European Consensus on Malabsorption-UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN: Part 2: Screening, Special Populations, Nutritional Goals, Supportive Care, Primary Care Perspective

. 2025 Jun ; 13 (5) : 773-797. [epub] 20250315

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu konsensus - konference, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid40088199

Grantová podpora
United European Gastroenterology
University of Pavia

Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac disease (CD) and other enteropathies, lactase deficiency, small intestinal bacterial overgrowth (SIBO), autoimmune atrophic gastritis, Crohn's disease, and gastric or small bowel resections. Early recognition of malabsorption is key for tailoring a proper diagnostic work-up for identifying the cause of malabsorption. Patient's medical and pharmacological history are essential for identifying risk factors. Several examinations like endoscopy with small intestinal biopsies, non-invasive functional tests, and radiologic imaging are useful in diagnosing malabsorption. Due to its high prevalence, CD should always be looked for in case of malabsorption with no other obvious explanations and in high-risk individuals. Nutritional support is key in management of patients with malabsorption; different options are available, including oral supplements, enteral or parenteral nutrition. In patients with short bowel syndrome, teduglutide proved effective in reducing the need for parenteral nutrition, thus improving the quality of life of these patients. Primary care physicians have a central role in early detection of malabsorption and should be involved into multidisciplinary teams for improving the overall management of these patients. In this European consensus, involving 10 scientific societies and several experts, we have dissected all the issues around malabsorption, including the definitions and diagnostic testing (Part 1), high-risk categories and special populations, nutritional assessment and management, and primary care perspective (Part 2).

1st Department of Internal Medicine Fondazione IRCCS San Matteo Pavia Italy

2nd Department of Internal Medicine Gastroenterology University Hospital Hradec Králové Charles University Faculty of Medicine in Hradec Králové Hradec Kralove Czech Republic

2nd Department of Internal Medicine Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca Romania

2nd Medical Department Emergency Clinical County Hospital Cluj Napoca Romania

4th Local Primary Care Team Municipality Practice and Academic Practice of Heraklion University of Crete Crete Greece

CEMAD Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy

Centre for Chronic Intestinal Failure IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy

Centre of Gastroenterology Hepatology and Nutrition Pauls Stradiņš Clinical University Hospital Riga Latvia

Clinic for General Medicine Gastroenterology and Infectious Diseases Augustinerinnen Hospital Cologne Germany

Department of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria

Department of Gastroenterology Digestive Oncology and Hepatopancreatology HUB Hôpital Erasme Université Libre de Bruxelles Brussels Belgium

Department of Gastroenterology Hepatology and Nutrition University of Zagreb Zagreb School of Medicine University Hospital Centre Zagreb Zagreb Croatia

Department of Hepatogastroenterology IKEM Prague Czech Republic

Department of Internal Diseases Rīga Stradiņš University Riga Latvia

Department of Internal Medicine and Medical Therapeutics University of Pavia Pavia Italy

Department of Medical and Surgical Sciences University of Bologna Bologna Italy

Department of Paediatrics Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

Department of Translational Medicine and Surgery Università Cattolica del Sacro Cuore Rome Italy

Division of Gastroenterology and Hepatology Department of Internal Medicine Medical University Graz Austria

Egas Moniz Center for Interdisciplinary Research Egas Moniz School of Health and Science Almada Portugal

Endocrinology and Nutrition Department Hospital Universitari Vall d'Hebron Diabetes and Metabolism Research Unit Vall d'Hebron Institut de Recerca Universitat Autonoma de Barcelona Barcelona Spain

Faculty of Medicine University of Maribor Maribor Slovenia

Gastroenterology and Nutrition Centre Hospitalier Universitaire de Nice Université Côte d'Azur Nice France

Gastroenterology Department Hospital Garcia de Orta Almada Portugal

Israelitic Hospital Academic Hospital University of Hamburg Hamburg Germany

La Mina Primary Health Care Academic Centre Catalan Health Institute University of Barcelona Barcelona Spain

Laboratory of Health and Society School of Medicine University of Crete Heraklion Greece

Paediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Universitari Vall d'Hebron Barcelona Hospital Campus Barcelona Spain

Pediatric Gastroenterology Hepatology and Nutrition Unit Pediatric Department University Medical Center Maribor Maribor Slovenia

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