The Rare Gynecologic Sarcoma Study: Molecular and Clinicopathologic Results of A Project on 379 Uterine Sarcomas
Status Publisher Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
39921027
DOI
10.1016/j.labinv.2025.104092
PII: S0023-6837(25)00002-9
Knihovny.cz E-zdroje
- Klíčová slova
- endometrial stromal sarcoma, next-generation sequencing, undifferentiated uterine sarcoma, uterine tumor,
- Publikační typ
- časopisecké články MeSH
The Rare Gynecologic Sarcoma study involved 23 institutions from 10 countries focusing on myxoid leiomyosarcoma and non-smooth muscle uterine sarcomas. Here, we present the main results of the study, including the comparison between the original and final diagnosis, the frequency and type of molecular aberrations, and the clinicopathologic outcomes. A total of 379 cases were included, with available results for next-generation sequencing (NGS) RNA in 338 of 379 cases and NGS DNA in 335 of 379 cases. According to the original diagnoses, the study included 204 cases of low-grade endometrial stromal sarcoma (LG-ESS), 75 cases of high-grade endometrial stromal sarcoma (HG-ESS), 74 cases of undifferentiated uterine sarcoma (UUS), 17 cases of myxoid leiomyosarcoma, and 9 cases of unclassifiable sarcoma. The results of our second reading showed that 29% (110/379) of all the tumors had been originally misdiagnosed. After the reclassification, the final diagnoses were 147 cases of LG-ESS, 69 cases of HG-ESS, 58 cases of UUS, 3 cases of LG-ESS with high-grade transformation, 7 cases of perivascular epithelioid cell tumor, 9 cases of uterine tumor resembling ovarian sex cord tumor, 8 cases of tumors with a KAT6B/A::KANSL1 fusion, 2 cases of tumors with an NTRK fusion, 29 cases of undifferentiated carcinoma, and 47 tumors with smooth muscle differentiation. The molecular testing showed that LG-ESS harbor a recurrent fusion in 75.9% and HG-ESS in 43.7% of cases. The results of our study emphasize the diagnostic, prognostic, and predictive significance of molecular testing in mesenchymal uterine tumors.
1st Department of Gynecologic Oncology and Gynecology Medical University of Lublin Lublin Poland
Caucasus Medical Center Tbilisi Georgia
Danylo Halytsky Lviv National Medical University Lviv Ukraine
Department of Gynecologic Oncology Khmelnytskyi Regional Antitumor Center Khmelnytskyi Citi Ukraine
Department of Gynecologic Oncology Pomeranian Hospitals Gdynia Oncology Center Gdynia Poland
Department of Gynecology and Obstetrics Bata Regional Hospital in Zlin Zlin Czech Republic
Department of Obstetrics and Gynecology University of Debrecen Debrecen Hungary
Department of Pathology National Oncology Institute Bratislava Slovakia
Department of Pathology University Hospital Bulovka Prague Czech Republic
Gynecologic Oncology Unit La Paz University Hospital Madrid Spain
Pathology Department La Paz University Hospital Madrid Spain
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