The first appearance of the zoonotic parasite Cryptosporidium mortiferum in human and tree and ground squirrels in Central Europe
Language English Country United States Media print-electronic
Document type Journal Article, Case Reports
PubMed
39825473
PubMed Central
PMC11789217
DOI
10.1080/22221751.2025.2456148
Knihovny.cz E-resources
- Keywords
- Cryptosporidium mortiferum, human, infection, squirrels,
- MeSH
- Cryptosporidium * genetics isolation & purification classification MeSH
- Adult MeSH
- Feces parasitology MeSH
- Phylogeny MeSH
- Gastroenteritis parasitology MeSH
- Cryptosporidiosis * parasitology transmission epidemiology diagnosis MeSH
- Humans MeSH
- Sciuridae * parasitology MeSH
- Disease Reservoirs parasitology MeSH
- Zoonoses * parasitology transmission MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Geographicals
- Czech Republic MeSH
- Europe MeSH
Cryptosporidium mortiferum, a parasite transmitted by squirrels, is beginning to spread in Europe. C. mortiferum was detected in a symptomatic human. A 44-year-old man from the Czech Republic suffered from gastroenteritis characterized by abdominal pain, nausea, and loose stools. Molecular analyses confirmed the XIVaA20G2T1 subtype in the patient's stool. At the same time, the same subtype of C. mortiferum was detected in three red squirrels and two ground squirrels in the area where the patient lived. The intensity of the infection was significantly higher in the red squirrels that died, while the ground squirrels showed no symptoms. The results of the study indicate that red squirrels and ground squirrels are the reservoirs for the infection.
Czech Union of Nature Conservationists Animal Rescue Center Vlašim Czech Republic
Department of Biology and Medical Parasitology Wroclaw Medical University Wroclaw Poland
Department of Microbiological Sciences North Dakota State University Fargo ND USA
Faculty of Agriculture and Technology University of South Bohemia České Budějovice Czech Republic
See more in PubMed
Nader JL, Mathers TC, Ward BJ, et al. . Evolutionary genomics of anthroponosis in Cryptosporidium. Nat Microbiol. 2019;4:826–36. PubMed
Jiang J, Alderisio KA, Xiao L.. Distribution of Cryptosporidium genotypes in storm event water samples from three watersheds in New York. Appl Environ Microbiol. 2005;71:4446–54. PubMed PMC
Lebbad M, Beser J, Insulander M, et al. . Unusual cryptosporidiosis cases in Swedish patients: extended molecular characterization of Cryptosporidium viatorum and Cryptosporidium chipmunk genotype I. Parasitology. 2013;140:1735–40. PubMed
Stenger BL, Clark ME, Kváč M, et al. . North American tree squirrels and ground squirrels with overlapping ranges host different Cryptosporidium species and genotypes. Infect Genet Evol. 2015;36:287–93. PubMed
Stensvold CR, Larsen TG, Grüttner J, et al. . Rodent-adapted infection in humans: Seven new cases and review of the literature. One Health. 2024;18:100682. PubMed PMC
Häkkänen T, Rimhanen-Finne R, Antikainen J, et al. . Molecular characteristics of spp. in human cases in five Finnish hospital districts during 2021: first findings of chipmunk genotype I) in Finland. Int J Parasitol. 2024;54:225–31. PubMed
Prediger J, Horčičková M, Hofmannová L, et al. . Native and introduced squirrels in Italy host different Cryptosporidium spp. Eur J Protistol. 2017;61:64–75. PubMed
Kváč M, Hofmannová L, Bertolino S, et al. . Natural infection with two genotypes of Cryptosporidium in red squirrels (Sciurus vulgaris) in Italy. Folia Parasitol. 2008;55:95–9. PubMed
Henriksen SA, Pohlenz JF.. Staining of cryptosporidia by a modified Ziehl-Neelsen technique. Acta Vet Scand. 1981;22:594–6. PubMed PMC
Sak B, Kváč M, Hanzlíková D, et al. . First report of Enterocytozoon bieneusi infection on a pig farm in the Czech Republic. Vet Parasitol. 2008;153:220–4. PubMed
Guo Y, Cebelinski E, Matusevich C, et al. . Subtyping novel zoonotic pathogen Cryptosporidium chipmunk genotype I. J Clin Microbiol. 2015;53:1648–54. PubMed PMC
Tůmová L, Ježková J, Prediger J, et al. . Cryptosporidium mortiferum n. sp. (Apicomplexa: Cryptosporidiidae), the species causing lethal cryptosporidiosis in Eurasian red squirrels (Sciurus vulgaris). Parasit Vectors. 2023;16:235. PubMed PMC
Prediger J, Ježková J, Holubová N, et al. . Cryptosporidium sciurinum n. sp. (Apicomplexa: Cryptosporidiidae) in Eurasian Red Squirrels (Sciurus vulgaris). Microorganisms. 2021;9:2050. PubMed PMC
Bujila I, Troell K, Fischerstrom K, et al. . Cryptosporidium chipmunk genotype I – An emerging cause of human cryptosporidiosis in Sweden. Infect Genet Evol. 2021;92:104895. PubMed