Suppressor of Cytokine Signaling 3 Protein [protein SOCS3]
topical
1
- Terms
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SOCS3 protein
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SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
Persistent link
https://www.medvik.cz/link/D000071223
Definition
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
- DUI
- D000071223 MeSH Browser
- CUI
- M000613666
- Previous indexing
- Suppressor of Cytokine Signaling Proteins (2006-2016); Repressor Proteins (1997-2016); Transcription Factors (1997-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
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Occurrences in Medvik records
D
Chemicals and Drugs
D12.644.360.024.374.500
Suppressor of Cytokine Signaling 1 Protein
D12.776.157.057.249.500
Suppressor of Cytokine Signaling 1 Protein
D12.776.476.024.437.500
Suppressor of Cytokine Signaling 1 Protein