AlkB Enzymes [alkylační opravný homolog]
- Terms
-
alkB homolog
-
AlkB Homologs
Alkylated DNA Repair Protein AlkB Homologs
Alkylation Repair Homolog Proteins
Alkylation Repair Homologs
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
- DUI
- D000071496 MeSH Browser
- CUI
- M000614938
- Previous indexing
- Dioxygenases (2004-2016); DNA Repair Enzymes (2004-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
ALKB-8 protein, C elegans Chemical MeSH Browser
ALKBH7 protein, human Chemical MeSH Browser
ALKBH7 protein, mouse Chemical MeSH Browser
Narrower terms
- AlkB Homolog 1, Histone H2a Dioxygenase
- AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 4, Lysine Demethylase
- AlkB Homolog 5, RNA Demethylase
- AlkB Homolog 8, tRNA Methyltransferase
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO