Kinetochore and ionomic adaptation to whole-genome duplication in Cochlearia shows evolutionary convergence in three autopolyploids
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
39116207
DOI
10.1016/j.celrep.2024.114576
PII: S2211-1247(24)00905-7
Knihovny.cz E-zdroje
- Klíčová slova
- CP: Genomics, CP: Plants, evolution, ion homeostasis, kinetochore, meiosis, polyploidy,
- MeSH
- duplikace genu MeSH
- fyziologická adaptace genetika MeSH
- genom rostlinný * MeSH
- kinetochory * metabolismus MeSH
- meióza genetika MeSH
- molekulární evoluce * MeSH
- polyploidie * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Whole-genome duplication (WGD) occurs in all kingdoms and impacts speciation, domestication, and cancer outcome. However, doubled DNA management can be challenging for nascent polyploids. The study of within-species polyploidy (autopolyploidy) permits focus on this DNA management aspect, decoupling it from the confounding effects of hybridization (in allopolyploid hybrids). How is autopolyploidy tolerated, and how do young polyploids stabilize? Here, we introduce a powerful model to address this: the genus Cochlearia, which has experienced many polyploidization events. We assess meiosis and other polyploid-relevant phenotypes, generate a chromosome-scale genome, and sequence 113 individuals from 33 ploidy-contrasting populations. We detect an obvious autopolyploidy-associated selection signal at kinetochore components and ion transporters. Modeling the selected alleles, we detail evidence of the kinetochore complex mediating adaptation to polyploidy. We compare candidates in independent autopolyploids across three genera separated by 40 million years, highlighting a common function at the process and gene levels, indicating evolutionary flexibility in response to polyploidy.
Central European Institute of Technology Masaryk University 625 00 Brno Czech Republic
Centre for Organismal Studies Heidelberg University 69120 Heidelberg Germany
Department of Crop Genetics John Innes Centre Norwich Research Park Norwich NR4 7UH UK
Department of Genetics and Genome Biology University of Leicester Leicester LE1 7RH UK
The John Innes Centre Norwich NR4 7UH UK
The University of Nottingham Nottingham NG7 2RD UK
The University of Nottingham Nottingham NG7 2RD UK; The John Innes Centre Norwich NR4 7UH UK
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