Dishevelled Proteins [protein dishevelled]
- Terms
-
DVL proteiny
protein DVL1
protein DVL2
protein DVL3
proteiny DVL1-3
-
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
- DUI
- D000072261 MeSH Browser
- CUI
- M0226765
- History note
- 2017 (1994)
- Public note
- 2017; DISHEVELLED PROTEINS was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2006-2016; under PHOSPHOPROTEINS 1998-2016; and under PROTEINS 1994-1997
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