Behavioral comorbidities of early-life seizures: Insights from developmental studies in rats
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
40015055
DOI
10.1016/j.yebeh.2025.110307
PII: S1525-5050(25)00046-0
Knihovny.cz E-resources
- Keywords
- Animal models, Behavior, Development, Early life seizures, Epilepsy, Rat,
- MeSH
- Behavior, Animal * physiology MeSH
- Mental Disorders * etiology MeSH
- Comorbidity MeSH
- Rats MeSH
- Humans MeSH
- Disease Models, Animal MeSH
- Seizures * complications psychology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Childhood epilepsy is frequently associated with neurobehavioral comorbidities such as depression, anxiety, cognitive impairments, and social dysfunction, as revealed by both clinical and experimental studies. Despite extensive neurophysiological research, behavioral studies in developing animals remain limited and underreported. Here, we review the behavioral impact of early-life seizures (ELSs) in commonly used rat models in developmental studies. We outline suitable tests and provide guidance on how traditional tests should be adapted and interpreted in this context. Finally, we examine factors influencing behavioral analysis in developmental studies, exploring confounding variables and offering strategies to minimize their impact.
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