Suppressor of Cytokine Signaling 3 Protein [protein SOCS3]
- Terms
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SOCS3 protein
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SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
- DUI
- D000071223 MeSH Browser
- CUI
- M000613666
- Previous indexing
- Suppressor of Cytokine Signaling Proteins (2006-2016); Repressor Proteins (1997-2016); Transcription Factors (1997-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
SOCS3 protein, Xenopus Chemical MeSH Browser
SOCS3 protein, human Chemical MeSH Browser
Socs3 protein, mouse Chemical MeSH Browser
Socs3 protein, rat Chemical MeSH Browser
socs3a protein, zebrafish Chemical MeSH Browser