Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer. The findings imply that the deregulation of the mTOR pathway in cancer provides a compelling basis for therapeutic treatments. Phytochemicals such as flavonoids and polyphenols have been shown to play a key role in suppressing different kinases implicated in PI3K/AKT/mTOR signaling cascades. A thorough study of the molecular connections between bioactive substances, mTOR signaling, and autophagy activation can lead to the creation of personalized treatments that work better and have fewer side effects. Finding out how important it is to target the mTOR pathway and how to use bioactive chemicals from plants to treat cancer are both important discoveries that could lead to more precise medicine and the development of effective cancer drugs. Finally, targeting mTOR pathways using plant-derived chemicals may be a promising therapy strategy for cancer. This review tries to summarize putative plant bioactive chemicals that act on malignancies via mTOR signaling pathways. Furthermore, the paper discusses the role of the mTOR pathway in cancer, specifically its influence on cell growth, proliferation, and survival.

Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic

Center for Basic and Applied Science Faculty of Informatics and Management University of Hradec Kralove Hradec Kralove Czech Republic

Centre of Advanced Innovation Technologies VSB Technical University of Ostrava Ostrava Poruba Czech Republic

Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh

Faculty of Science University of Hradec Kralove Hradec Kralove Czech Republic

Pharmacy Discipline Khulna University Khulna Bangladesh

School of Bioengineering and Food Technology Shoolini University of Biotechnology and Management Sciences Solan India

School of Biological and Environmental Science Shoolini University of Biotechnology and Management Sciences Solan India

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