A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.

DUI

D000071234 MeSH Prohlížeč

CUI

M0087653

Historická pozn.

2017 (1978)

Veřejná pozn.

2017; LUMICAN was indexed under KERATAN SULFATE and CHONDROITIN SULFATE PROTEOGLYCANS 1981-2016, and under KERATAN SULFATE/ANALOGS 1978-1981