Psychopathological Influences on Surgical and Clinical Outcomes in Lumbar Disk Herniation: Prediction Models and Literature Analysis
Status PubMed-not-MEDLINE Language English Country Switzerland Media electronic
Document type Journal Article
PubMed
39997325
PubMed Central
PMC11857040
DOI
10.3390/jpm15020048
PII: jpm15020048
Knihovny.cz E-resources
- Keywords
- lumbar disk herniation, predictive modeling, preoperative evaluation, psychological assessment, surgical outcomes,
- Publication type
- Journal Article MeSH
Background/Objectives: Lumbar disk herniation (LDH) significantly affects quality of life due to lower back and radiating leg pain. Surgical intervention, such as discectomy, is effective for symptom relief when conservative measures fail; however, psychological factors like anxiety, depression, and maladaptive coping strategies may negatively impact surgical outcomes. This study aims to assess the role of preoperative psychological evaluations in predicting postoperative recovery and to identify key psychological and functional predictors of surgical success. Methods: A prospective study was conducted on 888 patients undergoing microdiscectomy for LDH at Mater Olbia Hospital between December 2020 and December 2023. Preoperative evaluations included the Visual Analog Scale, Symptom Checklist 90-R, Oswestry Disability Index, and Short Form 36. Logistic regression models and ROC curve analysis were used to identify significant predictors of outcomes and evaluate model accuracy. Results: Preoperative pain levels and emotional well-being emerged as the strongest determinants of postoperative improvement in the Oswestry Disability Index. The predictive model demonstrated high specificity (90.2%) in identifying patients likely to benefit from surgery. Clinically significant improvements were achieved by 69% of patients, highlighting the importance of psychological and functional assessments. Conclusions: Preoperative psychological assessment is critical in predicting outcomes of lumbar disk herniation surgery. Addressing psychological factors preoperatively enhances recovery, supports personalized treatment planning, and improves patient education. These findings advocate for an integrated care model that considers both physical and psychological health, optimizing surgical outcomes and patient satisfaction.
Clinical Psychology Service Mater Olbia Hospital 07026 Olbia Italy
Department of Neurosurgery IRCCS Regina Elena National Cancer Institute 00144 Rome Italy
Department of Neurosurgery Mater Olbia Hospital 07026 Olbia Italy
Neurosurgical Training Center and Brain Research Mater Olbia Hospital 07026 Olbia Italy
Unit of Medical Physics Mater Olbia Hospital 07026 Olbia Italy
See more in PubMed
Zhang A.S., Xu A., Ansari K., Hardacker K., Anderson G., Alsoof D., Daniels A.H. Lumbar Disc Herniation: Diagnosis and Management. Am. J. Med. 2023;136:645–651. doi: 10.1016/j.amjmed.2023.03.024. PubMed DOI
Bruce L. Ehni Lumbar Discectomy. In: Steinmetz M.P., Berven S.H., Benzel E.C., editors. Benzel’s Spine Surgery. Volume 2. Elsevier; Philadelphia, PA, USA: 2016. pp. 799–803.
Jared B.C., Meic H.S. Lumbar Microdiscectomy: Indications and Techniques. In: Quinones-Hinojosa A., editor. Schmidek and Sweet Operative Neurosurgical Techniques. Volume 2. Elsevier; Philadelphia, PA, USA: 2022. pp. 1717–1729.
Masaud K., Galvin A.D., De Loughry G., Meachair A.O., Galea S., Shorten G. Preoperative Psychological Factors Influence Analgesic Consumption and Self-Reported Pain Intensity Following Breast Cancer Surgery. BMC Anesthesiol. 2024;24:239. doi: 10.1186/s12871-024-02622-6. PubMed DOI PMC
Wang S., Cardieri B., Mo Lin H., Liu X., Sano M., Deiner S.G. Depression and Anxiety Symptoms Are Related to Pain and Frailty but Not Cognition or Delirium in Older Surgical Patients. Brain Behav. 2021;11:e02164. doi: 10.1002/brb3.2164. PubMed DOI PMC
Giusti E.M., Manna C., Varallo G., Cattivelli R., Manzoni G.M., Gabrielli S., D’amario F., Lacerenza M., Castelnuovo G. The Predictive Role of Executive Functions and Psychological Factors on Chronic Pain after Orthopaedic Surgery: A Longitudinal Cohort Study. Brain Sci. 2020;10:685. doi: 10.3390/brainsci10100685. PubMed DOI PMC
La Rocca G., Galieri G., Mazzucchi E., Pignotti F., Orlando V., Pappalardo S., Olivi A., Sabatino G. The 3-Steps Approach for Lumbar Stenosis with Anatomical Insights, Tailored for Young Spine Surgeons. J. Pers. Med. 2024;14:985. doi: 10.3390/jpm14090985. PubMed DOI PMC
Varallo G., Suso-Ribera C., Ghiggia A., Veneruso M., Cattivelli R., Usubini A.G., Franceschini C., Musetti A., Plazzi G., Fontana J.M., et al. Catastrophizing, Kinesiophobia, and Acceptance as Mediators of the Relationship Between Perceived Pain Severity, Self-Reported and Performance-Based Physical Function in Women with Fibromyalgia and Obesity. J. Pain Res. 2022;15:3017–3029. doi: 10.2147/JPR.S370718. PubMed DOI PMC
Paulsen R.T., Rasmussen J., Carreon L.Y., Andersen M.Ø. Return to Work after Surgery for Lumbar Disc Herniation, Secondary Analyses from a Randomized Controlled Trial Comparing Supervised Rehabilitation versus Home Exercises. Spine J. 2020;20:41–47. doi: 10.1016/j.spinee.2019.09.019. PubMed DOI
Skolasky R.L., Finkelstein J.A., Schwartz C.E. Associations of Cognitive Appraisal and Patient Activation on Disability and Mental Health Outcomes: A Prospective Cohort Study of Patients Undergoing Spine Surgery. BMC Musculoskelet. Disord. 2024;25:595. doi: 10.1186/s12891-024-07709-2. PubMed DOI PMC
Wong J.J., Tricco A.C., Côté P., Liang C.Y., Lewis J.A., Bouck Z., Rosella L.C. Association Between Depressive Symptoms or Depression and Health Outcomes for Low Back Pain: A Systematic Review and Meta-Analysis. J. Gen. Intern. Med. 2022;37:1233–1246. doi: 10.1007/s11606-021-07079-8. PubMed DOI PMC
Dobran M., Nasi D., Gladi M., Marinelli M., Mancini F., Iacoangeli M., Scerrati M. Clinical and Psychological Outcome after Surgery for Lumbar Spinal Stenosis: A Prospective Observational Study with Analysis of Prognostic Factors. Neurol. Neurochir. Pol. 2018;52:70–74. doi: 10.1016/j.pjnns.2017.12.002. PubMed DOI
Strøm J., Bjerrum M.B., Nielsen C.V., Thisted C.N., Nielsen T.L., Laursen M., Jørgensen L.B. Anxiety and Depression in Spine Surgery—A Systematic Integrative Review. Spine J. 2018;18:1272–1285. doi: 10.1016/j.spinee.2018.03.017. PubMed DOI
Galieri G., Mazzucchi E., Pignotti F., Rinaldi P., De Santis V., La Rocca G., Sabatino G. Lumbo-Sacral Pedicular Aplasia Diagnosis and Treatment: A Systematic Literature Review and Case Report. Br. J. Neurosurg. 2022;38:1269–1275. doi: 10.1080/02688697.2022.2057431. PubMed DOI
Shafshak T.S., Elnemr R. The Visual Analogue Scale Versus Numerical Rating Scale in Measuring Pain Severity and Predicting Disability in Low Back Pain. J. Clin. Rheumatol. 2021;27:282–285. doi: 10.1097/RHU.0000000000001320. PubMed DOI
Begum M.R., Hossain M.A. Validity and Reliability of Visual Analogue Scale (Vas) for Pain Measurement. J. Med. Case Rep. Rev. 2019;2:394–402.
Kostaras P., Martinaki S., Asimopoulos C., Maltezou M., Papageorgiou C. The Use of the Symptom Checklist 90-R in Exploring the Factor Structure of Mental Disorders and the Neglected Fact of Comorbidity. Psychiatry Res. 2020;294:113522. doi: 10.1016/j.psychres.2020.113522. PubMed DOI
Lignier B., Petot J.M., Canada B., Nicolas M., Courtois R., De Oliveira P. The Structure of the Symptom Checklist-90-Revised: Global Distress, Somatization, Hostility, and Phobic Anxiety Scales Are Reliable and Robust across Community and Clinical Samples from Four European Countries. Psychiatry Res. 2024;331:115635. doi: 10.1016/j.psychres.2023.115635. PubMed DOI
Derogatis L.R. SCL-90-R: Administration, Scoring & Procedures Manual-II for the (Revised) Version and Other Instruments of the Psychopathology Rating Scale Series. 2nd ed. Clinical Psychometric Research, Inc.; Towson, MD, USA: 1992. pp. 1–16.
Koivunen K., Widbom-Kolhanen S., Pernaa K., Arokoski J., Saltychev M. Reliability and Validity of Oswestry Disability Index among Patients Undergoing Lumbar Spinal Surgery. BMC Surg. 2024;24:13. doi: 10.1186/s12893-023-02307-w. PubMed DOI PMC
Jamjoom A.B., Gahtani A.Y., Alzahrani M.T., Albeshri A.S., Sharab M.A. Review of the Most Cited Patient-Reported Outcome Measure (PROM) Studies Published in the Neurospine Surgical Literature. Cureus. 2023;15:e44262. doi: 10.7759/cureus.44262. PubMed DOI PMC
Apolone G., Mosconi P. The Italian SF-36 Health Survey: Translation, Validation and Norming. J. Clin. Epidemiol. 1998;51:1025–1036. doi: 10.1016/S0895-4356(98)00094-8. PubMed DOI
Shawky Abdelgawaad A., El-Sharkawi M., Sarhan A.M., Hassanien M.A., Aziz M. Validation of the Arabic Version of the EuroQol-5-Dimension 5-Level (EQ-5D-5 L) in Patients with Spinal Degenerative Diseases. BMC Public Health. 2024;24:1119. doi: 10.1186/s12889-024-18367-3. PubMed DOI PMC
Unoka Z., Csáky-Pallavicini K., Horváth Z., Demetrovics Z., Maraz A. The Inventory of Personality Organization: A Valid Instrument to Detect the Severity of Personality Dysfunction. Front. Psychiatry. 2022;13:995726. doi: 10.3389/fpsyt.2022.995726. PubMed DOI PMC
La Rocca G., Galieri G., Mazzucchi E., Pignotti F., Orlando V., Pappalardo S., Olivi A., Sabatino G. The Three-Step Approach for Lumbar Disk Herniation with Anatomical Insights Tailored for the Next Generation of Young Spine Surgeons. J. Clin. Med. 2024;13:3571. doi: 10.3390/jcm13123571. PubMed DOI PMC
Taylor J.R. An Introduction to Error Analysis: The Study of Uncertainties in Physical Measurements. University Science Book; Melville, NY, USA: 2022. pp. 173–178.
Mazzucchi E., La Rocca G., Cusumano D., Bazzu P., Pignotti F., Galieri G., Rinaldi P., De Santis V., Sabatino G. The Role of Psychopathological Symptoms in Lumbar Stenosis: A Prediction Model of Disability after Lumbar Decompression and Fusion. Front. Psychol. 2023;14:1070205. doi: 10.3389/FPSYG.2023.1070205/BIBTEX. PubMed DOI PMC
Gladwin T.E. An Implementation of N-Way Repeated Measures ANOVA: Effect Coding, Automated Unpacking of Interactions, and Randomization Testing. MethodsX. 2020;7:100947. doi: 10.1016/j.mex.2020.100947. PubMed DOI PMC
Pan S., Liu Z., Han Y., Zhang D., Zhao X., Li J., Wang K. Using the Pearson’s Correlation Coefficient as the Sole Metric to Measure the Accuracy of Quantitative Trait Prediction: Is It Sufficient? Front. Plant Sci. 2024;15:1480463. doi: 10.3389/fpls.2024.1480463. PubMed DOI PMC
Santos M.M.G., Beijo L.A., Avelar F.G., Petrini J. Statistical Methods for Identification of Golden Ratio. Biosystems. 2020;189:104080. doi: 10.1016/j.biosystems.2019.104080. PubMed DOI
Nahm F.S. Receiver Operating Characteristic Curve: Overview and Practical Use for Clinicians. Korean J. Anesthesiol. 2022;75:25–36. doi: 10.4097/kja.21209. PubMed DOI PMC
Kelley D.E. Oceanographic Analysis with R. Springer; New York, NY, USA: 2018. DOI
Gatta R., Vallati M., Dinapoli N., Masciocchi C., Lenkowicz J., Cusumano D., Casá C., Farchione A., Damiani A., van Soest J., et al. Towards a Modular Decision Support System for Radiomics: A Case Study on Rectal Cancer. Artif. Intell. Med. 2019;96:145–153. doi: 10.1016/j.artmed.2018.09.003. PubMed DOI
Mandrekar J.N. Receiver Operating Characteristic Curve in Diagnostic Test Assessment. J. Thorac. Oncol. 2010;5:1315–1316. doi: 10.1097/JTO.0b013e3181ec173d. PubMed DOI
Mu W., Shang Y., Zhang C., Tang S. Analysis of the Depression and Anxiety Status and Related Risk Factors in Patients with Lumbar Disc Herniation. Pak. J. Med. Sci. 2019;35:658–662. doi: 10.12669/pjms.35.3.299. PubMed DOI PMC
Yilmaz E., Çikrikçioǧlu H.Y., Baydur H. The Effect of Functional Disability and Quality of Life on Decision to Have Surgery in Patients With Lumbar Disc Herniation. Orthop. Nurs. 2018;37:246–252. doi: 10.1097/NOR.0000000000000466. PubMed DOI
Ionescu D., Iacob C.I., Brehar F.M., Avram E. The Role of Catastrophizing and Basic Psychological Needs Satisfaction on Health-Related Quality of Life and Pain in Patients with Lumbar Disc Herniation. Front. Psychol. 2023;14:1147254. doi: 10.3389/fpsyg.2023.1147254. PubMed DOI PMC
Shin J.W., Park Y., Park S.H., Ha J.W., Jung W.S., Kim H.S., Suk K.S., Park S.Y., Moon S.H., Lee B.H., et al. Association of Untreated Pre-Surgical Depression With Pain and Outcomes After Spinal Surgery. Glob. Spine J. 2024:21925682241260642. doi: 10.1177/21925682241260642. PubMed DOI PMC
Andersen M., Andresen A.K., Carreon L.Y., Pedersen C.F. Impact of Preoperative Duration of Symptoms on Patient Satisfaction, Outcomes and Complications After Lumbar Discectomy: A Propensity-Matched Comparison. Spine. 2023;48:1191–1196. doi: 10.1097/BRS.0000000000004692. PubMed DOI PMC
Shaygan M., Zamani M., Jaberi A., Eghbal K., Dehghani A. The Impact of Physical and Psychological Pain Management Training on Pain Intensity, Anxiety and Disability in Patients Undergoing Lumbar Surgeries. Spine J. 2023;23:656–664. doi: 10.1016/j.spinee.2023.01.016. PubMed DOI
Van Bogaert W., Tegner H., Coppieters I., Huysmans E., Nijs J., Moens M., Goudman L., Buyl R., Lundberg M. The Predictive Value of Fear Avoidance Beliefs for Outcomes Following Surgery for Lumbar Degenerative Disease: A Systematic Review and Best Evidence Synthesis. Pain Physician. 2022;25:441–457. PubMed
Apaydin A.S., Bozyiğit B., Koç-Apaydin Z., Güneş M., Yana M. Effects of Different Surgical Treatments on Pain, Disability, Anxiety and Quality of Life in Lumbar Disc Herniation. Cir. Cir. 2024;92:39–45. doi: 10.24875/CIRUE.M24000610. PubMed DOI
Ricciardi L., Piazza A., Capobianco M., Della Pepa G.M., Miscusi M., Raco A., Scerrati A., Somma T., Lofrese G., Sturiale C.L. Lumbar Interbody Fusion Using Oblique (OLIF) and Lateral (LLIF) Approaches for Degenerative Spine Disorders: A Meta-Analysis of the Comparative Studies. Eur. J. Orthop. Surg. Traumatol. 2023;33:1–7. doi: 10.1007/s00590-021-03172-0. PubMed DOI
Cerezci O., Başak A.T. Importance of Physiotherapy after Lumbar Microdiscectomy. Turk. Neurosurg. 2023;33:150–155. doi: 10.5137/1019-5149.JTN.40904-22.5. PubMed DOI
Jitpakdee K., Liu Y., Kim Y.J., Kotheeranurak V., Kim J. sung Factors Associated with Incomplete Clinical Improvement in Patients Undergoing Transforaminal Endoscopic Lumbar Discectomy for Lumbar Disc Herniation. Eur. Spine J. 2023;32:2700–2708. doi: 10.1007/s00586-023-07636-1. PubMed DOI
Meyers E., Vlaeyen J.W.S., van den Broeke E.N., von Leupoldt A., Palmer A.J., Torta D.M. The Effect of High versus Low Cognitive Load on the Development of Nociceptive Hypersensitivity: The Roles of Sympathetic Arousal, Sex and Pain-Related Fear. Eur. J. Pain. 2023;27:682–698. doi: 10.1002/ejp.2098. PubMed DOI
Xiao W., Yang H., Hao Z., Li M., Zhao M., Zhang S., Zhang G., Mao H., Wang C. Relationship between Fear-Avoidance Beliefs and Reaction Time Changes Prior to and Following Exercise-Induced Muscle Fatigue in Chronic Low Back Pain. Pain Res. Manag. 2024;2024:9982411. doi: 10.1155/2024/9982411. PubMed DOI PMC
Kim D.J., Mirmina J., Narine S., Wachtel J., Carbajal J.M., Fox H., Cáceda R. Altered Physical Pain Processing in Different Psychiatric Conditions. Neurosci. Biobehav. Rev. 2022;133:104510. doi: 10.1016/j.neubiorev.2021.12.033. PubMed DOI
Battistelli M., Mazzucchi E., Muselli M., Polli F.M., Galieri G., Bazzu P., Pignotti F., Olivi A., Sabatino G., La Rocca G. The Role of Psychosomatic Traits in Tailored Workup for Anterior Cervical Discectomy and Fusion-A Case Series. J. Pers. Med. 2024;14:454. doi: 10.3390/jpm14050454. PubMed DOI PMC
La Rocca G., Orlando V., Galieri G., Mazzucchi E., Pignotti F., Cusumano D., Bazzu P., Olivi A., Sabatino G. Mindfulness vs. Physiotherapy vs. Medical Therapy: Uncovering the Best Postoperative Recovery Method for Low Back Surgery Patients during the COVID-19 Pandemic-A Single Institution’s Experience. J. Pers. Med. 2024;14:917. doi: 10.3390/jpm14090917. PubMed DOI PMC
Harris A.B., Marrache M., Puvanesarajah V., Raad M., Jain A., Kebaish K.M., Riley L.H., Skolasky R.L. Are Preoperative Depression and Anxiety Associated with Patient-Reported Outcomes, Health Care Payments, and Opioid Use after Anterior Discectomy and Fusion? Spine J. 2020;20:1167–1175. doi: 10.1016/j.spinee.2020.03.004. PubMed DOI
Lanini I., Amass T., Calabrisotto C.S., Fabbri S., Falsini S., Adembri C., Di Filippo A., Romagnoli S., Villa G. The Influence of Psychological Interventions on Surgical Outcomes: A Systematic Review. J. Anesth. Analg. Crit. Care. 2022;2:31. doi: 10.1186/s44158-022-00057-4. PubMed DOI PMC