NIMA-Interacting Peptidylprolyl Isomerase [peptidylprolylisomerasa Pin1]

topical
1
Terms

NIMA-interacting 1 peptidyl-prolyl cis-trans isomeráza
NIMA-interacting 1 peptidyl-prolyl cis-trans izomeráza
peptidyl-prolyl cis-trans isomeráza Pin1
peptidyl-prolyl cis-trans izomeráza Pin1
PIN1 protein

 

Peptidyl-Prolyl Cis-Trans Isomerase Pin1
Pin1 Peptidylprolyl Isomerase
PIN1 Protein

Definition

A highly-conserved peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated SERINE- or THREONINE-PROLINE (pSer/Thr-Pro) motifs and causes conformational changes in certain proteins associated with the CELL CYCLE. It displays a preference for an acidic residue N-terminal to the isomerized proline bond and regulates MITOSIS, possibly by attenuating the mitosis-promoting activity of NIMA-RELATED KINASE 1.

DUI
D000072340 MeSH Browser
CUI
M0502575
History note
2017 (1996)
Public note
2017; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE was indexed under PEPTIDYLPROLYL ISOMERASE 1997-2016; and under AMINO ACID ISOMERASES 1996-1997