Breast cancer is a prevalent and aggressive disease characterized by high metastasis, recurrence, and mortality rates. While cisplatin is an effective chemotherapy drug, its use is limited by its toxic effects on the body. Despite advancements in therapeutic strategies, the therapeutic response is often unsatisfactory due to drug resistance, leading to poor prognosis. Recent studies have shown that cisplatin interacts with long non-coding RNAs (lncRNAs) and accelerates the development of resistance in tumor cells to therapy. This interaction highlights the complex mechanisms involved in the response of cancer cells to chemotherapy. Several lncRNAs have been identified as key players in mediating cisplatin resistance in breast cancer. These lncRNAs include SNHG15, HULC, HCP5, MT1JP, LncMat2B, DLX6-ASL, Linc00665, CARMN, and Lnc-EinRP44-3:6. These lncRNAs have been shown to target microRNAs and mRNAs and modulate the expression of genes involved in cisplatin resistance, which is important in treating breast cancer.

Atherosclerosis Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of Human Morphology and Embryology Division of Anatomy Wroclaw Medical University Wroclaw Poland

Department of Human Morphology and Embryology Division of Anatomy Wroclaw Medical University Wroclaw Poland; Department of Toxicology Poznan University of Medical Sciences Poznan Poland

Department of Human Morphology and Embryology Division of Anatomy Wroclaw Medical University Wroclaw Poland; Graduate Physiology Program North Carolina State University Raleigh NC 27695 USA; Department of Veterinary Surgery Institute of Veterinary Medicine Nicolaus Copernicus University Torun Poland; Center of Assisted Reproduction Department of Obstetrics and Gynecology University Hospital and Masaryk University Brno Czech Republic

Department of Human Morphology and Embryology Division of Histology and Embryology Wroclaw Medical University Wroclaw Poland; Department of Human Biology Faculty of Physiotherapy Wroclaw University of Health and Sport Sciences Wroclaw Poland

Department of Laboratory Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran

Department of Obstetrics and Gynecology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Fertility Infertility and Perinatology Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran; Clinical Research Development Unit Imam Khomeini Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran; Cancer Environmental and Petroleum Pollutants Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Graduate Physiology Program North Carolina State University Raleigh NC 27695 USA; Prestage Department of Poultry Science North Carolina State University Raleigh NC 27695 USA

Citace poskytuje Crossref.org