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Risk and protective factors in the origin of atrial septal defect secundum--national population-based case-control study
M. Csáky-Szunyogh, A. Vereczkey, R. Urbán, A. E. Czeizel
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't
Digital library NLK
Source
NLK
Free Medical Journals
from 2004
ProQuest Central
from 2009-03-01 to 6 months ago
Medline Complete (EBSCOhost)
from 2006-03-01 to 6 months ago
Nursing & Allied Health Database (ProQuest)
from 2009-03-01 to 6 months ago
Health & Medicine (ProQuest)
from 2009-03-01 to 6 months ago
Public Health Database (ProQuest)
from 2009-03-01 to 6 months ago
ROAD: Directory of Open Access Scholarly Resources
from 1993
PubMed
24844106
DOI
10.21101/cejph.a3824
Knihovny.cz E-resources
- MeSH
- Heart Septal Defects, Atrial etiology prevention & control MeSH
- Phenolphthalein adverse effects MeSH
- Pregnancy Complications * MeSH
- Folic Acid administration & dosage MeSH
- Humans MeSH
- Mothers MeSH
- Infant, Newborn MeSH
- Pelvic Inflammatory Disease complications MeSH
- Tachycardia, Paroxysmal complications MeSH
- Risk Factors MeSH
- Mental Recall MeSH
- Case-Control Studies MeSH
- Tachycardia, Supraventricular complications MeSH
- Population Surveillance MeSH
- Pregnancy MeSH
- Bias MeSH
- Self Report MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Hungary MeSH
The aim of this study was to assess the risk factors in the origin of lethal or surgically corrected isolated atrial septal defect secundum. The population-based Hungarian Case-Control Surveillance of Congenital Abnormalities (conducted between 1980 and 1996) comprised 472 atrial septal defect secundum cases, 678 matched controls and 38,151 available controls without any defects; in addition, 21,022 malformed controls with other isolated defects. Medically recorded chronic disorders in the prenatal maternity logbook were evaluated, while acute maternal diseases, drug treatments and pregnancy supplements were analyzed on the basis of both prospective medically recorded data and retrospective maternal information. Acute pelvic inflammatory disease, paroxysmal supraventricular tachycardia and phenolphthalein treatment due to severe constipation of mothers were shown to contribute to the development of atrial septal defect secundum of their children. High doses of folic acid in early pregnancy had positively influenced a minor part of isolated atrial septal defect secundum in foetuses. In conclusion, the obvious genetic predisposition for atrial septal defect secundum is connected with maternal paroxysmal supraventricular tachycardia and triggered by acute pelvic inflammatory diseases and phenolphthalein treatment, while the manifestation of atrial septal defect secundum can be reduced by high doses of folic acid supplementation in early pregnancy.
Eötvös Loránd University Institute of Psychology Budapest Hungary
Foundation for the Community Control of Hereditary Diseases Budapest Hungary
National Centre for Healthcare Audit and Inspection Budapest Hungary
Versys Clinics Human Reproduction Institute Budapest Hungary
References provided by Crossref.org
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