mTOR Associated Protein, LST8 Homolog [protein mLST8]

topical
Terms

protein GBetaL

 

G protein beta Subunit-like Polypeptide
GBetaL Protein
mLST8 Protein

Persistent link   https://www.medvik.cz/link/D000076242
Definition

An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.

DUI
D000076242 MeSH Browser
CUI
M000632423
Previous indexing
Proteins (2011-2017); Adaptor Proteins, Signal Transducing (2013-2017)
History note
2018
Public note
2018

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.337 Mechanistic Target of Rapamycin Complex 1 18
D05.500.337.250 mTOR Associated Protein, LST8 Homolog
D05.500.337.500 Regulatory-Associated Protein of mTOR
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 271
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 193
D08.811.913.696.620.682.700.931.500 Mechanistic Target of Rapamycin Complex 1 18
D08.811.913.696.620.682.700.931.500.250 mTOR Associated Protein, LST8 Homolog
D08.811.913.696.620.682.700.931.500.500 Regulatory-Associated Protein of mTOR
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 380
D12.644.360 Intracellular Signaling Peptides and Proteins 174
D12.644.360.024 Adaptor Proteins, Signal Transducing 176
D12.644.360.024.050 14-3-3 Proteins 75
D12.644.360.024.065 A Kinase Anchor Proteins 1
D12.644.360.024.082 Angiomotins 1
D12.644.360.024.098 Arrestins 6
D12.644.360.024.131 CARD Signaling Adaptor Proteins 7
D12.644.360.024.264 Caveolin 1 14
D12.644.360.024.272 Caveolin 2 1
D12.644.360.024.280 Cortactin 1
D12.644.360.024.282 Crk-Associated Substrate Protein 7
D12.644.360.024.285 Death Domain Receptor Signaling Adaptor Proteins 5
D12.644.360.024.287 Discs Large Homolog 1 Protein
D12.644.360.024.288 Dishevelled Proteins 18
D12.644.360.024.290 GRB2 Adaptor Protein 3
D12.644.360.024.299 GRB7 Adaptor Protein
D12.644.360.024.300 GRB10 Adaptor Protein
D12.644.360.024.301 Insulin Receptor Substrate Proteins 6
D12.644.360.024.302 Interferon Regulatory Factors 11
D12.644.360.024.303 Interferon-Stimulated Gene Factor 3
D12.644.360.024.306 Kelch-Like ECH-Associated Protein 1 9
D12.644.360.024.309 Mediator Complex 5
D12.644.360.024.310 mTOR Associated Protein, LST8 Homolog
D12.644.360.024.311 Myeloid Differentiation Factor 88 16
D12.644.360.024.313 Nod Signaling Adaptor Proteins 1
D12.644.360.024.314 Nuclear Receptor Coactivators 6
D12.644.360.024.315 Nuclear Receptor Interacting Protein 1 3
D12.644.360.024.316 Paxillin 5
D12.644.360.024.318 PII Nitrogen Regulatory Proteins
D12.644.360.024.319 Protein Inhibitors of Activated STAT 3
D12.644.360.024.320 Proto-Oncogene Proteins c-crk 1
D12.644.360.024.321 Proto-Oncogene Proteins c-vav 4
D12.644.360.024.322 Rabphilin-3A
D12.644.360.024.323 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.644.360.024.324 Regulatory-Associated Protein of mTOR
D12.644.360.024.328 Retinoblastoma Binding Proteins 3
D12.644.360.024.329 Sequestosome-1 Protein 3
D12.644.360.024.330 Shc Signaling Adaptor Proteins
D12.644.360.024.332 Signaling Lymphocytic Activation Molecule Associated Protein
D12.644.360.024.334 Smad Proteins 14
D12.644.360.024.342 STAT Transcription Factors 23
D12.644.360.024.374 Suppressor of Cytokine Signaling Proteins 11
D12.644.360.024.437 Syntenins 2
D12.644.360.024.469 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.644.360.024.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.644.360.024.750 YAP-Signaling Proteins 5
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.057 Adaptor Proteins, Signal Transducing 176
D12.776.157.057.001 5-Lipoxygenase-Activating Proteins 1
D12.776.157.057.002 14-3-3 Proteins 75
D12.776.157.057.003 A Kinase Anchor Proteins 1
D12.776.157.057.005 Arrestins 6
D12.776.157.057.006 CARD Signaling Adaptor Proteins 7
D12.776.157.057.010 Caveolin 1 14
D12.776.157.057.012 Caveolin 2 1
D12.776.157.057.014 Cortactin 1
D12.776.157.057.016 Crk-Associated Substrate Protein 7
D12.776.157.057.018 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.157.057.023 Discs Large Homolog 1 Protein
D12.776.157.057.028 Dishevelled Proteins 18
D12.776.157.057.039 GRB10 Adaptor Protein
D12.776.157.057.041 GRB2 Adaptor Protein 3
D12.776.157.057.043 GRB7 Adaptor Protein
D12.776.157.057.045 Insulin Receptor Substrate Proteins 6
D12.776.157.057.050 Interferon Regulatory Factors 11
D12.776.157.057.061 Interferon-Stimulated Gene Factor 3
D12.776.157.057.067 Kelch-Like ECH-Associated Protein 1 9
D12.776.157.057.072 Mediator Complex 5
D12.776.157.057.073 mTOR Associated Protein, LST8 Homolog
D12.776.157.057.074 Myeloid Differentiation Factor 88 16
D12.776.157.057.078 Nod Signaling Adaptor Proteins 1
D12.776.157.057.080 Nuclear Receptor Coactivators 6
D12.776.157.057.086 Nuclear Receptor Interacting Protein 1 3
D12.776.157.057.092 Paxillin 5
D12.776.157.057.110 PII Nitrogen Regulatory Proteins
D12.776.157.057.124 Protein Inhibitors of Activated STAT 3
D12.776.157.057.139 Proto-Oncogene Proteins c-crk 1
D12.776.157.057.144 Proto-Oncogene Proteins c-vav 4
D12.776.157.057.150 Rabphilin-3A
D12.776.157.057.155 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.776.157.057.157 Regulatory-Associated Protein of mTOR
D12.776.157.057.158 Retinoblastoma Binding Proteins 3
D12.776.157.057.160 Sequestosome-1 Protein 3
D12.776.157.057.162 Shc Signaling Adaptor Proteins
D12.776.157.057.166 Signaling Lymphocytic Activation Molecule Associated Protein
D12.776.157.057.170 Smad Proteins 14
D12.776.157.057.186 STAT Transcription Factors 23
D12.776.157.057.249 Suppressor of Cytokine Signaling Proteins 11
D12.776.157.057.374 Syntenins 2
D12.776.157.057.437 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.776.157.057.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.776.157.057.750 YAP-Signaling Proteins 5
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.024 Adaptor Proteins, Signal Transducing 176
D12.776.476.024.034 5-Lipoxygenase-Activating Proteins 1
D12.776.476.024.050 14-3-3 Proteins 75
D12.776.476.024.069 A Kinase Anchor Proteins 1
D12.776.476.024.087 Angiomotins 1
D12.776.476.024.104 Arrestins 6
D12.776.476.024.139 CARD Signaling Adaptor Proteins 7
D12.776.476.024.280 Caveolin 1 14
D12.776.476.024.295 Caveolin 2 1
D12.776.476.024.311 Cortactin 1
D12.776.476.024.316 Crk-Associated Substrate Protein 7
D12.776.476.024.320 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.024.325 Discs Large Homolog 1 Protein
D12.776.476.024.330 Dishevelled Proteins 18
D12.776.476.024.377 GRB2 Adaptor Protein 3
D12.776.476.024.379 GRB7 Adaptor Protein
D12.776.476.024.380 GRB10 Adaptor Protein
D12.776.476.024.381 Homer Scaffolding Proteins 1
D12.776.476.024.382 Insulin Receptor Substrate Proteins 6
D12.776.476.024.385 Interferon Regulatory Factors 11
D12.776.476.024.386 Interferon-Stimulated Gene Factor 3
D12.776.476.024.387 Kelch-Like ECH-Associated Protein 1 9
D12.776.476.024.388 Mediator Complex 5
D12.776.476.024.389 mTOR Associated Protein, LST8 Homolog
D12.776.476.024.390 Myeloid Differentiation Factor 88 16
D12.776.476.024.391 Nod Signaling Adaptor Proteins 1
D12.776.476.024.394 Nuclear Receptor Coactivators 6
D12.776.476.024.396 Nuclear Receptor Interacting Protein 1 3
D12.776.476.024.397 Paxillin 5
D12.776.476.024.400 PII Nitrogen Regulatory Proteins
D12.776.476.024.402 Protein Inhibitors of Activated STAT 3
D12.776.476.024.404 Proto-Oncogene Proteins c-crk 1
D12.776.476.024.407 Proto-Oncogene Proteins c-vav 4
D12.776.476.024.409 Rabphilin-3A
D12.776.476.024.411 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.776.476.024.414 Receptor Activity-Modifying Proteins 1
D12.776.476.024.419 Regulatory-Associated Protein of mTOR
D12.776.476.024.420 Retinoblastoma Binding Proteins 3
D12.776.476.024.422 Sequestosome-1 Protein 3
D12.776.476.024.424 Shc Signaling Adaptor Proteins
D12.776.476.024.426 Signaling Lymphocytic Activation Molecule Associated Protein
D12.776.476.024.428 Smad Proteins 14
D12.776.476.024.430 STAT Transcription Factors 23
D12.776.476.024.437 Suppressor of Cytokine Signaling Proteins 11
D12.776.476.024.468 Syntenins 2
D12.776.476.024.484 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.776.476.024.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.776.476.024.750 YAP-Signaling Proteins 5
D12.776.476.563 Protein Serine-Threonine Kinases 271
D12.776.476.563.931 TOR Serine-Threonine Kinases 193
D12.776.476.563.931.500 Mechanistic Target of Rapamycin Complex 1 18
D12.776.476.563.931.500.250 mTOR Associated Protein, LST8 Homolog
D12.776.476.563.931.500.500 Regulatory-Associated Protein of mTOR

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