Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes. An active chloride transporter was obtained in situ within the lipid bilayer by dynamic azine metathesis. The transport activity was further tuned by changing the structure of the added azines, while the dynamic covalent chemistry could be activated by lowering the pH. This dynamic covalent chemistry opens a new approach towards controlling transmembrane transport.

Department of Chemistry and RECETOX Faculty of Science Masaryk University Brno 62500 Czech Republic

Engineering of Molecular NanoSystems Université libre de Bruxelles Avenue F D Roosevelt 50 CP165 64 B 1050 Brussels Belgium

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