A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

DUI

D000071223 MeSH Prohlížeč

CUI

M000613666

Předchozí užití

Suppressor of Cytokine Signaling Proteins (2006-2016); Repressor Proteins (1997-2016); Transcription Factors (1997-2016)

Historická pozn.

2017

Veřejná pozn.

2017