A perilipin that localizes to LIPID DROPLETS; CYTOPLASM; ENDOSOMES; and PLASMA MEMBRANE, especially in MACROPHAGES. It functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. It is also required for the transport of the MANNOSE-6-PHOSPHATE RECEPTOR from endosomes to the TRANS-GOLGI NETWORK. Its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.

DUI

D000070796 MeSH Browser

CUI

M000612258

History note

2017 (1983)

Public note

2017; PERILIPIN-3 was indexed under CARRIER PROTIENS 1983-2004; under DNA-BINDING PROTEINS, INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS, and PREGNANCY PROTEINS 1983-2011; and under VESICULAR TRANSPORT PROTEINS 2011-2016 1983-2011