BACKGROUND: Patients with oligodendroglioma have a relatively favourable prognosis. The long-term impacts of the tumour itself and its treatment on health-related quality of life (HRQOL) and cognition remain largely unclear. We investigated associations between treatment and functioning of survivors of oligodendroglioma. METHODS: In this cross-sectional observational study, patients with oligodendroglioma, isocitrate dehydrogenase-mutant and 1p/19q-codeleted, diagnosed ≥5 years ago, were recruited. Patients completed patient-reported outcome measures (EORTC QLQ-C30; BN20; MOS Cognitive Complaints Scale) and cognitive tests (HVLT-R, TMT, COWAT). Associations between HRQOL and cognition outcomes, and clinical variables (time since diagnosis; age at diagnosis; progression; tumour location; treatments delivered; time since treatment; current medication;) were explored with regression analyses. RESULTS: In total, 237 patients M=9.9 years post-diagnosis (sd=4.2, range 5.0-25.8) took part from 33 sites across 9 countries. Clinically relevant levels of impairment were noted in >40% of patients on EORTC QLQ-C30 scales for cognitive functioning (56.1%), emotional functioning (49.8%), fatigue (45.1%), and physical functioning (40.5%). In individuals, cognitive impairment ranged from 17.7% for processing speed to 46.0% for episodic verbal memory (delayed recall). Among other clinical factors such as current use of antiseizure medication or antidepressants, age, disease progression, time since diagnosis and time since treatment, and radiotherapy treatment (ever received) was linked to HRQOL and cognitive functioning outcomes (post-hoc analyses for cumulative radiotherapy dose: not significant). CONCLUSIONS: In oligodendroglioma survivors, HRQOL and cognitive impairment are prevalent even years into follow-up. Supportive care and rehabilitation should be prioritized to mitigate these challenges and improve daily functioning. TRIAL REGISTRATION: NCT04708548.

3rd Oncology Department Hygeia Hospital Athens Greece

Aix Marseille Univ CNRS INP Inst Neurophysiopathol GlioME Team APHM CHU Timone Service de Neurooncologie Réseau Préclinique et Translationnel de Recherche en Neuro oncologie Marseille France

Amsterdam UMC location Vrije Universiteit Amsterdam Medical Psychology Boelelaan 1117 Amsterdam The Netherlands

Cambridge University Hospitals NHS Foundation Trust Cambridge UK

Cancer Centre University Hospitals Birmingham Edgbaston Birmingham B15 2TH UK

Centre Francois Baclesse Caen France

Competence Center Palliative Care Dept of Radiation Oncology University Hospital and University of Zurich Zurich Switzerland

Comprehensive Cancer Center Central Germany Jena Campus Jena Germany

Department of Clinical Oncology The Christie NHS FT Manchester UK

Department of Experimental and Clinical Biomedical Sciences M Serio University of Florence Florence Italy

Department of Geriatrics and Palliative Medicine and Division of Cell and Neurobiology Department of Biomedical and Clinical Sciences Linköping University Linköping Sweden EV Centre Eugène Marquis Medical Oncology INSERM U1242 University of Rennes Rennes France

Department of Medical Oncology Montpellier Cancer Institute University of Montpellier Montpellier France

Department of Neurology Côte d'Azur University Nice France

Department of Neurology Sahlgrenska University Hospital Sweden

Department of Neurology University Hospital and University of Zurich Zurich Switzerland

Department of Neurooncology Center for Neurology University Hospital Bonn Bonn Germany

Department of Neurosurgery Jena University Hospital Friedrich Schiller University Jena Jena Germany

Department of Neurosurgery King's College Hospital London UK

Department of Neurosurgery Pellegrin Hospital Bordeaux University Hospital Center Bordeaux France

Department of Oncology Odense University Hospital Odense Denmark

Department of Palliative and Supportive Care Montpellier Cancer Institute Univ Montpellier Montpellier France

Department of Radiation Oncology Masaryk Memorial Cancer Institute and Faculty of Medicine Masaryk University Brno Czech Republic

Dept of Clinical Research University of Southern Denmark Odense Denmark

Dept of Neurology Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

Desbrest Institute of Epidemiology and Public Health Univ Montpellier INSERM Montpellier France

Goethe University Frankfurt University Hospital Dr Senckenberg Institute of Neurooncology Frankfurt Germany

Hospices Civils de Lyon Hôpital Neurologique Neuro oncology Department Lyon France

Hospices Civils de Lyon Hôpital Neurologique Neuro oncology Department; Cancer Research Center of Lyon Claude Bernard University Lyon France

INSERM U1240 Imagerie Moléculaire et Stratégies Théranostiques Université Clermont Auvergne Clermont Ferrand F 63000 France ; 2 Centre d'Investigation Clinique UMR501 Clermont Ferrand F 63000 France ; Département de Recherche Clinique Délégation Recherche Clinique et Innovation Centre Jean PERRIN Clermont Ferrand F 63000 France ; Service d'oncologie médicale Centre Jean PERRIN Clermont Ferrand F 63000 France

Institute for Neuroscience and Physiology University of Gothenburg Sweden

Institute of Functional Genomics IGF University of Montpellier CNRS INSERM Montpellier France

Leeds Institute of Health Sciences Faculty of Medicine and Health University of Leeds Leeds LS2 9JT United Kingdom

Leeds Institute of Medical Research at St James's St James's University Hospital University of Leeds Leeds LS9 7TF United Kingdom

Nottingham University Hospitals NHS Foundation Trust Nottingham UK

Radiation Oncology Unit Oncology Department Azienda Ospedaliero Universitaria Careggi Florence Italy

radiotherapy department Institut de Cancérologie de Strasbourg Europe 17 rue Albert Calmette F 67200 Strasbourg France

Research Centre for Applied Molecular Oncology Masaryk Memorial Cancer Institute Brno Czech Republic

Rigshospitalet Copenhagen Denmark

Sheffield Centre for Health and Related Research University of Sheffield Sheffield S1 4DA

Sorbonne Université AP HP Hôpitaux Universitaires La Pitié Salpêtrière Charles Foix DMU Neurosciences Service de Neuro oncologie F 75013 Paris France

Tayside NHS Trust Dundee UK

The Clatterbridge Cancer Centre NHS Foundation Trust Clatterbridge Road Bebington Wirral CH634JY United Kingdom

The Oncology Department and Danish Center for Particle Therapy Aarhus University Hospital Denmark

The Royal Marsden NHS Foundation Trust London UK

Tubingen University Hospital Tubingen Germany

Citace poskytuje Crossref.org

Zobrazit více v PubMed

ClinicalTrials.gov
NCT04708548