LncRNA-mediated regulation of cisplatin response in breast cancer
Language English Country Germany Media print-electronic
Document type Journal Article, Review
PubMed
39536542
DOI
10.1016/j.prp.2024.155716
PII: S0344-0338(24)00627-7
Knihovny.cz E-resources
- Keywords
- Breast cancer, Cisplatin, Long non-coding RNAs, Resistance,
- MeSH
- Drug Resistance, Neoplasm * genetics MeSH
- Cisplatin * therapeutic use pharmacology MeSH
- Humans MeSH
- Breast Neoplasms * drug therapy genetics pathology metabolism MeSH
- Antineoplastic Agents * therapeutic use pharmacology MeSH
- Gene Expression Regulation, Neoplastic * drug effects MeSH
- RNA, Long Noncoding * genetics metabolism MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Cisplatin * MeSH
- Antineoplastic Agents * MeSH
- RNA, Long Noncoding * MeSH
Breast cancer is a prevalent and aggressive disease characterized by high metastasis, recurrence, and mortality rates. While cisplatin is an effective chemotherapy drug, its use is limited by its toxic effects on the body. Despite advancements in therapeutic strategies, the therapeutic response is often unsatisfactory due to drug resistance, leading to poor prognosis. Recent studies have shown that cisplatin interacts with long non-coding RNAs (lncRNAs) and accelerates the development of resistance in tumor cells to therapy. This interaction highlights the complex mechanisms involved in the response of cancer cells to chemotherapy. Several lncRNAs have been identified as key players in mediating cisplatin resistance in breast cancer. These lncRNAs include SNHG15, HULC, HCP5, MT1JP, LncMat2B, DLX6-ASL, Linc00665, CARMN, and Lnc-EinRP44-3:6. These lncRNAs have been shown to target microRNAs and mRNAs and modulate the expression of genes involved in cisplatin resistance, which is important in treating breast cancer.
References provided by Crossref.org
