Sequestosome-1 Protein [sekvestosom 1]
- Terms
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protein sekvestosom 1
sequestosom 1
vazebný protein p62
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EBI3-Associated Protein of 60 KDa
EBIAP Protein
Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
Ubiquitin-Binding Protein p62
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
- DUI
- D000071456 MeSH Browser
- CUI
- M000614776
- Previous indexing
- Adaptor Proteins, Signal Transducing (1996-2016); Heat-Shock Proteins (1996-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 2
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
SQSTM1 protein, human Chemical MeSH Browser
SQSTM1 protein, zebrafish Chemical MeSH Browser
Sqstm1 protein, mouse Chemical MeSH Browser
Sqstm1 protein, rat Chemical MeSH Browser