Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases [fosfatidylinositol-3,4,5-trisfosfát-5-fosfatasy]
topical
7
- Terms
-
fosfatázy rodiny SHIP
fosfatidylinositol-3,4,5-trisfosfát 5-fosfatázy
SH2 domain-containing inositol 5-phosphatase
SHIP fosfatázy
-
SHIP Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Persistent link
https://www.medvik.cz/link/D000072183
Definition
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
- DUI
- D000072183 MeSH Browser
- CUI
- M000616490
- RN
- EC 3.1.3.86
- Previous indexing
- Phosphoric Monoester Hydrolases (1996-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 5
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 7
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D08.811.277.352.650.624
Phosphoinositide Phosphatases
D08.811.277.352.650.624.500
Inositol Polyphosphate 5-Phosphatases