI

Zoccali C., Tripepi G., Neri L., Savoia M., Baró Salvador M.E., Ponce P., Hymes J., Maddux F., Mallamaci F., Stuard S. Effectiveness of cold HD for the prevention of HD hypotension and mortality in the general HD population. Nephrol. Dial. Transplant. 2023;38:1700–1706. doi: 10.1093/ndt/gfad003. PubMed DOI

Combe C., Rubin S. Cold haemodialysis: The instrumental power of large cohorts. Nephrol. Dial. Transplant. 2023;38:1577–1579. doi: 10.1093/ndt/gfad054. PubMed DOI

Odudu A., Eldehni M.T., McCann G.P., McIntyre C.W. Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients. Clin. J. Am. Soc. Nephrol. 2015;10:1408–1417. doi: 10.2215/CJN.00200115. PubMed DOI PMC

Sinha A.D., Agarwal R. Can chronic volume overload be recognized and prevented in hemodialysis patients? The pitfalls of the clinical examination in assessing volume status. Semin. Dial. 2009;22:480–482. doi: 10.1111/j.1525-139X.2009.00641.x. PubMed DOI

Hamrahian S.M., Vilayet S., Herberth J., Fülöp T. Prevention of Intradialytic Hypotension in Hemodialysis Patients: Current Challenges and Future Prospects. Int. J. Nephrol. Renov. Dis. 2023;16:173–181. doi: 10.2147/ijnrd.S245621. PubMed DOI PMC

Berger D., Takala J. Hypotension and hypovolemia during hemodialysis: Is the usual suspect innocent? Crit. Care. 2016;20:140. doi: 10.1186/s13054-016-1307-4. PubMed DOI PMC

Onofriescu M., Siriopol D., Voroneanu L., Hogas S., Nistor I., Apetrii M., Florea L., Veisa G., Mititiuc I., Kanbay M., et al. Overhydration, Cardiac Function and Survival in Hemodialysis Patients. PLoS ONE. 2015;10:e0135691. doi: 10.1371/journal.pone.0135691. PubMed DOI PMC

Fishbane S., Natke E., Maesaka J.K. Role of volume overload in dialysis-refractory hypertension. Am. J. Kidney Dis. 1996;28:257–261. doi: 10.1016/s0272-6386(96)90309-1. PubMed DOI

Wizemann V., Wabel P., Chamney P., Zaluska W., Moissl U., Rode C., Malecka-Masalska T., Marcelli D. The mortality risk of overhydration in haemodialysis patients. Nephrol. Dial. Transplant. 2009;24:1574–1579. doi: 10.1093/ndt/gfn707. PubMed DOI PMC

Zoccali C., Moissl U., Chazot C., Mallamaci F., Tripepi G., Arkossy O., Wabel P., Stuard S. Chronic Fluid Overload and Mortality in ESRD. J. Am. Soc. Nephrol. 2017;28:2491–2497. doi: 10.1681/ASN.2016121341. PubMed DOI PMC

Charra B., Bergstrom J., Scribner B.H. Blood pressure control in dialysis patients: Importance of the lag phenomenon. Am. J. Kidney Dis. 1998;32:720–724. doi: 10.1016/s0272-6386(98)70147-7. PubMed DOI

Arrigo M., Von Moos S., Gerritsen K., Sadoune M., Tangvoraphonkchai K., Davenport A., Mebazaa A., Segerer S., Cippà P.E. Soluble CD146 and B-type natriuretic peptide dissect overhydration into functional components of prognostic relevance in haemodialysis patients. Nephrol. Dial. Transplant. 2018;33:2035–2042. doi: 10.1093/ndt/gfy113. PubMed DOI

Moissl U.M., Wabel P., Chamney P.W., Bosaeus I., Levin N.W., Bosy-Westphal A., Korth O., Müller M.J., Ellegård L., Malmros V., et al. Body fluid volume determination via body composition spectroscopy in health and disease. Physiol. Meas. 2006;27:921–933. doi: 10.1088/0967-3334/27/9/012. PubMed DOI

Machek P., Jirka T., Moissl U., Chamney P., Wabel P. Guided optimization of fluid status in haemodialysis patients. Nephrol. Dial. Transplant. 2010;25:538–544. doi: 10.1093/ndt/gfp487. PubMed DOI PMC

Chamney P.W., Wabel P., Moissl U.M., Müller M.J., Bosy-Westphal A., Korth O., Fuller N.J. A whole-body model to distinguish excess fluid from the hydration of major body tissues. Am. J. Clin. Nutr. 2007;85:80–89. doi: 10.1093/ajcn/85.1.80. PubMed DOI

Movilli E., Gaggia P., Zubani R., Camerini C., Vizzardi V., Parrinello G., Savoldi S., Fischer M.S., Londrino F., Cancarini G. Association between high ultrafiltration rates and mortality in uraemic patients on regular haemodialysis. A 5-year prospective observational multicentre study. Nephrol. Dial. Transplant. 2007;22:3547–3552. doi: 10.1093/ndt/gfm466. PubMed DOI

Cheung A.K., Sarnak M.J., Yan G., Berkoben M., Heyka R., Kaufman A., Lewis J., Rocco M., Toto R., Windus D., et al. Cardiac diseases in maintenance hemodialysis patients: Results of the HEMO Study. Kidney Int. 2004;65:2380–2389. doi: 10.1111/j.1523-1755.2004.00657.x. PubMed DOI

Saran R., Bragg-Gresham J.L., Levin N.W., Twardowski Z.J., Wizemann V., Saito A., Kimata N., Gillespie B.W., Combe C., Bommer J., et al. Longer treatment time and slower ultrafiltration in hemodialysis: Associations with reduced mortality in the DOPPS. Kidney Int. 2006;69:1222–1228. doi: 10.1038/sj.ki.5000186. PubMed DOI

Flythe J.E., Kimmel S.E., Brunelli S.M. Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality. Kidney Int. 2011;79:250–257. doi: 10.1038/ki.2010.383. PubMed DOI PMC

NQF 2701 Avoidance of Utilization of High Ultrafiltration Rate (>/=13 ml/kg/hour) [(accessed on 2 April 2024)]. Available online: https://kidneycarepartners.org/wp-content/uploads/2015/10/Yellow-AllKCQASummary09-11-15CLEAN.pdf.

Mermelstein A., Raimann J.G., Wang Y., Kotanko P., Daugirdas J.T. Ultrafiltration Rate Levels in Hemodialysis Patients Associated with Weight-Specific Mortality Risks. Clin. J. Am. Soc. Nephrol. 2023;18:767–776. doi: 10.2215/CJN.0000000000000144. PubMed DOI PMC

Locatelli F., Altieri P., Andrulli S., Bolasco P., Sau G., Pedrini L.A., Basile C., David S., Feriani M., Montagna G., et al. Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD. J. Am. Soc. Nephrol. 2010;21:1798–1807. doi: 10.1681/ASN.2010030280. PubMed DOI PMC

Donauer J., Schweiger C., Rumberger B., Krumme B., Bohler J. Reduction of hypotensive side effects during online-haemodiafiltration and low temperature haemodialysis. Nephrol. Dial. Transplant. 2003;18:1616–1622. doi: 10.1093/ndt/gfg206. PubMed DOI

Sande F.M.V., Kooman J.P., Konings C.J., Leunissen K.M.L. Thermal effects and blood pressure response during postdilution hemodiafiltration and hemodialysis: The effect of amount of replacement fluid and dialysate temperature. J. Am. Soc. Nephrol. 2001;12:1916–1920. doi: 10.1681/ASN.V1291916. PubMed DOI

Rodriguez A., Morena M., Bargnoux A.S., Chenine L., Leray-Moragues H., Cristol J.P., Canaud B. Quantitative assessment of sodium mass removal using ionic dialysance and sodium gradient as a proxy tool: Comparison of high-flux hemodialysis versus online hemodiafiltration. Artif. Organs. 2021;45:E280–E292. doi: 10.1111/aor.13923. PubMed DOI

Czifra A., Pall A., Kulcsar J., Barta K., Kertesz A., Paragh G., Lorincz I., Jenei Z., Agarwal A., Zarjou A., et al. Hemodialysis and hemodiafiltration differently modulate left ventricular diastolic function. BMC Nephrol. 2013;14:76. doi: 10.1186/1471-2369-14-76. PubMed DOI PMC

La Milia V., Ravasi C., Carfagna F., Alberghini E., Baragetti I., Buzzi L., Ferrario F., Furiani S., Barbone G.S., Pontoriero G. Sodium removal and plasma tonicity balance are not different in hemodialysis and hemodiafiltration using high-flux membranes. J. Nephrol. 2019;32:461–469. doi: 10.1007/s40620-018-00581-z. PubMed DOI

den Hoedt C.H., Bots M.L., Grooteman M.P., van der Weerd N.C., Mazairac A.H., Penne E.L., Levesque R., ter Wee P.M., Nube M.J., Blankestijn P.J., et al. Online hemodiafiltration reduces systemic inflammation compared to low-flux hemodialysis. Kidney Int. 2014;86:423–432. doi: 10.1038/ki.2014.9. PubMed DOI

Maduell F., Moreso F., Pons M., Ramos R., Mora-Macia J., Carreras J., Soler J., Torres F., Campistol J.M., Martinez-Castelao A., et al. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J. Am. Soc. Nephrol. 2013;24:487–497. doi: 10.1681/ASN.2012080875. PubMed DOI PMC

Ok E., Asci G., Toz H., Ok E.S., Kircelli F., Yilmaz M., Hur E., Demirci M.S., Demirci C., Duman S., et al. Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: Results from the Turkish OL-HDF Study. Nephrol. Dial. Transplant. 2013;28:192–202. doi: 10.1093/ndt/gfs407. PubMed DOI

Grooteman M.P., van den Dorpel M.A., Bots M.L., Penne E.L., van der Weerd N.C., Mazairac A.H., den Hoedt C.H., van der Tweel I., Levesque R., Nube M.J., et al. Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes. J. Am. Soc. Nephrol. 2012;23:1087–1096. doi: 10.1681/ASN.2011121140. PubMed DOI PMC

Mercadal L., Franck J.E., Metzger M., Urena Torres P., de Cornelissen F., Edet S., Bechade C., Vigneau C., Drueke T., Jacquelinet C., et al. Hemodiafiltration Versus Hemodialysis and Survival in Patients With ESRD: The French Renal Epidemiology and Information Network (REIN) Registry. Am. J. Kidney Dis. 2016;68:247–255. doi: 10.1053/j.ajkd.2015.11.016. PubMed DOI

Blankestijn P.J., Vernooij R.W.M., Hockham C., Strippoli G.F.M., Canaud B., Hegbrant J., Barth C., Covic A., Cromm K., Cucui A., et al. Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure. N. Engl. J. Med. 2023;389:700–709. doi: 10.1056/NEJMoa2304820. PubMed DOI

Neri L., Gurevich K., Zarya Y., Plavinskii S., Bellocchio F., Stuard S., Barbieri C., Canaud B. Practice Patterns and Outcomes of Online Hemodiafiltration: A Real-World Evidence Study in a Russian Dialysis Network. Blood Purif. 2021;50:309–318. doi: 10.1159/000510551. PubMed DOI

Imamovic G., Hrvacevic R., Kapun S., Marcelli D., Bayh I., Grassmann A., Scatizzi L., Maslovaric J., Canaud B. Survival of incident patients on high-volume online hemodiafiltration compared to low-volume online hemodiafiltration and high-flux hemodialysis. Int. Urol. Nephrol. 2014;46:1191–1200. doi: 10.1007/s11255-013-0526-8. PubMed DOI

Canaud B., Barbieri C., Marcelli D., Bellocchio F., Bowry S., Mari F., Amato C., Gatti E. Optimal convection volume for improving patient outcomes in an international incident dialysis cohort treated with online hemodiafiltration. Kidney Int. 2015;88:1108–1116. doi: 10.1038/ki.2015.139. PubMed DOI PMC

Canaud B., Bayh I., Marcelli D., Ponce P., Merello J.I., Gurevich K., Ladanyi E., Ok E., Imamovic G., Grassmann A., et al. Improved survival of incident patients with high-volume haemodiafiltration: A propensity-matched cohort study with inverse probability of censoring weighting. Nephron. 2015;129:179–188. doi: 10.1159/000371446. PubMed DOI

Maduell F., Varas J., Ramos R., Martin-Malo A., Perez-Garcia R., Berdud I., Moreso F., Canaud B., Stuard S., Gauly A. Hemodiafiltration reduces all-cause and cardiovascular mortality in incident hemodialysis patients: A propensity-matched cohort study. Am. J. Nephrol. 2017;46:288–297. doi: 10.1159/000481669. PubMed DOI

Peters S.A., Bots M.L., Canaud B., Davenport A., Grooteman M.P., Kircelli F., Locatelli F., Maduell F., Morena M., Nubé M.J., et al. Haemodiafiltration and mortality in end-stage kidney disease patients: A pooled individual participant data analysis from four randomized controlled trials. Nephrol. Dial. Transplant. 2016;31:978–984. doi: 10.1093/ndt/gfv349. PubMed DOI

Marcelli D., Scholz C., Ponce P., Sousa T., Kopperschmidt P., Grassmann A., Pinto B., Canaud B. High-volume postdilution hemodiafiltration is a feasible option in routine clinical practice. Artif. Organs. 2015;39:142–149. doi: 10.1111/aor.12345. PubMed DOI PMC

Canaud B., Davenport A. Prescription of online hemodiafiltration (ol-HDF) Semin. Dial. 2022;35:413–419. doi: 10.1111/sdi.13070. PubMed DOI

Sherman R.A., Torres F., Cody R.P. Postprandial blood pressure changes during hemodialysis. Am. J. Kidney Dis. 1988;12:37–39. doi: 10.1016/s0272-6386(88)80069-6. PubMed DOI

Avci M., Arikan F. The effect of food intake during hemodialysis on blood pressure: A nonrandomized experimental trial. Ther. Apher. Dial. 2023;27:661–668. doi: 10.1111/1744-9987.13967. PubMed DOI

Barakat M.M., Nawab Z.M., Yu A.W., Lau A.H., Ing T.S., Daugirdas J.T. Hemodynamic effects of intradialytic food ingestion and the effects of caffeine. J. Am. Soc. Nephrol. 1993;3:1813–1818. doi: 10.1681/asn.V3111813. PubMed DOI

Fotiadou E., Georgianos P.I., Chourdakis M., Zebekakis P.E., Liakopoulos V. Eating during the Hemodialysis Session: A Practice Improving Nutritional Status or a Risk Factor for Intradialytic Hypotension and Reduced Dialysis Adequacy? Nutrients. 2020;12:1703. doi: 10.3390/nu12061703. PubMed DOI PMC

Kalantar-Zadeh K., Ikizler T.A. Let them eat during dialysis: An overlooked opportunity to improve outcomes in maintenance hemodialysis patients. J. Ren. Nutr. 2013;23:157–163. doi: 10.1053/j.jrn.2012.11.001. PubMed DOI PMC

Bansal N., McCulloch C.E., Lin F., Alper A., Anderson A.H., Cuevas M., Go A.S., Kallem R., Kusek J.W., Lora C.M., et al. Blood Pressure and Risk of Cardiovascular Events in Patients on Chronic Hemodialysis: The CRIC Study (Chronic Renal Insufficiency Cohort) Hypertension. 2017;70:435–443. doi: 10.1161/hypertensionaha.117.09091. PubMed DOI PMC

Hara M., Tanaka S., Taniguchi M., Fujisaki K., Torisu K., Masutani K., Hirakata H., Nakano T., Tsuruya K., Kitazono T. Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients: The Q-Cohort Study. Medicine. 2018;97:e13485. doi: 10.1097/md.0000000000013485. PubMed DOI PMC

Bansal N., McCulloch C.E., Rahman M., Kusek J.W., Anderson A.H., Xie D., Townsend R.R., Lora C.M., Wright J., Go A.S., et al. Blood pressure and risk of all-cause mortality in advanced chronic kidney disease and hemodialysis: The chronic renal insufficiency cohort study. Hypertension. 2015;65:93–100. doi: 10.1161/hypertensionaha.114.04334. PubMed DOI PMC

Robinson B.M., Tong L., Zhang J., Wolfe R.A., Goodkin D.A., Greenwood R.N., Kerr P.G., Morgenstern H., Li Y., Pisoni R.L., et al. Blood pressure levels and mortality risk among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2012;82:570–580. doi: 10.1038/ki.2012.136. PubMed DOI PMC

Liang Y., Gan L., Shen Y., Li W., Zhang D., Li Z., Ren J., Xu M., Zhao X., Ma Y., et al. Clinical characteristics and management of hemodialysis patients with pre-dialysis hypertension: A multicenter observational study. Ren. Fail. 2022;44:1811–1818. doi: 10.1080/0886022X.2022.2136527. PubMed DOI PMC

Wang K.M., Sirich T.L., Chang T.I. Timing of blood pressure medications and intradialytic hypotension. Semin. Dial. 2019;32:201–204. doi: 10.1111/sdi.12777. PubMed DOI PMC

Hemodialysis Adequacy Work Group Clinical practice guidelines for hemodialysis adequacy, update 2006. Am. J. Kidney Dis. 2006;48((Suppl. S1)):S2–S90. doi: 10.1053/j.ajkd.2006.03.051. PubMed DOI

Gregory L.F., Jr., Durrett R.R., Robinson R.R., Clapp J.R. The short-term effect of furosemide on electrolyte and water excretion in patients with severe renal disease. Arch. Intern. Med. 1970;125:69–74. doi: 10.1001/archinte.1970.00310010071005. PubMed DOI

Levin N.W., Kotanko P., Eckardt K.U., Kasiske B.L., Chazot C., Cheung A.K., Redon J., Wheeler D.C., Zoccali C., London G.M. Blood pressure in chronic kidney disease stage 5D-report from a Kidney Disease: Improving Global Outcomes controversies conference. Kidney Int. 2010;77:273–284. doi: 10.1038/ki.2009.469. PubMed DOI

Jindal K., Chan C.T., Deziel C., Hirsch D., Soroka S.D., Tonelli M., Culleton B.F., Canadian Society of Nephrology Committee for Clinical Practice Guidelines Hemodialysis clinical practice guidelines for the Canadian Society of Nephrology. J. Am. Soc. Nephrol. 2006;17:S1–S27. doi: 10.1681/ASN.2005121372. PubMed DOI