Mitochondrial Permeability Transition Pore [přechodový pór mitochondriální permeability]

topical
8
Terms

mitochondriální megakanál
mitochondriální pór přechodné propustnosti
mPTP

 

Mitochondrial Megachannel
Mitochondrial Permeability Transition Pore (mPTP)
mPTP Protein

Persistent link   https://www.medvik.cz/link/D000083162
Definition

A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.

DUI
D000083162 MeSH Browser
CUI
M000678777
History note
2021(1999)
Public note
Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors 1
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 6
PK
pharmacokinetics
PD
pharmacology 1
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine

D Chemicals and Drugs
D05 Macromolecular Substances 103
D05.500 Multiprotein Complexes 65
D05.500.049 Amyloid 166
D05.500.099 Apoptosomes 2
D05.500.117 Axin Signaling Complex 1
D05.500.135 Calcifying Nanoparticles 1
D05.500.139 COP9 Signalosome Complex
D05.500.142 Dynactin Complex 1
D05.500.149 Dystrophin-Associated Protein Complex 1
D05.500.199 Endosomal Sorting Complexes Required for Transport 8
D05.500.224 Inflammasomes 27
D05.500.299 Lactose Synthase
D05.500.337 Mechanistic Target of Rapamycin Complex 1 18
D05.500.356 Mechanistic Target of Rapamycin Complex 2 3
D05.500.374 Mediator Complex 5
D05.500.437 Mitochondrial Permeability Transition Pore 8
D05.500.469 Mitochondrial Precursor Protein Import Complex Proteins
D05.500.500 Molecular Motor Proteins 11
D05.500.562 Multienzyme Complexes 40
D05.500.672 NF-kappa B 220
D05.500.781 Polycomb-Group Proteins 7
D05.500.890 Protein Translocation Systems
D05.500.918 Shelterin Complex 2
D05.500.945 Troponin 266
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.543 Membrane Proteins 850
D12.776.543.585 Membrane Transport Proteins 207
D12.776.543.585.475 Mitochondrial Membrane Transport Proteins 35
D12.776.543.585.475.500 Mitochondrial ADP, ATP Translocases 26
D12.776.543.585.475.563 Mitochondrial Permeability Transition Pore 8
D12.776.543.585.475.594 Mitochondrial Precursor Protein Import Complex Proteins
D12.776.543.585.475.625 Mitochondrial Proton-Translocating ATPases 47
D12.776.543.585.475.688 Mitochondrial Uncoupling Proteins 2
D12.776.543.585.475.719 Solute Carrier Family 44, Member 2 Protein
D12.776.543.585.475.735 Steroidogenic Acute Regulatory Protein
D12.776.543.585.475.750 Voltage-Dependent Anion Channel 1 2
D12.776.543.585.475.875 Voltage-Dependent Anion Channel 2 1
D12.776.575 Mitochondrial Proteins 209
D12.776.575.750 Mitochondrial Membrane Transport Proteins 35
D12.776.575.750.500 Mitochondrial ADP, ATP Translocases 26
D12.776.575.750.563 Mitochondrial Permeability Transition Pore 8
D12.776.575.750.594 Mitochondrial Precursor Protein Import Complex Proteins
D12.776.575.750.625 Mitochondrial Proton-Translocating ATPases 47
D12.776.575.750.688 Mitochondrial Uncoupling Proteins 2
D12.776.575.750.719 Solute Carrier Family 44, Member 2 Protein
D12.776.575.750.735 Steroidogenic Acute Regulatory Protein
D12.776.575.750.750 Voltage-Dependent Anion Channel 1 2
D12.776.575.750.875 Voltage-Dependent Anion Channel 2 1

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