Can the Contents of Biogenic Amines in Olomoucké Tvarůžky Cheeses Be Risky for Consumers?

. 2025 Jan 31 ; 14 (3) : . [epub] 20250131

Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid39942049

Grantová podpora
GAJU 005/2022/Z University of South Bohemia České Budějovice

Smear-ripened cheeses are fermented dairy products characterised by an increased content of biogenic amines (BAs). The high contents of these bioactive compounds can negatively affect consumers. The study aimed to observe the contents of BAs and po-lyamines (PAs) in Olomoucké tvarůžky cheeses depending on selected factors (year, batch, ripening/storage time, shape, weight, specific surface area, acidity, and salt content). The results showed that the variability was explained primarily by the batch (83% for the sum of BAs) and by the year (63% for the sum of PAs). The storage time significantly influenced the contents of putrescine, cadaverine, spermidine, and spermine (the explained variability was only 1-3%). The total BA contents negatively correlated with weight (r = -0.6374; p < 0.001) and positively with specific surface area (r = +0.4349; p < 0.001). A negligible positive correlation coefficient was found between the total BAs and pH (r = +0.1303). A low negative correlation was also found between the total BAs and salt content (r = -0.1328). Compared to previous studies, the total average BA contents were considerably low. In conclusion, this type of cheese does not represent a serious problem for most consumers.

Zobrazit více v PubMed

Feddern V., Mazzuco H., Fonseca F.N., de Lima G.J.M.M. A review on biogenic amines in food and feed: Toxicological aspects, impact on health and control measures. Anim. Prod. Sci. 2019;59:608–618. doi: 10.1071/AN18076. DOI

Kalač P. Health effects and occurrence of dietary polyamines: A review for the period 2005-mid 2013. Food Chem. 2014;161:27–39. doi: 10.1016/j.foodchem.2014.03.102. PubMed DOI

Ruiz-Capillas C., Herrero A.M. Impact of biogenic amines on food quality and safety. Foods. 2019;8:62. doi: 10.3390/foods8020062. PubMed DOI PMC

Moschou P.N., Wu J., Cona A., Tavladoraki P., Angelini R., Roubelakis-Angelakis K.A. The polyamines and their catabolic products are significant players in the turnover of nitrogenous molecules in plants. J. Exp. Bot. 2012;63:5003–5015. doi: 10.1093/jxb/ers202. PubMed DOI

Bardócz S. Polyamines in food and their consequences for food quality and human health. Trends Food Sci. Tech. 1995;6:341–346. doi: 10.1016/S0924-2244(00)89169-4. DOI

Lenis Y.Y., Elmetwally M.A., Maldonado-Estrada J.G., Bazer F.W. Physiological importance of polyamines. Zygote. 2017;25:244–255. doi: 10.1017/S0967199417000120. PubMed DOI

Sarkadi L.S. Amino acids and biogenic amines as food quality factors. Pure Appl. Chem. 2019;91:289–300. doi: 10.1515/pac-2018-0709. DOI

Schirone M., Visciano P., Conte F., Paparella A. Formation of biogenic amines in the cheese production chain: Favouring and hindering factors. Int. Dairy. J. 2022;133:105420. doi: 10.1016/j.idairyj.2022.105420. DOI

Natrella G., Vacca M., Minervini F., Faccia M., De Angelis M. A comprehensive review on the biogenic amines in cheeses: Their origin, chemical characteristics, hazard and reduction strategies. Foods. 2024;13:2583. doi: 10.3390/foods13162583. PubMed DOI PMC

Shalaby A.R. Significance of biogenic amines to food safety and human health. Food Res. Int. 1996;29:675–690. doi: 10.1016/S0963-9969(96)00066-X. DOI

del Rio B., Fernandez M., Redruello B., Ladero V., Alvarez M.A. New insights into the toxicological effects of dietary biogenic amines. Food Chem. 2024;435:137558. doi: 10.1016/j.foodchem.2023.137558. PubMed DOI

Kalač P., Glória M.B.A. Biogenic amines in cheeses, wines, beers and sauerkraunt. In: Dandrifosse G., editor. Biological Aspects of Biogenic Amines, Polyamines and Conjugates. Transworld Research Network; Trivandrum, India: 2009. pp. 267–309.

Samková E., Dadáková E., Pelikánová T. Changes in biogenic amine and polyamine contents in smear-ripened cheeses during storage. Eur. Food Res. Technol. 2013;237:309–314. doi: 10.1007/s00217-013-1993-y. DOI

Standarová E., Borkovcová I., Dušková M., Přidalová H., Dračková M., Vorlová L. Effect of some factors on the biogenic amines and polyamines content in blue-veined cheese Niva. Czech J. Food Sci. 2009;27:S410–S413. doi: 10.17221/965-CJFS. DOI

Standarová E., Vorlová L., Kordiovská P., Janštová B., Dračková M., Borkovcová I. Biogenic amine production in Olomouc curd cheese (Olomoucke tvaruzky) at various storage conditions. Acta Vet. Brno. 2010;79:147–156. doi: 10.2754/avb201079010147. DOI

Ferroukhi I., Chassard C., Mardon J. A comprehensive overview of blue-veined cheeses. Int. Dairy. J. 2024;154:105926. doi: 10.1016/j.idairyj.2024.105926. DOI

Mayer H.K., Fiechter G. UHPLC analysis of biogenic amines in different cheese varieties. Food Control. 2018;93:9–16. doi: 10.1016/j.foodcont.2018.05.040. DOI

Pleva P., Buňková L., Theimrová E., Bartošáková V., Buňka F., Purevdorj K. Biogenic amines in smear and mould-ripened cheeses. Potravinarstvo Slovak J. Food Sci. 2014;8:321–327. doi: 10.5219/408. DOI

Zdolec N., Bogdanović T., Severin K., Dobranić V., Kazazić S., Grbavac J., Pleadin J., Petričević S., Kiš M. Biogenic amine content in retailed cheese varieties produced with commercial bacterial or mold cultures. Processes. 2022;10:10. doi: 10.3390/pr10010010. DOI

Jaguey-Hernández Y., Aguilar-Arteaga K., Ojeda-Ramirez D., Añorve-Morga J., González-Olivares L.G., Castañeda-Ovando A. Biogenic amines levels in food processing: Efforts for their control in foodstuffs. Food Res. Int. 2021;144:110341. doi: 10.1016/j.foodres.2021.110341. PubMed DOI

Sadighara P., Bekheir S.A., Shafaroodi H., Basaran B., Sadighara M. Tyramine, a biogenic agent in cheese: Amount and factors affecting its formation, a systematic review. Food Prod. Process. Nutr. 2024;6:30. doi: 10.1186/s43014-024-00223-x. DOI

Ritschard J.S., Schuppler M. The microbial diversity on the surface of smear-ripened cheeses and its impact on cheese quality and safety. Foods. 2024;13:214. doi: 10.3390/foods13020214. PubMed DOI PMC

Sablé S., Cottenceau G. Current knowledge of soft cheeses flavor and related compounds. J. Agr. Food Chem. 1999;47:4825–4836. doi: 10.1021/jf990414f. PubMed DOI

Commission Regulation (EU) No 702/2010 of 4 August 2010 Entering a Name in the Register of Protected Designations of Origin and Protected Geographical Indications (Olomoucké tvarůžky (PGI)) [(accessed on 2 December 2024)]. Available online: https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=CELEX%3A32010R0702.

Komprda T., Rejchrtová E., Sládková P., Zemánek L., Vymlátilová L. Effect of some external factors on the content of biogenic amines and polyamines in a smear-ripened cheese. Dairy. Sci. Technol. 2012;92:367–382. doi: 10.1007/s13594-012-0075-4. DOI

Olomoucké Tvarůžky Traditionally Unique. [(accessed on 30 November 2024)]. Available online: https://www.tvaruzky.cz/?lang=en.

Dadáková E., Křížek M., Pelikánová T. Determination of biogenic amines in foods using ultra-performance liquid chromatography (UPLC) Food Chem. 2009;116:365–370. doi: 10.1016/j.foodchem.2009.02.018. DOI

Cvak Z., Peterková L., Černá E. Chemical and Physico-Chemical Methods in Quality Control of Milk and Dairy Products. Výskumný ústav potravinářský; Praha, Czech Republic: 1992. p. 221.

Bockelmann W. Cheese|Smear-Ripened Cheeses. In: Fuquay J.W., editor. Encyclopedia of Dairy Sciences (Second Edition) Academic Press; San Diego, CA, USA: 2011. pp. 753–766.

Valdés-Stauber N., Scherer S., Seiler H. Identification of yeasts and coryneform bacteria from the surface microflora of brick cheeses. Int. J. Food Microbiol. 1997;34:115–129. doi: 10.1016/S0168-1605(96)01171-3. PubMed DOI

EFSA Scientific Opinion on Risk Based Control of Biogenic Amine Formation in Fermented Foods. 2011. [(accessed on 25 November 2024)]. Available online: https://www.efsa.europa.eu/en/efsajournal/pub/2393.

Food Standard Agency: Comitee of Toxicity. [(accessed on 25 November 2024)]; Available online: https://cot.food.gov.uk/

McCabe-Sellers B.J., Staggs C.G., Bogle M.L. Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge. J. Food Compos. Anal. 2006;19:S58–S65. doi: 10.1016/j.jfca.2005.12.008. DOI

Dingemanse J., Kleinbloesem C.H., Crevoisier C., Lankhaar G., Gasser U.E. Pharmacokinetic studies with a dual-release formulation of levodopa, a novel principle in the treatment of Parkinson’s disease. Eur. Neurol. 1998;39:119–124. doi: 10.1159/000007918. PubMed DOI

Sved A.F., Weeks J.J., Grace A.A., Smith T.T., Donny E.C. Monoamine oxidase inhibition in cigarette smokers: From preclinical studies to tobacco product regulation. Front. Neurosci. 2022;16:886496. doi: 10.3389/fnins.2022.886496. PubMed DOI PMC

Wöhrl S., Hemmer W., Focke M., Rappersberger K., Jarisch R. Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Allergy Asthma Proc. 2004;25:305–311. PubMed

Ferrante M.C., Mercogliano R. Focus on histamine production during cheese manufacture and processing: A review. Food Chem. 2023;419:136046. doi: 10.1016/j.foodchem.2023.136046. PubMed DOI

Madejska A., Michalski M., Osek J. Biogenic amines in rennet ripening cheeses as a health risk to consumers. Med. Weter. 2017;73:214–219. doi: 10.21521/mw.5681. DOI

Cwiková O., Franke G. Biogenic amines in smear ripened cheeses. Potravinarstvo Slovak J. Food Sci. 2019;13:378–384. doi: 10.5219/1105. PubMed DOI

Madejska A., Michalski M., Pawul-Gruba M., Osek J. Histamine content in rennet ripening cheeses during storage at different temperatures and times. J. Vet. Res. 2018;62:65–69. doi: 10.2478/jvetres-2018-0009. PubMed DOI PMC

Macků I., Lazárková Z., Buňka F., Hrabě J. Biogenic amine content in mould cheese during storage. Ecol. Chem. Eng. A. 2009;16:1591–1597.

Komprda T., Smělá D., Novická K., Kalhotka L., Šustová K., Pechová P. Content and distribution of biogenic amines in Dutch-type hard cheese. Food Chem. 2007;102:129–137. doi: 10.1016/j.foodchem.2006.04.041. DOI

Marijan A., Džaja P., Bogdanović T., Škoko I., Cvetnić Z., Dobranić V., Zdolec N., Šatrović E., Severin K. Influence of ripening time on the amount of certain biogenic amines in rind and core of cow milk Livno cheese. Mljekarstvo. 2014;64:159–169. doi: 10.15567/mljekarstvo.2014.0303. DOI

Gentès M.C., Caron A., St-Gelais D. Biogenic amine reduction in low-sodium Cheddar cheese: Probiotic cultures as an additional solution. Int. Dairy. J. 2024;148:105809. doi: 10.1016/j.idairyj.2023.105809. DOI

Bae I., Park J.H., Choi H.-Y., Jung H.-K. Emerging innovations to reduce the salt content in cheese; effects of salt on flavor, texture, and shelf life of cheese; and current salt usage: A review. Korean J. Food Sci. An. 2017;37:793–798. doi: 10.5851/kosfa.2017.37.6.793. PubMed DOI PMC

Ferroukhi I., Bord C., Lavigne R., Chassard C., Mardon J. Exploring alternative salting methods to reduce sodium content in blue-veined cheeses. Int. Dairy. J. 2023;138:105555. doi: 10.1016/j.idairyj.2022.105555. DOI

Tidona F., Zago M., Carminati D., Giraffa G. The reduction of salt in different cheese categories: Recent advances and future challenges. Front. Nutr. 2022;9:859694. doi: 10.3389/fnut.2022.859694. PubMed DOI PMC

Mietz J.L., Karmas E. Polyamine and histamine content of rockfish, salmon, lobster, and shrimp as an indicator of decomposition. J. Assoc. Off. Ana Chem. 1978;61:139–145. doi: 10.1093/jaoac/61.1.139. DOI

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...