Mechanistic Target of Rapamycin Complex 2 [mTORC2]

topical
3
Terms

mechanistický cíl rapamycinu, komplex 2
mTORC-2
TORC2

 

MTORC-2
mTORC2
Target of Rapamycin Complex 2
TOR Complex 2
TORC2

Persistent link   https://www.medvik.cz/link/D000076225
Definition

A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.

DUI
D000076225 MeSH Browser
CUI
M0579319
History note
2018 (2013)
Public note
2018; see TOR COMPLEX 2 2013-2017; MECHANISTIC TARGET OF RAPAMYCIN 2 COMPLEX was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects 1
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 2
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.049 Amyloid 166
D05.500.099 Apoptosomes 2
D05.500.117 Axin Signaling Complex 1
D05.500.135 Calcifying Nanoparticles 1
D05.500.139 COP9 Signalosome Complex
D05.500.142 Dynactin Complex 1
D05.500.149 Dystrophin-Associated Protein Complex 1
D05.500.199 Endosomal Sorting Complexes Required for Transport 8
D05.500.224 Inflammasomes 25
D05.500.299 Lactose Synthase
D05.500.337 Mechanistic Target of Rapamycin Complex 1 18
D05.500.356 Mechanistic Target of Rapamycin Complex 2 3
D05.500.356.500 Rapamycin-Insensitive Companion of mTOR Protein 2
D05.500.374 Mediator Complex 5
D05.500.437 Mitochondrial Permeability Transition Pore 8
D05.500.469 Mitochondrial Precursor Protein Import Complex Proteins
D05.500.500 Molecular Motor Proteins 11
D05.500.562 Multienzyme Complexes 40
D05.500.672 NF-kappa B 218
D05.500.781 Polycomb-Group Proteins 7
D05.500.890 Protein Translocation Systems
D05.500.918 Shelterin Complex 2
D05.500.945 Troponin 264
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 271
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 193
D08.811.913.696.620.682.700.931.500 Mechanistic Target of Rapamycin Complex 1 18
D08.811.913.696.620.682.700.931.750 Mechanistic Target of Rapamycin Complex 2 3
D08.811.913.696.620.682.700.931.750.500 Rapamycin-Insensitive Companion of mTOR Protein 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.563 Protein Serine-Threonine Kinases 271
D12.776.476.563.931 TOR Serine-Threonine Kinases 193
D12.776.476.563.931.500 Mechanistic Target of Rapamycin Complex 1 18
D12.776.476.563.931.750 Mechanistic Target of Rapamycin Complex 2 3
D12.776.476.563.931.750.500 Rapamycin-Insensitive Companion of mTOR Protein 2

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