The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline proposes the nomenclature Bone Status Indices (BSI) as the comprehensive classification rather than bone turnover markers, bone markers, metabolic markers of bone turnover or metabolic markers of bone turnover, that are currently in use for the implicated molecules. On behalf of the IFCC Committee on Bone Metabolism and the Joint IOF Working Group and IFCC Committee on Bone Metabolism, the authors propose standardized nomenclature, abbreviations and measurement units for the bone status indices.

Cedars Sinai Medical Center and Geffen School of Medicine UCLA Los Angeles CA USA

Centre for Metabolic Bone Diseases University of Sheffield Sheffield UK

Clinical Biochemistry Department KAT General Hospital Kifissia Athens Greece

Department of Athletics Strength and Conditioning Poznań University of Physical Education Poznań Poland

Department of Clinical Biochemistry and Bone Metabolism Klatovska Hospital Klatovy Czech Republic

Department of Clinical Biochemistry and Haematology Faculty of Medicine Pilsen Charles University Prague Pilsen Czech Republic

Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark

Department of Clinical Chemistry CIRM University of Liège CHU de Liège Belgium

Department of Clinical Sciences Clinical and Molecular Osteoporosis Research Unit Lund University Malmö Sweden

Department of Laboratory Medicine Faculty of Medicine University of Debrecen Debrecen Hungary

Department of Medicine Division of Rheumatology U C Davis Health Sacramento CA USA

Department of Orthopaedics Skåne University Hospital Malmö Sweden

Division of Clinical Medicine School of Medicine and Population Health University of Sheffield Sheffield UK

Faculty of Health and Medical Sciences Institute of Clinical Medicine University of Copenhagen Copenhagen Denmark

Faculty of Health Care Studies University of West Bohemia Pilsen Czech Republic

INSERM Unit 1033 Edouard Herriot Hospital Lyon France

International Institute for Biosensing University of Minnesota Minneapolis USA

Laboratory for the Research of Musculoskeletal System Th Garofalidis School of Medicine National and Kapodistrian University of Athens Athens Greece

Laboratory of Experimental Biochemistry IRCCS Ospedale Galeazzi Sant'Ambrogio Milan Italy

Mary McKillop Institute for Health Research Australian Catholic University Melbourne Australia

Mellanby Centre for Musculoskeletal Research MRC Versus Arthritis Centre for Integrated Research in Musculoskeletal Ageing University of Sheffield Sheffield UK

MRC Lifecourse Epidemiology Centre University of Southampton Southampton UK

NIHR Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK

Oregon Osteoporosis Center Portland OR USA

PathWest Laboratory Medicine Fiona Stanley Hospital Murdoch WA Australia

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Standardization of the nomenclature of bone status indices: a milestone in diagnostic consistency and clarity