Mitochondrial DNA damage, repair, and replacement in cancer
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
39438191
DOI
10.1016/j.trecan.2024.09.010
PII: S2405-8033(24)00212-7
Knihovny.cz E-resources
- Keywords
- DNA stability, base excision repair, cancer, horizontal mitochondrial transfer, mitochondrial DNA, mitochondrial DNA damage repair, nuclear DNA,
- MeSH
- Humans MeSH
- DNA, Mitochondrial * genetics metabolism MeSH
- Mitochondria * genetics pathology metabolism MeSH
- Neoplasms * genetics pathology MeSH
- DNA Repair * MeSH
- DNA Damage * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- DNA, Mitochondrial * MeSH
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are structurally more accessible than nuclear DNA (nDNA). While nDNA is typically diploid, the number of mtDNA copies per cell is higher and varies considerably during development and between tissues. Compared with nDNA, mtDNA is more prone to damage that is positively linked to many diseases, including cancer. Similar to nDNA, mtDNA undergoes repair processes, although these mechanisms are less well understood. In this review, we discuss the various forms of mtDNA damage and repair and their association with cancer initiation and progression. We also propose horizontal mitochondrial transfer as a novel mechanism for replacing damaged mtDNA.
Institute of Biotechnology Czech Academy of Sciences 252 50 Prague West Czech Republic
Malaghan Institute of Medical Research Wellington 6242 New Zealand
References provided by Crossref.org
