ADAMTS13 Protein [protein ADAMTS13]

topical
17
Terms

metalloproteáza štěpící velké multimery von Willebrandova faktoru
proteáza ADAMTS13
proteáza štěpící von Willebrandův faktor
protein ADAMTS-13
vWF:CP

 

A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
ADAMTS-13 Protein
ADAMTS13 Protease
von Willebrand Factor-Cleaving Protease
vWF-Cleaving Protease

Persistent link   https://www.medvik.cz/link/D000071120
Definition

An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.

DUI
D000071120 MeSH Browser
CUI
M000613168
Previous indexing
ADAM Proteins (2006-2016)
History note
2017
Public note
2017

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 2
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 4
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 5
DE
drug effects 0
EC
economics 0
GE
genetics 2
HI
history 0
IM
immunology 1
IP
isolation & purification 0
ME
metabolism 8
PK
pharmacokinetics 1
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 559
D08.811.277.656.675 Metalloproteases 57
D08.811.277.656.675.374 Metalloendopeptidases 39
D08.811.277.656.675.374.102 ADAM Proteins 14
D08.811.277.656.675.374.102.500 ADAMTS Proteins
D08.811.277.656.675.374.102.500.500 ADAMTS1 Protein
D08.811.277.656.675.374.102.500.813 ADAMTS13 Protein 17
D08.811.277.656.675.374.102.500.844 ADAMTS4 Protein
D08.811.277.656.675.374.102.500.875 ADAMTS5 Protein
D08.811.277.656.675.374.102.500.937 ADAMTS7 Protein
D08.811.277.656.675.374.102.500.968 ADAMTS9 Protein
D09 Carbohydrates 723
D09.400 Glycoconjugates 58
D09.400.430 Glycoproteins 637
D09.400.430.500 ADAM Proteins 14
D09.400.430.500.500 ADAMTS Proteins
D09.400.430.500.500.500 ADAMTS1 Protein
D09.400.430.500.500.813 ADAMTS13 Protein 17
D09.400.430.500.500.844 ADAMTS4 Protein
D09.400.430.500.500.875 ADAMTS5 Protein
D09.400.430.500.500.937 ADAMTS7 Protein
D09.400.430.500.500.968 ADAMTS9 Protein
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.395 Glycoproteins 637
D12.776.395.033 ADAM Proteins 14
D12.776.395.033.500 ADAMTS Proteins
D12.776.395.033.500.500 ADAMTS1 Protein
D12.776.395.033.500.813 ADAMTS13 Protein 17
D12.776.395.033.500.844 ADAMTS4 Protein
D12.776.395.033.500.875 ADAMTS5 Protein
D12.776.395.033.500.937 ADAMTS7 Protein
D12.776.395.033.500.968 ADAMTS9 Protein
D12.776.860 Scleroproteins 5
D12.776.860.300 Extracellular Matrix Proteins 138
D12.776.860.300.085 ADAMTS Proteins
D12.776.860.300.085.500 ADAMTS1 Protein
D12.776.860.300.085.813 ADAMTS13 Protein 17
D12.776.860.300.085.844 ADAMTS4 Protein
D12.776.860.300.085.875 ADAMTS5 Protein
D12.776.860.300.085.937 ADAMTS7 Protein
D12.776.860.300.085.968 ADAMTS9 Protein

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