Kinetochore and ionomic adaptation to whole-genome duplication in Cochlearia shows evolutionary convergence in three autopolyploids
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
39116207
DOI
10.1016/j.celrep.2024.114576
PII: S2211-1247(24)00905-7
Knihovny.cz E-resources
- Keywords
- CP: Genomics, CP: Plants, evolution, ion homeostasis, kinetochore, meiosis, polyploidy,
- MeSH
- Gene Duplication MeSH
- Adaptation, Physiological genetics MeSH
- Genome, Plant * MeSH
- Kinetochores * metabolism MeSH
- Meiosis genetics MeSH
- Evolution, Molecular * MeSH
- Polyploidy * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Whole-genome duplication (WGD) occurs in all kingdoms and impacts speciation, domestication, and cancer outcome. However, doubled DNA management can be challenging for nascent polyploids. The study of within-species polyploidy (autopolyploidy) permits focus on this DNA management aspect, decoupling it from the confounding effects of hybridization (in allopolyploid hybrids). How is autopolyploidy tolerated, and how do young polyploids stabilize? Here, we introduce a powerful model to address this: the genus Cochlearia, which has experienced many polyploidization events. We assess meiosis and other polyploid-relevant phenotypes, generate a chromosome-scale genome, and sequence 113 individuals from 33 ploidy-contrasting populations. We detect an obvious autopolyploidy-associated selection signal at kinetochore components and ion transporters. Modeling the selected alleles, we detail evidence of the kinetochore complex mediating adaptation to polyploidy. We compare candidates in independent autopolyploids across three genera separated by 40 million years, highlighting a common function at the process and gene levels, indicating evolutionary flexibility in response to polyploidy.
Central European Institute of Technology Masaryk University 625 00 Brno Czech Republic
Centre for Organismal Studies Heidelberg University 69120 Heidelberg Germany
Department of Crop Genetics John Innes Centre Norwich Research Park Norwich NR4 7UH UK
Department of Genetics and Genome Biology University of Leicester Leicester LE1 7RH UK
The John Innes Centre Norwich NR4 7UH UK
The University of Nottingham Nottingham NG7 2RD UK
The University of Nottingham Nottingham NG7 2RD UK; The John Innes Centre Norwich NR4 7UH UK
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