Acute polyneuropathy: a serious complication of levodopa/ /carbidopa intestinal gel treatment for Parkinson's Disease
Language English Country Poland Media print-electronic
Document type Journal Article, Multicenter Study
PubMed
39564873
DOI
10.5603/pjnns.100132
PII: VM/OJS/J/100132
Knihovny.cz E-resources
- Keywords
- Parkinson’s Disease, acute polyneuropathy, levodopa equivalent daily dose, levodopa/carbidopa intestinal gel,
- MeSH
- Antiparkinson Agents * adverse effects administration & dosage MeSH
- Drug Combinations * MeSH
- Gels * MeSH
- Carbidopa * administration & dosage adverse effects MeSH
- Levodopa * administration & dosage adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Parkinson Disease * drug therapy MeSH
- Polyneuropathies * chemically induced drug therapy MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Names of Substances
- Antiparkinson Agents * MeSH
- carbidopa, levodopa drug combination MeSH Browser
- Drug Combinations * MeSH
- Gels * MeSH
- Carbidopa * MeSH
- Levodopa * MeSH
AIM OF STUDY: To determine whether a high dose of levodopa-carbidopa intestinal gel (LCIG), expressed as levodopa equivalent daily dose (LE daily dose), is a risk factor for acute polyneuropathy in patients treated with LCIG. CLINICAL RATIONALE FOR STUDY: Treatment with LCIG is an effective device-assisted therapy in the advanced stages of Parkinson's Disease (PD). Polyneuropathy is a well-known complication of PD treatment. Patients treated with oral levodopa usually suffer from sub-clinical or mild chronic sensory polyneuropathy. However, severe acute polyneuropathy occurs in patients treated with LCIG, which is causally related to the treatment and leads to its immediate discontinuation. The etiology is not yet clear, but some patients with acute polyneuropathy have been given high doses of LCIG. MATERIAL AND METHODS: A retrospective multicentre study of patients treated with LCIG was performed. Patients with acute polyneuropathy were subjected to a detailed analysis including statistical processing. RESULTS: Of 183 patients treated with LCIG in seven centres, six patients (five females, median age 63 years) developed acute polyneuropathy with LCIG discontinuation. The median (interquartile range) initial and final LE daily dose in patients with and without acute polyneuropathy was 3,015 (2,695-3,184) and 1,898 (1,484-2,167) mg, respectively. The final LE daily dose of 2,605 mg cut-off had 83% sensitivity and 93% specificity for the prediction of acute polyneuropathy. CONCLUSIONS AND CLINICAL IMPLICATIONS: The risk of acute polyneuropathy in LCIG-treated patients was associated with a daily LE dose of greater than 2,605 mg or with more than a 62% increase in the daily LE dose during LCIG treatment.
2nd Department of Neurology Faculty of Medicine Comenius University Bratislava Slovakia
2nd Department of Neurology Faculty of Medicine Comenius University in Bratislava Slovakia
Department of Neurology Faculty of Medicine Pavol Jozef Safarik University Kosice Slovakia
Department of Neurology University Hospital of Louis Pasteur Kosice Slovakia
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