Different behavior of food-related benzoic acids toward iron and copper
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
39226645
DOI
10.1016/j.foodchem.2024.141014
PII: S0308-8146(24)02664-5
Knihovny.cz E-zdroje
- Klíčová slova
- Antioxidant, Chelation, Fenton reaction, Hemolysis, Hydroxyl radical, Pro-oxidant, Reduction,
- MeSH
- benzoáty * chemie MeSH
- chelátory chemie farmakologie MeSH
- erytrocyty * účinky léků chemie metabolismus MeSH
- hemolýza účinky léků MeSH
- krysa rodu Rattus MeSH
- lidé MeSH
- měď * chemie MeSH
- železo * chemie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- benzoáty * MeSH
- chelátory MeSH
- měď * MeSH
- železo * MeSH
Benzoic acids, which are commonly found in food, are also produced by human microbiota from other dietary phenolics. The aim was to investigate the interactions of 8 food-related benzoic acids with the physiological metals iron and copper under different (patho)physiologically relevant pH conditions in terms of chelation, reduction, impact on the metal-based Fenton chemistry, and copper-based hemolysis. Only 3,4-dihydroxybenzoic acid behaved as a protective substance under all conditions. It chelated iron, reduced both iron and copper, and protected against the iron and copper-based Fenton reaction. Conversely, 2,4,6-trihydroxybenzoic acid did not chelate iron and copper, reduced both metals, potentiated the Fenton reaction, and worsened copper-based hemolysis of rat red blood cells. The other tested compounds showed variable effects on the Fenton reaction. Interestingly, prooxidative benzoic acids mildly protected human erythrocytes against Cu-induced lysis. In conclusion, 3,4-dihydroxybenzoic acid seems to have a protective effect against copper and iron-based toxicity under different conditions.
Citace poskytuje Crossref.org
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