Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases [fosfatidylinositol-3,4,5-trisfosfát-5-fosfatasy]
- Terms
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fosfatázy rodiny SHIP
fosfatidylinositol-3,4,5-trisfosfát 5-fosfatázy
SH2 domain-containing inositol 5-phosphatase
SHIP fosfatázy
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SHIP Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
- DUI
- D000072183 MeSH Browser
- CUI
- M000616490
- Previous indexing
- Phosphoric Monoester Hydrolases (1996-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 5
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 7
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
INPP5D protein, human Chemical MeSH Browser
INPPL1 protein, human Chemical MeSH Browser
Inpp5d protein, mouse Chemical MeSH Browser
Inppl1 protein, mouse Chemical MeSH Browser
Inppl1 protein, rat Chemical MeSH Browser
inpp5d protein, zebrafish Chemical MeSH Browser
inppl1a protein, zebrafish Chemical MeSH Browser