Pharmacokinetics of the systemic application of hyaluronic acid for joint arthritis treatment
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
40074120
DOI
10.1016/j.ijbiomac.2025.141937
PII: S0141-8130(25)02488-2
Knihovny.cz E-resources
- Keywords
- Hyaluronan, Inflammation, Intraperitoneal, Intravenous, Pharmacokinetics, Rheumatoid arthritis, Stable isotope, Vascular leakage,
- MeSH
- Arthritis, Experimental * chemically induced drug therapy metabolism MeSH
- Injections, Intra-Articular MeSH
- Injections, Intravenous MeSH
- Joints * drug effects pathology MeSH
- Hyaluronic Acid * administration & dosage pharmacokinetics MeSH
- Disease Models, Animal MeSH
- Mice MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hyaluronic Acid * MeSH
Frequent degenerative joint diseases, known as arthritis, are characterized by joint inflammation and cartilage breakdown. Various arthritis types are traditionally managed with intraarticular injections of hyaluronan or its derivatives. However, intravenous administration of hyaluronan is emerging as a vital alternative, particularly because intraarticular injections can be challenging for clinicians when targeting small or swollen joints. Pharmacokinetics of intravenously and intraperitoneally administered middle-Mw hyaluronan were studied in an adjuvant-induced arthritis mouse model alongside therapeutic effects. Using 13C-, biotin- and fluoresce-labeling, we found hyaluronan accumulated in inflamed joint tissues while distribution in other organs remained similar to healthy controls. Repeated administrations significantly reduced arthritis symptoms like swelling and redness, RANKL, inducible nitric oxide synthase, COMP and prostaglandin E2 levels. Moreover, hyaluronan treatment prevented dextran-FITC penetration into inflamed paws suggesting reduced vascular permeability at the site of inflammation. These findings support systemic hyaluronan administration as a promising arthritis treatment strategy.
Contipro a s Dolní Dobrouč Czech Republic
Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic
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