perilipiny [Perilipins] tematický

Termíny

perilipinové proteiny

 

PAT Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
PLIN Proteins

Perzistentní odkaz   https://www.medvik.cz/link/D000070137
Definice

A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.

DUI
D000070137
CUI
M000609416
Předchozí užití
Carrier Proteins (1991-2016)
Historická pozn.
2017
Veřejná pozn.
2017