Mechanistic Target of Rapamycin Complex 1 [mTORC1]

topical
18
Terms

komplex mTORC1
mechanistický cíl rapamycinu, komplex 1
TORC1

 

mTORC1
mTORC1 Complex
Target of Rapamycin Complex 1
TOR Complex 1
TORC1

Persistent link   https://www.medvik.cz/link/D000076222
Definition

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

DUI
D000076222 MeSH Browser
CUI
M0579317
History note
2018 (2013)
Public note
2018; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 3
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 10
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.049 Amyloid 166
D05.500.099 Apoptosomes 2
D05.500.117 Axin Signaling Complex 1
D05.500.135 Calcifying Nanoparticles 1
D05.500.139 COP9 Signalosome Complex
D05.500.142 Dynactin Complex 1
D05.500.149 Dystrophin-Associated Protein Complex 1
D05.500.199 Endosomal Sorting Complexes Required for Transport 8
D05.500.224 Inflammasomes 27
D05.500.299 Lactose Synthase
D05.500.337 Mechanistic Target of Rapamycin Complex 1 18
D05.500.337.250 mTOR Associated Protein, LST8 Homolog
D05.500.337.500 Regulatory-Associated Protein of mTOR
D05.500.356 Mechanistic Target of Rapamycin Complex 2 3
D05.500.374 Mediator Complex 5
D05.500.437 Mitochondrial Permeability Transition Pore 8
D05.500.469 Mitochondrial Precursor Protein Import Complex Proteins
D05.500.500 Molecular Motor Proteins 11
D05.500.562 Multienzyme Complexes 40
D05.500.672 NF-kappa B 220
D05.500.781 Polycomb-Group Proteins 7
D05.500.890 Protein Translocation Systems
D05.500.918 Shelterin Complex 2
D05.500.945 Troponin 266
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 549
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 249
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 273
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 196
D08.811.913.696.620.682.700.931.500 Mechanistic Target of Rapamycin Complex 1 18
D08.811.913.696.620.682.700.931.500.250 mTOR Associated Protein, LST8 Homolog
D08.811.913.696.620.682.700.931.500.500 Regulatory-Associated Protein of mTOR
D08.811.913.696.620.682.700.931.750 Mechanistic Target of Rapamycin Complex 2 3
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 579
D12.776.476 Intracellular Signaling Peptides and Proteins 175
D12.776.476.563 Protein Serine-Threonine Kinases 273
D12.776.476.563.931 TOR Serine-Threonine Kinases 196
D12.776.476.563.931.500 Mechanistic Target of Rapamycin Complex 1 18
D12.776.476.563.931.500.250 mTOR Associated Protein, LST8 Homolog
D12.776.476.563.931.500.500 Regulatory-Associated Protein of mTOR
D12.776.476.563.931.750 Mechanistic Target of Rapamycin Complex 2 3

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