Cytokine TWEAK [cytokin TWEAK]
- Terms
-
slabý induktor apoptózy skupiny tumor nekrotizujícího faktoru
slabý induktor apoptózy TNF
TNF příbuzný slabý induktor apoptózy
TWEAK
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Apo3 Ligand
TNF-Related Weak Inducer of Apoptosis
Tumor Necrosis Factor Ligand Superfamily Member 12
TWEAK Cytokine
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
- DUI
- D000074049 MeSH Browser
- CUI
- M000625319
- Previous indexing
- Tumor Necrosis Factors (2006-2017)
- History note
- 2018
- Public note
- 2018
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