Is KIBRA polymorphism associated with memory performance and cognitive impairment in Alzheimer's disease?
Language English Country United States Media print-electronic
Document type Journal Article
- Keywords
- Alzheimer's disease, ApoE, BDNF, KIBRA, cognitive impairments, memory,
- MeSH
- Alleles MeSH
- Alzheimer Disease * genetics MeSH
- Apolipoprotein E4 genetics MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genotype MeSH
- Intracellular Signaling Peptides and Proteins genetics MeSH
- Polymorphism, Single Nucleotide * genetics MeSH
- Cognitive Dysfunction * genetics MeSH
- Humans MeSH
- Brain-Derived Neurotrophic Factor genetics MeSH
- Neuropsychological Tests MeSH
- Memory physiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Apolipoprotein E4 MeSH
- Intracellular Signaling Peptides and Proteins MeSH
- Brain-Derived Neurotrophic Factor MeSH
- WWC1 protein, human MeSH Browser
BACKGROUND: Genetic variations in a common single nucleotide polymorphism in the ninth intron of the KIBRA gene have been linked to memory performance and risk of Alzheimer's disease (AD). OBJECTIVE: We examined the risk of AD related to presence of KIBRA T allele (versus CC homozygote) and to memory performance. The role of established genetic risk factors APOE ε4 and BDNF Met was also considered. METHODS: Participants were cognitively healthy individuals (n = 19), participants with amnestic mild cognitive impairment (aMCI) due to AD (n = 99) and AD dementia (n = 37) from the Czech Brain Aging Study. Binary and multinomial logistic regressions compared odds of belonging to a certain diagnostic category and multivariate linear regressions assessed associations with memory. RESULTS: KIBRA T allele was associated with increased AD dementia risk (odds ratio [OR] = 5.98, p = 0.012) compared to KIBRA CC genotype. In APOE ε4 negative individuals, KIBRA T allele was associated with a greater risk of both aMCI due to AD (OR = 6.68, p = 0.038) and AD dementia (OR = 15.75, p = 0.009). In BDNF Met positive individuals, the KIBRA T allele was associated with a greater risk of AD dementia (OR = 10.98, p = 0.050). In AD dementia, the association between KIBRA T allele and better memory performance approached significance (β = 0.42; p = 0.062). The link between possessing the KIBRA T allele and better memory reached statistical significance only among BDNF Met carriers (β = 1.21, p = 0.027). CONCLUSIONS: Findings suggest that KIBRA T allele may not fully protect against AD dementia but could potentially delay progression of post-diagnosis cognitive deficits.
Department of Clinical Biochemistry Hematology and Immunology Homolka Hospital Prague Czech Republic
Edson College of Nursing and Health Innovation Arizona State University Phoenix AZ USA
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
References provided by Crossref.org
